... a major role in the initial transcriptional response to extracellular matrix stiffness and mediates the stiffness-dependent repression of ATF3, resulting in the induction of cyclin D1. ECM RNAseq Cell cycling Mechanotransduction Proliferation Rigidity National Institutes of Health...

... and cancer cells drives chromosome losses, which myosin-II suppression maximizes. Confinement Compression Myosin Rigidity Aneuploidy Heritability National Institutes of Health http://dx.doi.org/10.13039/100000002 National Cancer Institute http://dx.doi.org/10.13039/100000054...

... and opposite reactive force arises in the ECM (which can be thought of as a passive spring). Studies demonstrate that when the ECM is not rigid – for example, when cells attach to small, submicrometer-diameter beads coated with ECM ligands – cytoskeletal tension and stress at adhesions do not develop and focal...

... were kindly provided by T. Svitkina (Northwestern University) and were cultured in HAM's F-10 medium supplemented with 10% fetal bovine serum (GIBCO). Okadaic acid and calyculin A were from Sigma. Microtubule Tau Axon Tubulin Photobleaching Rigidity © The Company of Biologists Limited...