... organizer CTCF in differentially regulating the organization and function of the HOXA gene locus during differentiation. Nucleoporins Nup93 CTCF CBS HOXA Chromatin Retinoic acid Differentiation Science and Engineering Research Board http://dx.doi.org/10.13039/501100001843 CRG...

... for the broad range of cellular functions of the protein is incompletely understood. We show that HuR controls the expression of multiple components of the nuclear import machinery. Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA...

... differentiation was unknown. Here, we show that stabilized HRas specifically induces neuronal differentiation of NSCs. Lentivirus-mediated HRas overexpression and knockdown resulted in stimulation and inhibition, respectively, of NSC differentiation into neuron in the ex vivo embryo. Retinoic acid, an active...

...Ziad Al Tanoury; Samia Gaouar; Aleksandr Piskunov; Tao Ye; Sylvia Urban; Bernard Jost; Céline Keime; Irwin Davidson; Andrée Dierich; Cécile Rochette-Egly ABSTRACT Retinoic acid (RA) plays key roles in cell differentiation and growth arrest by activating nuclear RA receptors (RARs) (α, β and γ...

...Ziad Al Tanoury; Aleksandr Piskunov; Dina Andriamoratsiresy; Samia Gaouar; Régis Lutzing; Tao Ye; Bernard Jost; Céline Keime; Cécile Rochette-Egly ABSTRACT Nuclear retinoic acid (RA) receptors (RARα, β and γ) are ligand-dependent transcription factors that regulate the expression of a battery...

... activity is associated with increased viability of human myoblasts. In addition to its detoxifying activity, aldehyde dehydrogenase can also catalyze the irreversible oxidation of vitamin A to retinoic acid; therefore, we examined whether retinoic acid is important for myoblast viability. We showed...

... and molecular processes involved is crucial for the treatment of human pathologies, where abnormal skin development and barrier dysfunction are associated with hypothermia and perinatal dehydration. For the first time, we demonstrate that retinoic acid (RA) levels are important for periderm desquamation...

...Tomonobu Sato; Fumihiko Okumura; Satoshi Kano; Takeshi Kondo; Tadashi Ariga; Shigetsugu Hatakeyama Retinoic acid (RA), a metabolite of vitamin A, plays versatile roles in development, differentiation, cell cycles and regulation of apoptosis by regulating gene transcription through nuclear receptor...

...Helen J. Dranse; Arthur V. Sampaio; Martin Petkovich; T. Michael Underhill Cyp26b1 , a retinoic acid (RA)-metabolising enzyme, is expressed in the developing limb bud, and Cyp26b1 −/− mice present with severe limb defects. These malformations might be attributable to an RA-induced patterning defect...

... of adipogenic differentiation. Instead, we demonstrate a novel role for P311 in an alternative pathway of lipid-droplet accumulation that is induced by the regeneration-inducing molecule retinoic acid. We next determined whether P311 expression is required for retinoic-acid-mediated lipid accumulation...

...Jau-Cheng Liou; Shih-Yin Ho; Meng-Ru Shen; Yi-Ping Liao; Wen-Tai Chiu; Kai-Hsiang Kang We have previously shown that retinoic acid (RA), a factor highly expressed in spinal cord, rapidly and specifically enhances the spontaneous acetylcholine release at developing neuromuscular synapses in Xenopus...

...Yi-Ping Liao; Shih-Yin Ho; Jau-Cheng Liou Although the long-term effects of all-trans retinoic acid (RA) on neuronal growth and differentiation have been intensively studied, nothing is known about its effect on synaptic transmission. Here we show that RA rapidly and specifically enhances...

...Robert A. McCarthy; W. Scott Argraves Megalin is a receptor expressed by embryonic epithelia that mediates endocytosis of numerous ligands, including sonic hedgehog (Shh) and retinol,the precursor to retinoic acid (RA). The importance of Shh and RA signaling in neurodevelopment, combined...

... with motoneuron disease. These effects are mediated through the retinoic acid receptor α. The same receptor deficit is found in motoneurons from patients suffering from spontaneous amyotrophic lateral sclerosis. Furthermore, we show that there is a loss of expression of the retinaldehyde dehydrogenase enzyme II...

...Jonathan Corcoran; Braham Shroot; John Pizzey; Malcolm Maden ABSTRACT Dorsal root ganglion (DRG) neurons can be categorised into at least three types, based upon their neurotrophin requirement for survival. We have analysed the expression of the retinoic acid receptors (RARs) and the retinoid X...

... to changes in proliferation and differentiation. We show here that retinoic acid (RA) affects the expression of these keratins differently in myogenic cells originated from normal limb and limb blastema. Furthermore, we find that the effects of RA on proliferation, myogenic differentiation and adhesion...

...Michelina Plateroti; Jean-Noël Freund; Cathy Leberquier; Michèle Kedinger ABSTRACT In previous experiments we showed that intestinal development was dependent upon epithelial-mesenchymal cell interactions. The aim of this study was to investigate the possible role of retinoic acid (RA...

... and absence of serum. In serum-free conditions, OP-1 promoted cell proliferation and chondrocyte maturation, without requiring either thyroid hormone or insulin, agents known to support chick chondrocyte differentiation in vitro. When grown in agarose under the same conditions, TGF-β 1 and retinoic acid...

...-dependent expression was found with cyclins A (S+G 2 ), B (G 2 ) and E (late G 1 and S), while other cell cycle genes showed only very weak (cdk2) or no periodic expression (cyclin D1, cyclin D2 and cdk4). Induction of macrophage-like differentiation by TPA or granulocytic differentiation by retinoic acid...

...Christine Roméro; Edith Aberdam; Catherine Larnier; Jean-Paul Ortonne ABSTRACT Retinoic acid (RA) is a hormone-like agent involved in the control of cell differentiation. The most characteristic feature of melanocyte differentiation, melanogenesis, is stimulated by UV radiations. Excessive chronic...