... known as CDK5RAP2), and vice versa, and these proteins are independently recruited to the centrosome. Rather, Cep44 associates with rootletin and regulates its stability and localization to the centrosome. Our findings reveal a role of the previously uncharacterized protein Cep44 for centrosome cohesion...

... with the centrosome linker components rootletin and LRRC45. CCDC102B decorates and facilitates the formation of rootletin filaments. Furthermore, CCDC102B is phosphorylated by Nek2A (an isoform encoded by NEK2 ) and is disassociated from the centrosome at the onset of mitosis. Together, our findings reveal...

... ‡ Authors for correspondence ( bixl@dlmedu.edu.cn ; yuanli@ucas.ac.cn ) Competing interests The authors declare no competing interests. 31 07 2013 31 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Centrosome cohesion Centlein Cep68 C-Nap1 Rootletin...

... proposes that parental centrioles are held together through centriole-associated, entangling filaments. Central to this model are C-Nap1, a putative centriolar docking protein and rootletin, a fibrous component. Here we identify two novel proteins, Cep68 and Cep215, as required for centrosome cohesion...