...Atanu Ghorai; Bhawna Singh; Shilpee Dutt ABSTRACT Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, but the mechanism of TIS manifestation remains obscure. Here, we demonstrate that replication stress (RS) is critical...

... attributed. Highlighted Article: The human oncoprotein DEK forms nuclear bodies that are regulated by the SUMO pathway and localize to active sites of constitutive heterochromatin replication. Oncogene Breast cancer Replication stress Histone modification Superresolution microscopy siRNA...

... mice, suggesting a link between oxidative stress and CIN. As a cause of CIN, we found that cells from aged mice are under replication stress, which was ameliorated by antioxidant treatments. Microtubule stabilization is a potential cause of CIN promoted by replication stress. Our data demonstrate...

... structure. We have discovered that SAF-A supports DNA replication at multiple steps. DNA replication Chromatin Replication stress Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 Daiwa Anglo-Japanese Foundation 12928/13746...

...Emily Feng; Nicole L. Batenburg; John R. Walker; Angus Ho; Taylor R. H. Mitchell; Jian Qin; Xu-Dong Zhu ABSTRACT Elevated replication stress is evident at telomeres of about 10-15% of cancer cells, which maintain their telomeres via a homologous recombination (HR)-based mechanism, referred...

... titration artifacts seen upon NIPP1 overexpression, we have engineered covalently linked fusions of PP1 and NIPP1, and demonstrate their potential to selectively explore the function of the PP1:NIPP1 holoenzyme. By using inducible stable cell lines, we show that PP1–NIPP1 fusions cause replication stress...

..., the increased E2F1 activity promoted cellular proliferation by stimulating the genes involved in cell cycle control and replication. However, during the late stages, E2F1 triggered replication-stress-induced DNA damage and sensitized cells to apoptotic death in a p53-independent manner. Interestingly...

... an unexpected delay in G2/M cell cycle progression and aneuploidy. In investigating the underlying molecular mechanism, we revealed that inhibiting Drp1 triggers replication stress, which is mediated by a hyperfused mitochondrial structure and unscheduled expression of cyclin E in the G2 phase. This persistent...

...Vitaly M. Vassin; Rachel William Anantha; Elena Sokolova; Shlomo Kanner; James A. Borowiec ATR is an essential kinase activated in response to DNA-replication stress, with a known target being the RPA2 subunit of human replication protein A (RPA). We find that S33-RPA2 phosphorylation by ATR occurs...

...Karoline C. Manthey; Stephen Opiyo; Jason G. Glanzer; Diana Dimitrova; James Elliott; Gregory G. Oakley Post-translational phosphorylation of proteins provides a mechanism for cells to switch on or off many diverse processes, including responses to replication stress. Replication-stress-induced...