...Cheng-Gee Koh; Ed Manser; Zhou-Shen Zhao; Chee-Peng Ng; Louis Lim PIX is a Rho-family guanine nucleotide exchange factor that binds PAK. We previously described two isoforms of PIX that differ in their N termini. Here, we report the identification of a new splice variant of βPIX, designated β2PIX...

... of responses to the environment, including remodeling and assembly of the actin cytoskeleton. Although it has been clear for some time that Rho family GTPases play a central role in the orchestration of cytoskeletal assembly, our understanding of the components that regulate these important molecules is far...

... al., 1992 ), and RhoG, a GTPase 72% identical to Rac1 and 62% to Cdc42Hs, activates independently Rac1 and Cdc42Hs ( Gauthier-Rouvière et al., 1998 ). GEF GTPase Rho family RhoG Trio Fibroblast REFERENCES Aronheim , A. , Broder , Y. C. , Cohen , A. , Fritsch...

...Phillip Lamoureux; Zeynep F. Altun-Gultekin; Chingju Lin; John A. Wagner; Steven R. Heidemann ABSTRACT Recent work has suggested that racl and other members of the rho family of small GTP-binding proteins play an important role in the formation of neural processes. We have explored the mechanism...