...+DHA co-treatment on the exocytosis of SLVs in response to 100 mM KCl in ER-stressed cells. Although there was a subtle restoration of impaired regulated secretion of SLVs in Tg+DHA-co-treated ER-stressed cells, the magnitude of restoration was not on the order of DCV exocytosis ( Fig. 6A–C ; Movies 5...

..., these inhibitors eliminated regulated secretion and blocked prohormone processing. Drug treatment caused the formation of large, mixed organelles, with components of immature granules and lysosomes and some markers of autophagy. Markers of the trans -Golgi network and earlier secretory pathway were unaffected...

... Zürich, Switzerland 23 4 2009 © The Company of Biologists Limited 2009 2009 Giardia Golgi Regulated secretion Membrane transport GTPase Arf1 Sar1 Cyst wall Membrane tubule Giardia lamblia ( Adam, 2001 ), an intestinal parasite with worldwide distribution...

... levels in primary rat pancreatic β-cells using a recombinant adenovirus, in order to study the importance of clathrin for proinsulin trafficking and processing, as well as the regulated secretion of proinsulin and its conversion products, insulin and C-peptide. Although the precise role of clathrin...

... © 1999 by Company of Biologists 1999 Regulated secretion AP-1 Clathrin-coated vesicle Furin Casein kinase II The molecular details of secretory granule formation from trans-Golgi network (TGN) membranes is the subject of controversy and the precise mechanisms involved...

... for correspondence (e-mail: [email protected] ) 15 05 1996 22 07 1996 © 1996 by Company of Biologists 1996 Regulated secretion Acinar cell Salivary protein Cells that are specialized for regulated secretion store most of their secretory proteins in membrane-bounded granules...

... not been possible to evaluate the role of this polypeptide segment as a sorting signal for regulated secretion. We now show that addition of the six-amino acid propeptide of proparathyroid hormone to the proline-rich protein, and especially to a deletion mutant lacking the N-terminal domain, dramatically...

.... To investigate whether Ca 2+ /calmodulin kinase II plays a role in the regulated secretion of catecholamines, we examined the effect of the specific Ca 2+ /calmodulin kinase II inhibitor KN-62 on the carbachol-induced release of norepinephrine from PC12 cells. Approximately 50% of the regulated release...

... exocrine, endocrine and hemopoietic cell types. * Author for correspondence 28 06 1993 31 01 1994 © 1994 by Company of Biologists 1994 GRL antigen regulated secretion secretory granule membrane From yeast to mammals, all types of cells secrete proteins...