...Toni McHugh; Julie P. I. Welburn ABSTRACT The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances...

... by a family of six conserved genes. Although these genes have evolved independently for more than 100 million years, they encode proteins with ≥94% sequence identity, which are differentially expressed in different tissues, and tightly regulated throughout embryogenesis and adulthood. It has been previously...

... reported the establishment of an in vitro GBF1 recruitment assay that supports the regulation of GBF1 recruitment by Arf-GDP. This in vitro assay yielded further evidence for the requirement of a Golgi-localized protein because heat denaturation or protease treatment of Golgi membranes abrogated GBF1...

... and molecular interactions regulating skeletogenesis . J. Cell. Biochem.   95 , 688 - 697 . 10.1002/jcb.20449 Cui , C. B. , Cooper , L. F. , Yang , X. , Karsenty , G. and Aukhil , I. ( 2003 ). Transcriptional coactivation of bonespecific transcription factor Cbfa1 by TAZ . Mol...

... kinases in the yeast genome, we newly identified a regulator of autophagy, the Ccl1–Kin28 kinase complex (the equivalent of the mammalian cyclin-H–Cdk7 complex), which is known to play key roles in RNA-polymerase-II-mediated transcription. We show that inactivation of Ccl1 caused complete block...

..., the mechanisms by which anterograde and retrograde movement are coordinated with one another and with stationary axonal mitochondria are not yet understood. In this Commentary, we review why mitochondria move and how they move, focusing particularly on recent studies of transport regulation, which implicate...

...., Zwerger, K., Meskiene, I., Binarova, P., Csizmadia, V., Planck, C., Wagner, E., Hirt, H. and Heberle-Bors, E. ( 1997 ). The cdc2Ms kinase is differently regulated in the cytoplasm and in the nucleus. Plant Physiol. 113 , 841 -852. Bögre, L., Calderini, O., Binarova, P., Mattauch, M., Till, S...

...Zohra Rahmani The Src nonreceptor tyrosine kinase plays an important role in multiple signalling pathways that regulate several cellular functions including proliferation, differentiation and transformation. The activity of Src is tightly regulated in vivo and can be modulated by interactions...

... to a working concentration of 5 μM. To investigate how SAC-induced calcium transients regulate the generation of traction force in relation to cell movement, we have correlated calcium-induced changes in traction stress with measures of cell speed and shape during one cycle of mechano-chemical...

...Sourav Ghosh; Frank C. Dorsey; John V. Cox Previous analyses have shown that the phosphorylation state of chicken erythroid ankyrin regulates its association with the spectrin cytoskeleton in vivo. Treatment of erythroid cells with serine and threonine phosphatase inhibitors stimulates...

... association for all three isoforms, indicating a negative regulatory role for the unique tail regions. We have tested this hypothesis by constructing a series of deletion and substitution mutants for all three CaP isoforms. Here we demonstrate that the C-terminal sequences regulate actin association...

... for correspondence (e-mail: mozawa@m.kufm.kagoshima-u.ac.jp ) 27 11 2000 © 2001 by Company of Biologists 2001 Cadherin Catenin p120 Phosphorylation Regulation A family of transmembrane glycoproteins called cadherins plays essential roles in the initiation and stabilization of cell...

... to the bristle cytoplasm as well as playing a role in vesicle transport. * Author for correspondence (e-mail: gguild@sas.upenn.edu ) 07 03 2000 21 01 2000 © 2000 by Company of Biologists 2000 Actin Drosophila Bristle Bundle assembly Regulation We are interested...

...Virginie Bender; Sylvie Büschlen; Doris Cassio ABSTRACT We have studied two aspects of the plasma membrane of hepatocytes, highly differentiated epithelial cells that exhibit a particular and complex polarity. Using a genetic approach, we have distinguished between the expression/regulation...

...A. Paul Mould © 1992 by Company of Biologists 1992 Integrin Regulation Conformational state Allostery Integrins are a large family of cell-adhesion receptors, with a conserved αβ heterodimeric structure ( Hynes, 1992 ). They play crucial roles in normal physiological processes...

...-specific and developmentally regulated gene . J. Cell Biol . 123 , 823 – 835 . Dix , D. J. and Eisenberg , B. R. ( 1991 ). Redistribution of myosin heavy chain mRNA in the midregion of stretched muscle fibers . Cell Tiss. Res . 263 , 367 – 375 . Flink , I. L...

.... Mutational studies have shown that E1A’s oncogenic ability is determined primarily by its ability to bind to certain cellular proteins and interfere with their function. One of these cellular targets for E1A is the product of the retinoblastoma tumor suppressor gene, pRB. pRB is a negative regulator of cell...

.... * Author for correspondence 28 05 1993 10 09 1993 © 1993 by Company of Biologists 1993 transcytosis regulation peroxidase-polylysine conjugate It has been demonstrated extensively that epithelial cells develop a distinct membrane polarity whether they exist in vivo...

... 06 1993 © 1993 by Company of Biologists 1993 myosin heavy chain in situ hybridization genes regulation Muscle growth in agricultural animals, such as the pig, is of major scientific and commercial interest. However, the methods employed in the manipulation of growth...

... proteins can penetrate across both mitochondrial membranes and how some of these proteins can regulate the expression of specific mitochondrial genes. y. Cell Set. Suppl. ¡1, 1-11 (1989) Printed in Great Britain © The Company of Biologists Limited 1989 1 Interaction between mitochondria and the nucleus L...