... the importance of the RhoGAP function of DLC1 during its role as an effector of YAP in sprouting angiogenesis. Because Rho GTPases control cytoskeletal and adhesion-mediated cellular remodeling, which are key upstream determinants of YAP/TAZ ( Totaro et al., 2018 ), we hypothesized that DLC1-driven...

...Eike K. Mahlandt; Gabriel Kreider-Letterman; Anna O. Chertkova; Rafael Garcia-Mata; Joachim Goedhart ABSTRACT Rac (herein referring to the Rac family) and Cdc42 are Rho GTPases that regulate the formation of lamellipoda and filopodia, and are therefore crucial in processes such as cell migration...

...Georgina P. Coló; Andrea Seiwert; Raquel B. Haga ABSTRACT Fibronectin (FN)-binding integrins control a variety of cellular responses through Rho GTPases. The FN-binding integrins, αvβ3 and α5β1, are known to induce different effects on cell morphology and motility. Here, we report that FN-bound...

... by regulating signaling molecules as well as CP, and that the continuous cycling of the nucleotide state of Rho GTPases is often required to drive Rho-dependent biological processes. References Barfod , E. T. , Zheng , Y. , Kuang , W. J. , Hart , M. J. , Evans , T. , Cerione , R...

...Eike K. Mahlandt; Janine J. G. Arts; Werner J. van der Meer; Franka H. van der Linden; Simon Tol; Jaap D. van Buul; Theodorus W. J. Gadella; Joachim Goedhart ABSTRACT Rho GTPases are regulatory proteins, which orchestrate cell features such as morphology, polarity and movement. Therefore, probing...

.... Rho GTPase Signal transduction Trio family Cytoskeleton Neurodevelopmental disorders Cell morphogenesis Trio family proteins are key regulators of cell motility and morphogenesis, tissue development, and protein trafficking and secretion in numerous biological contexts, including...

... opportunities for the treatments against osteoporosis, as reviewed here. Intermediate filament Microtubule Osteoclast Osteoporosis Rho GTPase Septin Centre National de la Recherche Scientifique 10.13039/501100004794 Montpellier University Fondation pour la Recherche...

...Yanyang Bai; Daji Guo; Xiaoyu Sun; Genyun Tang; Tailin Liao; Yinghui Peng; Junyu Xu; Lei Shi ABSTRACT Rac1, an important Rho GTPase that regulates the actin cytoskeleton, has long been suggested to participate in acetylcholine receptor (AChR) clustering at the postsynaptic neuromuscular junction...

...Claire Marceaux; Dominique Petit; Jacques Bertoglio; Muriel D. David ABSTRACT ARHGAP19 is a hematopoietic-specific Rho GTPase-activating protein (RhoGAP) that acts through the RhoA/ROCK pathway to critically regulate cell elongation and cytokinesis during lymphocyte mitosis. We report here...

... receptor β PDGFRβ Platelet-derived growth factor BB PDGF-BB Endocytosis Signal transducer and activator of transcription 3 STAT3 Rho GTPase Fundacja na rzecz Nauki Polskiej 10.13039/501100001870 European Regional Development Fund 10.13039/501100008530 Narodowe...

...-licence-1-1/ Summary: We discuss microtubule functions that control cell shape and motility in 3D matrices, and the differences of microtubule involvement in cell morphogenesis and motility between 2D and 3D environments. +TIP 3D matrix Rho GTPase Cancer Cell migration Microtubule...

...Brad McColl; Ritu Garg; Philippe Riou; Kirsi Riento; Anne J. Ridley ABSTRACT Rnd proteins are atypical members of the Rho GTPase family that induce actin cytoskeletal reorganization and cell rounding. Rnd proteins have been reported to bind to the intracellular domain of several plexin receptors...

.... * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing interests. © 2014. Published by The Company of Biologists Ltd 2014 Rho GTPase Infection Polarity Tight junction Epithelia form functional barriers...

... (GEFs), GTPase-activating proteins (GAPs), and guanine-nucleotide-dissociation inhibitors (GDIs). In this Commentary, we focus on current understanding on how polarity complexes interact with GEFs and GAPs to control the precise location and activation of Rho GTPases (Crumbs for RhoA, Par for Rac1...

... availability to control Rho GTPase activity. Cells were collected from culture dishes using a rubber policeman on ice and pelleted at 1000 rpm for 5 minutes. Cells were resuspended in four times the packed cell volume of hypotonic buffer (10 mM Tris-HCl, pH 7.4, 1 mM MgCl 2 , 1 mM EDTA, 1.5 mM PMSF, 0.5 mM...

.... , Serrador   J. M. , Sánchez–Madrid   F. ( 1999 ). Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes.   Eur. J. Immunol.   29 , 3609 – 3620 . 10.1002/(SICI)1521-4141(199911)29:11<3609::AID-IMMU3609>3.0.CO;2-S Dovas...

...) and/or adjacent cells. This process is dependent on transcellular cell–ECM or cell–cell adhesions, as well as cell contractility mediated by Rho GTPases, to provide a functional linkage through which forces are transmitted through the cytoskeleton by intracellular force-generating proteins. This Commentary covers...

... not resolve these dimensions. New imaging technologies now allow the visualization of Rho GTPase signaling with high spatio-temporal resolution. This has led to insights that significantly extend classic models and call for a novel conceptual framework. These approaches clearly show three things. First, Rho...

... 2010. 2010 Actin stress fibers Stress fibres Formin Rho GTPase Contractile Actin stress fibers are long contractile bundles of actin filaments and myosin II that span the body of non-muscle cells. Their organization is broadly similar to that of the sarcomeric arrays of muscle cells...

[email protected] ) 9 11 2009 © 2010. 2010 Pollen tube Tip growth Rho GTPase The formation of elongated tubular cells is a critical developmental process required for a number of eukaryotic cells to perform their characteristic functions: (1) neurons differentiate, producing long axons...