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Keywords: RhoGEF
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Journal Articles
J Cell Sci (2016) 129 (19): 3620–3634.
Published: 1 October 2016
... form of RhoA ( Fig. S4A,B ). Although the residual GEF activity of mouse ARHGEF10 L548A might be sufficient to rescue Rab8 impairment induced by ARHGEF10 knockdown, our results strongly suggest that ARHGEF10 does not behave as a RhoGEF in the membrane transport pathway. Alternatively, ARHGEF10 might...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 1963–1974.
Published: 15 May 2016
... unclear which partners bind simultaneously and may be able to function together. Furthermore, the tight linkage of an ArfGAP and RhoGEF suggests a coordination of GAP and GEF functions. In GIT–PIX-dependent systems, elevated Rac1 and/or Cdc42 activity has been found to be associated with reduced Arf6...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1692–1702.
Published: 1 April 2013
..., triggers radial polarization by inactivating CDC-42 at these sites. The mechanisms responsible for activating CDC-42 at contact-free surfaces are unknown. Here, in an overexpression screen of Rho guanine nucleotide exchange factors (RhoGEFs), which can activate Rho GTPases, we identify CGEF-1 and ECT-2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (16): 2786–2796.
Published: 15 August 2011
... which of them is capable of activating Cdc42 in vivo. By drawing an analogy with other RhoGEFs ( Murayama et al., 2007 ), we speculate that the CB SH3 domain inhibits the DH domain catalytic activity, thereby providing an explanation for why CB2 SH3− can mediate translocation of gephyrin to the plasma...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2601–2611.
Published: 1 August 2008
... Kalirin function throughout development. * Author for correspondence (e-mail: eipper@uchc.edu ) 16 6 2008 © The Company of Biologists Limited 2008 2008 RhoGEF PC12 cells Spectrin-like repeats PP-1 Phosphorylation Roscovitine Calyculin A We thank Martin Schiller...
Journal Articles
J Cell Sci (2008) 121 (10): 1739–1749.
Published: 15 May 2008
... exchange factor (RhoGEF). BNIPXL does not recognize the constitutive active G14V and Q63L mutants of RhoA but targets the fast-cycling F30L and the dominant-negative T19N mutants. A second region at the N-terminus of BNIPXL also targets the proline-rich region of Lbc. Whereas overexpression of BNIPXL...
Includes: Supplementary data