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Keywords: Reprogramming
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (11): jcs259824.
Published: 10 June 2022
...-methyladenosine (m 6 A) demethylase ALKBH5 regulates somatic cell reprogramming in a stage-specific manner through its catalytic activity. Knockdown or knockout of Alkbh5 in the early reprogramming phase impairs reprogramming efficiency by reducing the proliferation rate through arresting the cells at G2/M phase...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2019) 132 (20): jcs232223.
Published: 22 October 2019
...Lotte Vanheer; Juan Song; Natalie De Geest; Adrian Janiszewski; Irene Talon; Caterina Provenzano; Taeho Oh; Joel Chappell; Vincent Pasque ABSTRACT Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripotent stem cells (iPSCs). However, the mediators...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (12): 2018–2025.
Published: 15 June 2017
... ability to grow or reprogram non-mammary cells in transplanted mammary fat pads. AREG −/− mammary cells were capable of redirecting both types of non-mammary cell populations to mammary phenotypes in regenerating mammary outgrowths. Transplantation of fragments from AREG-reprogrammed chimeric outgrowths...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2303–2318.
Published: 1 July 2015
...: The transcription factors Brn2 and Zic1 cooperate to regulate the neurogenic gene expression programme of retinoic-acid-treated mouse embryonic stem cells. Ascl1 Fgf2 Sox2 ChIP-seq Reprogramming Retinoic acid plays an essential role in embryonic development and in the homeostasis of many adult...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 81–87.
Published: 1 January 2015
...Jong Soo Kim; Hyun Woo Choi; Marcos J. Araúzo-Bravo; Hans R. Schöler; Jeong Tae Do ABSTRACT Direct reprogramming of somatic cells to pluripotent stem cells entails the obliteration of somatic cell memory and the reestablishment of epigenetic events. Induced pluripotent stem cells (iPSCs) have been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3998–4008.
Published: 15 September 2014
...Yong Tang; Zongliang Jiang; Yan Luo; Xueming Zhao; Ling Wang; Carol Norris; Xiuchun Cindy Tian ABSTRACT Akt plays an important role in cell growth, proliferation and survival. The specific roles of the three Akt isoforms in somatic cell reprogramming have not been investigated. Here we report...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2516–2524.
Published: 1 June 2013
... as pluripotent embryonic stem cells (ESCs). iPSCs reprogrammed from differentiated cells undergo epigenetic modification during reprogramming, and ultimately acquire a similar epigenetic state to that of ESCs. In this study, these epigenetic changes were observed in reprogramming of uniparental parthenogenetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1093–1098.
Published: 1 March 2013
...Chih-I Tai; Qi-Long Ying Summary Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal and also facilitates reprogramming to ground state pluripotency. Exactly how LIF/Stat3 signaling...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 1 December 2012
... reprogramming. Determining how energy metabolism regulates stem cell fate should shed light on the decline in tissue regeneration that occurs during aging and facilitate the development of therapies for degenerative or metabolic diseases. * Author for correspondence ( anne.brunet@stanford.edu ) © 2012...
Journal Articles
J Cell Sci (2012) 125 (23): 5609–5620.
Published: 1 December 2012
... achievements of cellular reprogramming have enabled the generation of induced pluripotent stem cells (iPSCs) or other lineage-committed cells from more accessible and abundant somatic cell types by defined genetic factors. However, serious concerns remain about the efficiency and safety of current genetic...
Journal Articles
J Cell Sci (2012) 125 (18): 4179–4787.
Published: 15 September 2012
... of this reprogramming technology not only makes it possible to perform basic research on human stem cells that do not have to be derived from embryos, but also allows patient-specific cells and tissues to be generated for therapeutic use. Optimizing this process will probably lead to a better and more efficient means...
Journal Articles
J Cell Sci (2012) 125 (11): 2553–2560.
Published: 1 June 2012
... include differentiation and senescence. However, recent studies have shown that it is possible to influence cell fate through artificial manipulation. For example, the exogenous expression of a set of transcription factors can result in the reprogramming of differentiated skin fibroblasts to a pluripotent...
Journal Articles
J Cell Sci (2011) 124 (3): 405–413.
Published: 1 February 2011
... for correspondence ( m.c.wright@ncl.ac.uk ) 28 9 2010 © 2011. 2011 Dexamethasone Stem cell Reprogramming LY294002 Liver Pancreas Transdifferentiation is a form of metaplasia and describes the irreversible switching of cellular differentiation in fully differentiated cells ( Burke...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4122–4129.
Published: 15 November 2009
...Jeong Tae Do; Dong Wook Han; Luca Gentile; Ingeborg Sobek-Klocke; Anton Wutz; Hans R. Schöler The fusion of somatic cells with pluripotent cells results in the generation of pluripotent hybrid cells. Because the `memory' of somatic cells seems to be erased during fusion-induced reprogramming...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3502–3510.
Published: 1 October 2009
... demonstrate that a mouse malignant melanoma cell line, which has previously been reprogrammed into embryonic stem cells by nuclear transfer, remains equally amenable to reprogramming into iPSCs by these transcription factors. In contrast to skin fibroblasts, melanocytes and melanoma cells did not require...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 1045–1053.
Published: 1 April 2009
...Jason H. Pomerantz; Semanti Mukherjee; Adam T. Palermo; Helen M. Blau Fusion of mammalian cells to form stable, non-dividing heterokaryons results in nuclear reprogramming without the exchange of genetic material. In this report, we show that reprogramming in somatic cell heterokaryons involves...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (10): 2065–2072.
Published: 15 May 2006
.... Interestingly, erasing lymphocyte identity in reprogrammed cells requires histone deacetylase (HDAC) activity. Inhibition of HDAC activity during reprogramming selectively blocks the silencing of lymphocyte-specific genes but does not prevent the establishment of muscle-specific gene expression. Successful...
Includes: Supplementary data