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Keywords: Regulated secretion
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Journal Articles
Journal Articles
J Cell Sci (2009) 122 (19): 3542–3553.
Published: 1 October 2009
..., these inhibitors eliminated regulated secretion and blocked prohormone processing. Drug treatment caused the formation of large, mixed organelles, with components of immature granules and lysosomes and some markers of autophagy. Markers of the trans -Golgi network and earlier secretory pathway were unaffected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2846–2856.
Published: 15 August 2009
... Zürich, Switzerland 23 4 2009 © The Company of Biologists Limited 2009 2009 Giardia Golgi Regulated secretion Membrane transport GTPase Arf1 Sar1 Cyst wall Membrane tubule Giardia lamblia ( Adam, 2001 ), an intestinal parasite with worldwide distribution...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (16): 3059–3066.
Published: 15 August 2001
... incubated for a further 60 minutes of chase in presence of a cocktail of secretagogues in order to stimulate (regulated) secretion of products stored in secretory granules. At the end of the second chase incubation, cells were extracted. Both the chase media and cell extracts were analyzed by reverse-phase...
Journal Articles
J Cell Sci (1999) 112 (22): 3955–3966.
Published: 15 November 1999
... © 1999 by Company of Biologists 1999 Regulated secretion AP-1 Clathrin-coated vesicle Furin Casein kinase II The molecular details of secretory granule formation from trans-Golgi network (TGN) membranes is the subject of controversy and the precise mechanisms involved...
Journal Articles
J Cell Sci (1996) 109 (10): 2591–2599.
Published: 1 October 1996
.... 15 05 1996 22 07 1996 © 1996 by Company of Biologists 1996 Regulated secretion Acinar cell Salivary protein Fig. 1. (a,b) Fluorographs illustrating the timecourse of output of secretory proteins during successive 40 minute intervals of chase incubation following pulse...
Journal Articles
J Cell Sci (1996) 109 (6): 1637–1645.
Published: 1 June 1996
... not been possible to evaluate the role of this polypeptide segment as a sorting signal for regulated secretion. We now show that addition of the six-amino acid propeptide of proparathyroid hormone to the proline-rich protein, and especially to a deletion mutant lacking the N-terminal domain, dramatically...
Journal Articles
J Cell Sci (1995) 108 (7): 2619–2628.
Published: 1 July 1995
.... To investigate whether Ca 2+ /calmodulin kinase II plays a role in the regulated secretion of catecholamines, we examined the effect of the specific Ca 2+ /calmodulin kinase II inhibitor KN-62 on the carbachol-induced release of norepinephrine from PC12 cells. Approximately 50% of the regulated release...
Journal Articles
J Cell Sci (1994) 107 (5): 1297–1308.
Published: 1 May 1994
... exocrine, endocrine and hemopoietic cell types. * Author for correspondence 28 06 1993 31 01 1994 © 1994 by Company of Biologists 1994 GRL antigen regulated secretion secretory granule membrane From yeast to mammals, all types of cells secrete proteins...