... Phosphodiesterase-4 PDE4 LIS1 Rolipram PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit α (PAFAH1B1 also known and, hereafter, referred to as LIS1) has an N-terminal coiled–coiled domain for self-association ( Ahn and Morris, 2001 ) and a C-terminal β-propeller structure formed from seven...

..., such as forskolin and IBMX. In particular, by using the specific inhibitor rolipram, we identify the PDE4 family of cAMP-specific phosphodiesterases as critical regulators of this process. The effect of PDE4 on microspike formation is mediated by actions exerted through the activation of PKA – rather than through...