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Keywords: Regulation
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Journal Articles
J Cell Sci (2018) 131 (9): jcs215509.
Published: 08 May 2018
... by a family of six conserved genes. Although these genes have evolved independently for more than 100 million years, they encode proteins with ≥94% sequence identity, which are differentially expressed in different tissues, and tightly regulated throughout embryogenesis and adulthood. It has been previously...
Journal Articles
J Cell Sci (2019) 132 (4): jcs208199.
Published: 19 April 2018
... reported the establishment of an in vitro GBF1 recruitment assay that supports the regulation of GBF1 recruitment by Arf-GDP. This in vitro assay yielded further evidence for the requirement of a Golgi-localized protein because heat denaturation or protease treatment of Golgi membranes abrogated GBF1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 717–728.
Published: 15 February 2016
... of Biologists Ltd 2016 Summary: ATF6a, a target of the Runx2 and Sox6 transcription factors, positively regulates hypertrophic chondrocyte differentiation and endochondral bone formation by acting as a coactivator of Runx2. ATF6a Chondrocyte hypertrophy UPR Transcription factor Regulation...
Journal Articles
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Autophagy
J Cell Sci (2016) 129 (1): 135–144.
Published: 01 January 2016
... kinases in the yeast genome, we newly identified a regulator of autophagy, the Ccl1–Kin28 kinase complex (the equivalent of the mammalian cyclin-H–Cdk7 complex), which is known to play key roles in RNA-polymerase-II-mediated transcription. We show that inactivation of Ccl1 caused complete block...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2095–2104.
Published: 01 May 2012
..., the mechanisms by which anterograde and retrograde movement are coordinated with one another and with stationary axonal mitochondria are not yet understood. In this Commentary, we review why mitochondria move and how they move, focusing particularly on recent studies of transport regulation, which implicate...
Journal Articles
J Cell Sci (2006) 119 (15): 3227–3237.
Published: 01 August 2006
... (e-mail: p.j.hussey@durham.ac.uk ) * These authors contributed equally to this work 17 5 2006 © The Company of Biologists Limited 2006 2006 Microtubule-associated protein MAP-65 Division midzone Regulation Microtubule organisation undergoes dramatic spatial...
Journal Articles
J Cell Sci (2006) 119 (4): 646–658.
Published: 15 February 2006
...Zohra Rahmani The Src nonreceptor tyrosine kinase plays an important role in multiple signalling pathways that regulate several cellular functions including proliferation, differentiation and transformation. The activity of Src is tightly regulated in vivo and can be modulated by interactions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (2): 369–379.
Published: 15 January 2005
... investigated how calcium-induced changes in traction stress are correlated with cell speed and shape during the mechano-chemical feedback regulation of keratocyte movement. Cyclic changes in traction stress, cell speed and shape were associated with single calcium transients. In addition, an inverse...
Journal Articles
J Cell Sci (2002) 115 (21): 4107–4115.
Published: 01 November 2002
...Sourav Ghosh; Frank C. Dorsey; John V. Cox Previous analyses have shown that the phosphorylation state of chicken erythroid ankyrin regulates its association with the spectrin cytoskeleton in vivo. Treatment of erythroid cells with serine and threonine phosphatase inhibitors stimulates...
Journal Articles
J Cell Sci (2002) 115 (10): 2021–2029.
Published: 15 May 2002
... association for all three isoforms, indicating a negative regulatory role for the unique tail regions. We have tested this hypothesis by constructing a series of deletion and substitution mutants for all three CaP isoforms. Here we demonstrate that the C-terminal sequences regulate actin association...
Journal Articles
J Cell Sci (1996) 109 (11): 2613–2618.
Published: 01 November 1996
...A. Paul Mould © 1992 by Company of Biologists 1992 Integrin Regulation Conformational state Allostery REFERENCES Alemany M. , Concord E. , Garin J. , Vinçon M. , Marguerie G. , Gulino D. ( 1996 ). Sequence 274–368 in the3 subunit of the integrin...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 81–87.
Published: 01 January 1994
.... Mutational studies have shown that E1A’s oncogenic ability is determined primarily by its ability to bind to certain cellular proteins and interfere with their function. One of these cellular targets for E1A is the product of the retinoblastoma tumor suppressor gene, pRB. pRB is a negative regulator of cell...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_11): 1–11.
Published: 01 January 1989
... proteins can penetrate across both mitochondrial membranes and how some of these proteins can regulate the expression of specific mitochondrial genes. y. Cell Set. Suppl. ¡1, 1-11 (1989) Printed in Great Britain © The Company of Biologists Limited 1989 1 Interaction between mitochondria and the nucleus L...
Journal Articles
J Cell Sci (1988) 1988 (Supplement_10): 181–194.
Published: 01 February 1988
... in Great Britain @ The Company o f Biologists L im ited 1988 181 Regulation of the proliferation of spermatogonial stem cells D. G. DE R OO I J Department of Cell Biology, State University of Utrecht, Medical School, Utrecht, The Netherlands Summary The proliferating cells in the seminiferous epithelium...