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Keywords: Rho kinase
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Journal Articles
J Cell Sci (2021) 134 (1): jcs248732.
Published: 13 January 2021
... in normal breast cells and breast cancer cells depends on non-muscle myosin II activity, which is fine tuned by ROCK and MLCK. Blebbing Lamellipodia Membrane protrusive activity Non-muscle myosin II Rho kinase Myosin regulatory light chain kinase Council of Scientific and Industrial...
Journal Articles
J Cell Sci (2015) 128 (7): 1316–1326.
Published: 1 April 2015
..., cells using αvβ3 respond to lower stiffness ranges, reorganize their actin cytoskeleton more substantially in response to stretch, and show more randomly oriented traction forces. Centripetal traction force orientation requires long stress fibers that are formed through the action of Rho kinase (ROCK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1077–1087.
Published: 1 April 2011
... motility in C33A/CA9 cells. These invasive and metastatic phenotypes were associated with Rho-GTPase-related epithelial-mesenchymal transition. Inhibition of the Rho/Rho kinase pathway by a ROCK inhibitor (Y27632) and si-Rho (short interference RNA against RhoA) showed that Rho-GTPase signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1751–1760.
Published: 15 May 2010
... . The joint action of both contraction modes can result in macroscopic tissue contractures of ~1 cm per month. * Author for correspondence ( [email protected] ) 5 3 2010 © 2010. 2010 Myofibroblast Fibrosis Calcium oscillations Rho kinase Stress fibre Collagen...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (16): 2696–2704.
Published: 15 August 2008
... receptors that regulate fibronectin assembly and disruption of Rho kinase all result in suppressed deposition of both fibronectin and microfibrils. Antibody activation of β1 integrins in fibronectin-depleted cultures is insufficient to rescue microfibril assembly. In fibronectin RGE/RGE mutant mouse...
Includes: Supplementary data
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Lipid biology
J Cell Sci (2005) 118 (10): 2211–2223.
Published: 15 May 2005
... cellular polarization, as visualized by the orchestrated reorganization of CD95, F-actin and lipid rafts, was shown to be dependent on signaling by Rho kinase (ROCK) in both cell types, however, by distinct activation mechanisms in the respective cell type. CD95 activated RhoA exclusively in the type II...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (17): 3491–3501.
Published: 1 September 2003
... that the pathway of Rho kinase (ROCK)/myosin light chain (MLC)phosphorylation/myosin-mediated contraction was activated in PMA-induced apoptotic cells in serum-containing medium, but not in the adherent and survived cells. Pretreatment of cells with a specific ROCK inhibitor, Y27632,not only abrogated MLC...
Journal Articles
J Cell Sci (2003) 116 (15): 3123–3133.
Published: 1 August 2003
... changes in the acto-myosin cytoskeleton under the regulation of myosin light chain kinase and ROCK (Rho kinase). A key finding is that the activity of these two kinases is spatially segregated. Myosin light chain kinase (MLCK)must operate at the leading edge of the T cell because blocking its activity...
Includes: Multimedia, Supplementary data