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Keywords: Retrograde transport
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Journal Articles
J Cell Sci (2016) 129 (8): 1537–1545.
Published: 15 April 2016
... affect their trafficking between the ER and the Golgi in the forward and backward directions. Anterograde transport Retrograde transport Cargo capture Membrane proteins Partitioning Sorting signals Twenty to thirty years ago, a handful of seminal studies ( Wieland et al., 1987...
Journal Articles
J Cell Sci (2015) 128 (16): 3131–3142.
Published: 15 August 2015
... are important sorting stations for some retrograde cargo. SMAP2, a GTPase-activating protein (GAP) for Arf1 with a putative clathrin-binding domain, has previously been shown to participate in the retrograde transport of the cholera toxin B-subunit (CTxB) from recycling endosomes. Here, we found that clathrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2825–2839.
Published: 1 July 2014
... delays Brefeldin-A-induced Golgi-to-ER retrograde transport, phenocopying cells with mutations or silencing of the conserved oligomeric Golgi (COG) complex. Co-immunoprecipitation and in vitro binding experiments reveals that TMEM115 interacts with the COG complex, and might self-interact to form dimers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3552–3562.
Published: 15 August 2013
...: some is recycled to the plasma membrane via Rab11-labelled recycling endosomes; the remaining PrP Sc is subject to retromer-mediated retrograde transport to the Golgi. This pathway leads to lysosomal degradation, and we show that this is the dominant PrP Sc degradative mechanism in the early stages...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (14): 2401–2413.
Published: 15 July 2011
.... Overall, these data show that furin uses the Rab9-dependent pathway from late endosomes and that retrograde transport directly from early endosomes is dependent on both the transmembrane domain and the cytoplasmic tail. References Amessou M. , Fradagrada A. , Falguieres T. , Lord...
Includes: Supplementary data
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J Cell Sci (2009) 122 (20): 3703–3714.
Published: 15 October 2009
... of the endosomal β-cleavage pathway reduces translocation of AICD to these nuclear AFT complexes. AICD signaling further depends on active transport along microtubules and can be modulated by interference with both anterograde and retrograde transport systems. Nuclear signaling by endogenous AICD in primary...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2009) 122 (3): 389–400.
Published: 1 February 2009
...-mail: [email protected] ) 23 10 2008 © The Company of Biologists Limited 2009 2009 EHD3 Early endosome Golgi Retrograde transport Mannose-6-phosphate receptor The transport of membranes and proteins through the endocytic pathways is a highly regulated process controlled by several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (8): 1293–1302.
Published: 15 April 2008
... vesicles with the ER in retrograde transport remains elusive. Here, we show that in yeast Ypt1p is essential for retrograde transport from the Golgi to the ER. Retrieval of gpαF-HDEL (glycolylated pro-α-factor with an HDEL tag at the C-terminus) was blocked in Δ ypt1/SLY1-20 membranes at the restrictive...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2007) 120 (12): 2022–2031.
Published: 15 June 2007
...-subunit, a well-studied retrograde transport cargo. As previously described for clathrin, we find that interfering with Vps26 expression inhibits retrograde transport of the Shiga toxin B-subunit to the TGN. Under these conditions, endosomal tubules that take the Shiga toxin B-subunit out of transferrin...
Includes: Multimedia, Supplementary data
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Journal Articles
J Cell Sci (2003) 116 (17): 3503–3510.
Published: 1 September 2003
...Alice Chen; Ramzey J. AbuJarour; Rockford K. Draper Cholera toxin, Shiga toxin and ricin are examples of protein toxins that require retrograde transport from the Golgi complex into the endoplasmic reticulum (ER) to express their cytotoxic activities and different toxins appear to use different...
Journal Articles
J Cell Sci (1999) 112 (22): 4135–4142.
Published: 15 November 1999
... proteins can be trapped in the ER. * Author for correspondence 03 11 1999 01 09 1999 © 1999 by Company of Biologists 1999 Bet1p Bos1p ER-Golgi v -SNARE Retrograde transport COPI The machineries that mediate the bidirectional transport between the endoplasmic...
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J Cell Sci (1998) 111 (11): 1507–1520.
Published: 1 June 1998
..., very little of this protein is cleaved by Kex2p. Efficient cleavage, however, occurs in mutants defective in the retrograde transport of different ER-resident proteins indicating that Sec22-α rapidly reaches the late Golgi of these cells. These mutants ( sec20-1, sec21-1, sec27-1 and ufe1-1 ) reveal...
Journal Articles
J Cell Sci (1995) 108 (4): 1805–1815.
Published: 1 April 1995
... in untreated cells. These data suggest a regulatory role for both αs and αi trimeric G proteins in the normal Golgi-ER retrograde transport taking place in intact cells. * Author for correspondence 09 09 1994 09 12 1994 © 1995 by Company of Biologists 1995 Golgi complex...
Journal Articles
J Cell Sci (1994) 107 (3): 529–537.
Published: 1 March 1994
... whether MG160 acquires sialic acid residues in the trans cisternae or trans -Golgi network (TGN) prior to its retrograde transport, we have examined the effects of brefeldin A (BFA) on the post-translational processing of MG160, and the distribution of internalized wheat germ agglutinin covalently linked...