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Keywords: Retromer
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (10): jcs259396.
Published: 17 May 2022
...Shuwei Xie; Carter Dierlam; Ellie Smith; Ramon Duran; Allana Williams; Angelina Davis; Danita Mathew; Naava Naslavsky; Jyoti Iyer; Steve Caplan ABSTRACT The mammalian retromer consists of subunits VPS26 (either VPS26A or VPS26B), VPS29 and VPS35, and a loosely associated sorting nexin (SNX...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs246819.
Published: 24 December 2020
... to the trans-Golgi network (TGN). At high copper, ATP7B colocalizes with endolysosomal markers and with a core member of retromer complex, VPS35. Knocking down VPS35 did not abrogate the copper export function of ATP7B or its copper-responsive anterograde trafficking to vesicles; rather upon subsequent copper...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs249201.
Published: 25 August 2020
...Rachel Curnock; Peter J. Cullen ABSTRACT The concentration of essential micronutrients, such as copper (used here to describe both Cu + and Cu 2+ ), within the cell is tightly regulated to avoid their adverse deficiency and toxicity effects. Retromer-mediated sorting and recycling of nutrient...
Journal Articles
J Cell Sci (2020) 133 (15): jcs246033.
Published: 3 August 2020
...Ashley J. Evans; James L. Daly; Anis N. K. Anuar; Boris Simonetti; Peter J. Cullen ABSTRACT Human retromer, a heterotrimer of VPS26 (VPS26A or VPS26B), VPS35 and VPS29, orchestrates the endosomal retrieval of internalised cargo and promotes their cell surface recycling, a prototypical cargo being...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs234047.
Published: 16 March 2020
... CLN3 and Rab7A, a small GTPase that regulates several functions at late endosomes. We confirmed this interaction in live cells and found that CLN3 is required for the efficient endosome-to-TGN trafficking of the lysosomal sorting receptors because it regulates the Rab7A interaction with retromer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs223586.
Published: 15 February 2019
...: A conserved function for RAB-6.2 in epidermis integrity in C. elegans . The mechanism of action in the skin is independent from that previously described for this protein in retrograde trafficking. RAB-6.2 Epidermis Retromer RAB6 Exocyst Intracellular trafficking is crucial for development...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs211672.
Published: 10 September 2018
... and evolutionarily conserved role in the sorting and transport of numerous transmembrane proteins is the endosomal network ( Huotari and Helenius, 2011 ; Burd and Cullen, 2014 ; Klumperman and Raposo, 2014 ). Huntingtin Retromer Septin Sorting nexin Summary: A potential scaffolding function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs218610.
Published: 17 August 2018
... that the effect of this phosphorylation of SNX27 phenocopies the effects seen upon loss of SNX27 function, affecting PM trafficking of cargo proteins that bind SNX27–retromer. Additionally, CT destabilizes retromer function by decreasing the amount of core retromer proteins. These effects of CT can be partially...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs217398.
Published: 21 June 2018
...Matthew N. J. Seaman; Aamir S. Mukadam; Sophia Y. Breusegem ABSTRACT The retromer complex is a vital component of the endosomal protein sorting machinery necessary for sorting into both the endosome-to-Golgi retrieval pathway and also the endosome-to-cell-surface recycling pathway. Retromer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs211342.
Published: 6 June 2018
... of the polycystins through the biosynthetic and endosomal membrane networks remain to be fully elucidated. Here, we describe an interaction between PC2 and retromer, a master controller for the sorting of integral membrane proteins through the endo-lysosomal network. We show that association of PC2 with retromer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs203695.
Published: 29 January 2018
... of cargo proteins, mediated by the retromer complex. Recent work has led to significant progress in understanding the role of Arabidopsis retromer subunits in recycling vacuolar sorting receptors and plasma membrane proteins. As a consequence, members of the sorting nexin (SNX) protein family...
Journal Articles
J Cell Sci (2017) 130 (16): 2707–2721.
Published: 15 August 2017
... in evolution, such as retromer, which is involved in the recycling of a diverse set of cargoes via the retrograde trafficking route. Here, in an RNAi-based loss-of-function study, we identified that suppression of SNX12 leads to a severe blockage in CIM6PR (also known as IGF2R) transport and alters...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2579–2590.
Published: 1 August 2017
...Graziana Modica; Olga Skorobogata; Etienne Sauvageau; Adriano Vissa; Christopher M. Yip; Peter K. Kim; Hugo Wurtele; Stephane Lefrancois ABSTRACT Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (14): 2359–2370.
Published: 15 July 2017
... mechanism for EHD1 function. Recent studies have demonstrated that VPS35 and the retromer complex influence mitochondrial homeostasis either by Mul1-mediated ubiquitylation and degradation of the fusion protein Mfn2, or by removal of inactive Drp1 from the mitochondrial membrane. We demonstrate that EHD1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 382–395.
Published: 15 January 2017
...Arunas Kvainickas; Ana Jimenez Orgaz; Heike Nägele; Britta Diedrich; Kate J. Heesom; Jörn Dengjel; Peter J. Cullen; Florian Steinberg ABSTRACT Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 645–655.
Published: 15 February 2015
...Henning Arlt; Fulvio Reggiori; Christian Ungermann ABSTRACT Endosomes are dynamic organelles that need to combine the ability to successfully deliver proteins and lipids to the lysosome-like vacuole, and recycle others to the Golgi or the plasma membrane. We now show that retromer, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 373–384.
Published: 15 January 2015
...Zhi-Hui Deng; Timothy S. Gomez; Douglas G. Osborne; Christine A. Phillips-Krawczak; Jin-San Zhang; Daniel D. Billadeau ABSTRACT The pentameric WASH complex is best known for its role in regulating receptor trafficking from retromer-rich endosomal subdomains. FAM21 functions to stabilize the WASH...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4940–4953.
Published: 15 November 2014
...Ian J. McGough; Florian Steinberg; Matthew Gallon; Ayaka Yatsu; Norihiko Ohbayashi; Kate J. Heesom; Mitsunori Fukuda; Peter J. Cullen ABSTRACT Retromer is a protein assembly that orchestrates the sorting of transmembrane cargo proteins into endosome-to-Golgi and endosome-to-plasma-membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2053–2070.
Published: 1 May 2014
...Caroline L. Freeman; Geoffrey Hesketh; Matthew N. J. Seaman ABSTRACT Retromer is a vital element of the endosomal protein sorting machinery and comprises two subcomplexes that operate together to sort membrane proteins (cargo) and tubulate membranes. Tubules are formed by a dimer of sorting nexins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4963–4973.
Published: 1 November 2013
... the Retromer-mediated process ( Hettema et al., 2003 ). Mutation of the sorting nexin subunit Atg24 (also called Snx4) disrupts API processing under nutrient-rich conditions ( Nice et al., 2002 ). When the sorting nexin mutation atg24 was introduced into the TRAPPIII ( trs85 ) mutant, the phenotype...
Includes: Supplementary data