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Keywords: Rho
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Journal Articles
J Cell Sci (2017) 130 (6): 1169–1178.
Published: 15 March 2017
... financial interests. 7 10 2016 1 2 2017 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Yeast resists plasma membrane stress by maintaining the cortical localization of Rho GTPase through lipid remodeling mediated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 2957–2964.
Published: 15 August 2015
... phosphatidylinositol 4,5-bisphosphate PI(4,5) P 2 and the Rho family of small GTPases ( Guo et al., 2001 ; Zhang et al., 2001 , 2008). Moreover, regions of Sec5 and Exo84 have been crystalized in complex with the GTPase Ral ( Mott et al., 2003 ; Fukai et al., 2003 ; Jin et al., 2005 ). In addition to the holo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2047–2056.
Published: 01 June 2015
...Shinichiro Nakahara; Koji Tsutsumi; Takuya Zuinen; Yasutaka Ohta ABSTRACT Rho family small GTPases are essential for the formation of adherens junctions in epithelial cells. Here, we found that FilGAP (also known as ARHGAP24), a Rac-specific Rho GTPase-activating protein, promoted the formation of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 50–60.
Published: 01 January 2015
... equally to this work. ‡ Author for correspondence ( pts7h@virginia.edu ) Competing interests The authors declare no competing interests. 19 02 2014 27 10 2014 © 2015. Published by The Company of Biologists Ltd 2015 p190RhoGAP Anillin Myosin II Cytokinesis Rho...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2765–2774.
Published: 01 June 2012
... completely. Simultaneous imaging of the vesicle membrane and the actin coat revealed that contraction of the actin coat compresses the vesicle following fusion. This leads to active extrusion of vesicle contents. Initial actin coating of fused vesicles is dependent on activation of Rho and formin-dependent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 108–120.
Published: 01 January 2012
...Satoko Sakamoto; Toshimasa Ishizaki; Katsuya Okawa; Sadanori Watanabe; Takatoshi Arakawa; Naoki Watanabe; Shuh Narumiya Regulation of the actin cytoskeleton is crucial for cell morphology and migration. mDia is an actin nucleator that produces unbranched actin filaments downstream of Rho. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1077–1087.
Published: 01 April 2011
...Hye-Jin Shin; Seung Bae Rho; Dae Chul Jung; Inn-Oc Han; Eok-Soo Oh; Joo-Young Kim Expression of carbonic anhydrase IX (CA9) was shown to be strongly involved in high incidences of metastasis and poor prognosis in various human tumors. In this study, we investigated the possible role for CA9 in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1007–1013.
Published: 01 April 2010
... summarizes some of these recent discoveries that are relevant to the control of biological responses of the cell. FAK Pyk2 Rho Cell migration Microtubules Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that plays an essential role during embryonic development and in the...
Journal Articles
J Cell Sci (2009) 122 (22): 4049–4061.
Published: 15 November 2009
... cadherins and Rho-family GTPases. * Author for correspondence ( pdmccrea@mdanderson.org ) 2 9 2009 © The Company of Biologists Limited 2009 2009 Gastrulation Rho Rac Vertebrate catenins are related to Drosophila Armadillo (with the exception of α-catenin), and associate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (13): 2263–2273.
Published: 01 July 2009
... E-cadherin Rho α3β1 integrin Tetraspanins, a family of proteins with 33 members in mammals, play important roles in gamete fusion, brain development and function, immunity, photoreceptor morphology, and the maintenance of epidermal integrity ( Hemler, 2005 ; Levy and Shoham, 2005 ). In...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 1939–1946.
Published: 15 June 2009
..., such as the adaptor TNF-receptor-associated factor 4 and the ectodysplasin A receptor (and its ligand and adaptors), have dedicated morphogenetic roles. The mechanism by which TNF signalling affects cell shape is not yet fully understood, but Rho-family GTPases have a central role. The fact that the...
Journal Articles
J Cell Sci (2008) 121 (20): 3403–3412.
Published: 15 October 2008
... a several fold increase in free G-actin along with an increase in total G-actin. These results indicate that in cells, the actin nucleation frequency of mDia1 is enhanced not only by Rho, but also strongly through increased catalytic efficiency of the FH2 domain. Consistently, frequent actin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2452–2462.
Published: 01 August 2008
... stress fibers, causing a typical elongated, contractile morphology. Extensive remodeling of adhesions in fibroblasts also takes part in fibronectin fibrillogenesis, a process that depends on Rho-mediated contractility and results in the formation of a fibronectin matrix. Our current study shows that all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (14): 2350–2359.
Published: 15 July 2008
... by FRAP. Complete microtubule disassembly or selective loss of astral microtubules resulted in wave-like contractile behavior of actin in the non-equatorial cortex, and mislocalization of myosin II and Rho. FRAP experiments showed that both contractility and actin polymerization contributed to the...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (10): 1739–1749.
Published: 15 May 2008
... suppress cellular transformation by preventing sustained Rho activation in concert with restricting RhoA and Lbc binding via its BCH domain. This could provide a general mechanism for regulating RhoGEFs and their target GTPases. * Author for correspondence (e-mail: dbslowbc@nus.edu.sg ) 13 2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3138–3146.
Published: 01 September 2007
... Cdc42 Rho Lamellipodia Cell migration is an essential property of cells engaged in embryogenesis, inflammation, wound healing and tumor metastasis. Motility toward a source of chemoattractant depends on localized extension of actin-rich protrusions, such as lamellipodia. Studies with...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (11): 1859–1867.
Published: 01 June 2007
.... Indeed, TTC3 overexpression leads to strong inhibition of neurite extension, which can be reverted by CIT-K RNAi. Conversely, TTC3 knockdown stimulates neurite extension in the same cells. Finally, we find that Rho, but not Rho kinase, is required for TTC3 differentiation-inhibiting activity. Our results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (11): 1927–1934.
Published: 01 June 2007
...Ya-yu Chuang; Aline Valster; Salvatore J. Coniglio; Jonathan M. Backer; Marc Symons Wrch-1 (Wnt-regulated Cdc42 homolog) is a new member of the Rho family that was identified as a gene transcriptionally upregulated by Wnt-1. Wrch-1 has no detectable GTPase activity and displays very high intrinsic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 456–467.
Published: 01 February 2007
...Akiko Mammoto; Sui Huang; Donald E. Ingber Cytoskeleton-dependent changes in the activity of the small GTPase Rho mediate the effects of cell shape on cell function; however, little is known about how cell spreading and related distortion of the cytoskeleton regulate Rho activity. Here we show that...
Journal Articles
J Cell Sci (2006) 119 (22): 4650–4666.
Published: 15 November 2006
... could be restored with wild-type recombinant ARAP2 but not mutants lacking ArfGAP or Rho-binding activity. Constitutively active Arf6 also caused a loss of SFs. The Rho effector ROKα was ineffective in restoring FAs. Conversely, overexpression of ARAP2 did not restore SFs in cells treated with a ROK...