... and the MST3 and MST4 protein kinases. Rho-GTPases Golgi orientation FAM65A CCM3 MST4 Cerebral cavernous malformation Establishment of front–back polarity is crucial for directional migration of mesenchymal-like cells ( Etienne-Manneville, 2008 ). In addition to the asymmetric organisation...

... actin, the stability of the apical junctional complex and polarization of epithelial cells. Rho–GTPases Actin Cell–cell adhesion Kinesin We showed previously that KIF17 localizes to microtubule plus-ends with EB1 (also known as MAPRE1) and contributes to microtubule stabilization...

... for correspondence ( marios.georgiou@ucl.ac.uk ) 12 1 2010 © 2010. 2010 Par Polarity Epithelia Rho-GTPases Protrusions Actin Animal cells are able to form a number of distinct dynamic actin-filament-based structures. These include microvilli, filopodia and lamellipodia, each of which...

...@hsr.it ) 3 3 2009 © The Company of Biologists Limited 2009 2009 EFA6A ARF6 GEF Cytoskeletal remodeling Neurons Neurite extension Dendrite branching Rho-GTPases The regulation of GTPases forms the basis of a wide variety of cellular processes, such as differentiation...

... of the FAK-Src complex also stimulates membrane protrusion and inhibits cytoskeletal contractility, thereby facilitating cell spreading. Fig. 2. Overview of Rho-GTPases, the GAPs and GEFs that regulate them and the effector pathways that act downstream of integrins. An overview of the currently...