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Keywords: Rhodopsin
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (10): jcs229526.
Published: 15 May 2019
...Abhishek Chadha; Stefanie Volland; Natella V. Baliaouri; Elaine M. Tran; David S. Williams ABSTRACT The photoreceptor outer segment is the most elaborate primary cilium, containing large amounts of rhodopsin (RHO) in disk membranes that grow from a connecting cilium. The movement of RHO along...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (24): jcs222034.
Published: 10 December 2018
...Vasundhara Kandachar; Beatrice M. Tam; Orson L. Moritz; Dusanka Deretic ABSTRACT The Arf4–rhodopsin complex (mediated by the VxPx motif in rhodopsin) initiates expansion of vertebrate rod photoreceptor cilia-derived light-sensing organelles through stepwise assembly of a conserved trafficking...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (23): 3975–3987.
Published: 01 December 2017
... receptor, rhodopsin. Rhodopsin and Arf4 bind the regulatory N-terminal dimerization and cyclophillin-binding (DCB)-homology upstream of Sec7 (HUS) domain of GBF1. The complex is sensitive to Golgicide A (GCA), a selective inhibitor of GBF1 that accordingly blocks rhodopsin delivery to the cilia, without...
Journal Articles
J Cell Sci (2016) 129 (2): 394–405.
Published: 15 January 2016
...Ying Xu; Tao Wang ABSTRACT Endocytosis of G-protein-coupled receptors (GPCRs) and associated channels contributes to desensitization and adaptation of a variety of signaling cascades. In Drosophila melanogaster , the main light-sensing rhodopsin (Rh1; encoded by ninaE ) and the downstream ion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1375–1385.
Published: 01 April 2015
... cilia are still unknown. Here, we show that the Arf and Rab11 effector FIP3 (also known as RAB11FIP3) promotes the activity of Rab11a and the Arf GTPase-activating protein (GAP) ASAP1 in the Arf4-dependent ciliary transport of the sensory receptor rhodopsin. During its passage out of the photoreceptor...
Journal Articles
J Cell Sci (2014) 127 (17): 3852–3861.
Published: 01 September 2014
...) phagocytosis by the RPE provides a unique opportunity to analyse phagosome processing in vivo . In mouse retinae, phagosomes containing stacked rhodopsin-rich discs were identified by immuno-electron microscopy. Early apical phagosomes stained with antibodies against both cytoplasmic and intradiscal domains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1247–1259.
Published: 01 March 2013
... in the Ca 2+ -dependent visual pigment cycle, which result in accumulation of toxic phosphorylated metarhodopsin–arrestin complexes (M PP –Arr2). Here we show that two interventions, which prevent accumulation of M PP –Arr2, namely rearing under red light or eliminating the C-terminal rhodopsin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4465–4472.
Published: 15 December 2009
... target in rhodopsin RP and other protein-misfolding diseases. EDEM1 (ER degradation-enhancing, α-mannosidase-like 1) enhances ERAD of a terminally misfolded α1-antitrypsin variant, null Hong Kong (NHK, HK A1AT) ( Hosokawa et al., 2001 ). The overexpression of recombinant EDEM1 can enhance the release...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2003–2013.
Published: 15 June 2009
...Jana Mazelova; Nancy Ransom; Lisa Astuto-Gribble; Michael C. Wilson; Dusanka Deretic The biogenesis of cilia-derived sensory organelles, the photoreceptor rod outer segments (ROS), is mediated by rhodopsin transport carriers (RTCs). The small GTPase Rab8 regulates ciliary targeting of RTCs...
Journal Articles
J Cell Sci (2006) 119 (15): 3141–3148.
Published: 01 August 2006
...Nicholas R. Orem; Luxi Xia; Patrick J. Dolph Previously, we have identified a class of retinal degeneration mutants in Drosophila in which the normally transient interaction between arrestin2 (Arr2) and rhodopsin is stabilized and the complexes are rapidly internalized into the cell body...
Journal Articles
J Cell Sci (2002) 115 (14): 2907–2918.
Published: 15 July 2002
...Richard S. Saliba; Peter M. G. Munro; Philip J. Luthert; Michael E. Cheetham Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein. Through the detailed examination of P23H...