... with a large size and show a short G1 and a long G2. However, when cultured in nitrogen-poor media, they exhibit reduced growth rate and cell size and a long G1 and a short G2. In this study, we compared the phenotypes of cells lacking the highly conserved cyclin-dependent kinase (Cdk) inhibitor Rum1...

...Alberto Sánchez-Díaz; Isabel González; Manuel Arellano; Sergio Moreno ABSTRACT p25 rum1 and p40 SIC1 are specific inhibitors of p34 cdc2/CDC28 kinase complexes with B-type cyclins that play a central role in the regulation of the G 1 phase of the cell cycle. We show here that low levels...

...Karim Labib; Sergio Moreno; Paul Nurse ABSTRACT The p34 cdc2 kinase is essential for progression past Start in the G 1 phase of the fission yeast cell cycle, and also acts in G 2 to promote mitotic entry. Whilst very little is known about the G 1 function of cdc2 , the rum1 gene has recently been...