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Keywords: Recombination
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Journal Articles
J Cell Sci (2024) 137 (7): jcs261912.
Published: 12 April 2024
..., often in the form of repetitive DNA; (2) recombination initiation during meiosis; and (3) physical proximity of the homologous sequences in three-dimensional space. This Hypothesis highlights the latest progress in understanding human Robertsonian translocations within the context of the broader...
Journal Articles
J Cell Sci (2020) 133 (15): jcs243667.
Published: 12 August 2020
...Adél Sepsi; Trude Schwarzacher ABSTRACT During prophase I of meiosis, homologous chromosomes pair, synapse and exchange their genetic material through reciprocal homologous recombination, a phenomenon essential for faithful chromosome segregation. Partial sequence identity between non-homologous...
Journal Articles
J Cell Sci (2015) 128 (9): 1800–1811.
Published: 1 May 2015
... the initiation of meiotic recombination. Meiotic DSB formation is catalyzed by SPO11 and their repair takes place on meiotic chromosome axes. The evolutionarily conserved MEI4 protein is required for meiotic DSB formation and is localized on chromosome axes. Here, we show that HORMAD1, one of the meiotic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1494–1506.
Published: 15 April 2015
... proteins. Thus, the 9‐1‐1 complex functions to promote two crucial meiotic recombination processes, the regulation of interhomolog recombination and crossover formation mediated by ZMM. To elucidate the role of Rad51‐dependent interhomolog bias in ZMM assembly, we analyzed Zip3 focus formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4658–4666.
Published: 1 November 2014
... on crossover distribution, suggesting that Yem has an early role in meiotic recombination. This is further supported by the impact of yem mutations on DSB kinetics. A Hira mutation gave a similar effect, presumably through disruption of Hira–Yem complex. We then chose to score recombination frequency...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3095–3104.
Published: 15 July 2013
... to the first meiotic division, homologous recombination (HR) repairs Spo11-dependent DNA double-strand breaks (DSBs) in the presence of telomere movements to allow for chromosome pairing and segregation at the meiosis I division. In contrast to HR, non-homologous end joining (NHEJ), the major DSB repair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5873–5880.
Published: 1 December 2012
... that is triggered by meiotic DNA double-strand breaks (DSBs), suggesting that the bouquet is needed for DSB repair. However, in the present study we show that although homologous pairing is impeded in the absence of the bouquet, DSB repair takes place nevertheless. Moreover, recombinational DSB repair, as monitored...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2753–2764.
Published: 1 June 2012
... is unknown and the subject of this study. We show that brc1 Δ cells are significantly delayed in recovery from replication pausing, though this does not activate a DNA damage checkpoint. DNA repair and recombination protein Rad52 is a homologous recombination protein that loads the Rad51 recombinase...
Journal Articles
J Cell Sci (2011) 124 (16): 2687–2691.
Published: 15 August 2011
.... , West S. C. ( 2008 ). Structural and functional relationships of the XPF/MUS81 family of proteins . Annu. Rev. Biochem. 77 , 259 - 287 . Cromie G. A. , Smith G. R. ( 2007 ). Branching out: meiotic recombination and its regulation . Trends Cell Biol. 17 , 448 - 455...
Journal Articles
J Cell Sci (2011) 124 (14): 2488–2500.
Published: 15 July 2011
...Esther Refolio; Santiago Cavero; Edyta Marcon; Raimundo Freire; Pedro A. San-Segundo During meiosis, accurate segregation of intact chromosomes is essential for generating healthy gametes. Defects in recombination and/or chromosome synapsis activate the pachytene checkpoint, which delays meiotic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 1955–1963.
Published: 15 June 2011
... revealed that both pairing and synapsis in the recombinationally suppressed regions still occurred at normal frequencies ( Sherizen et al., 2005 ). Normal levels of pairing and synapsis were also observed in females that were heterozygous for a normal sequence X chromosome and a multiply rearranged...
Journal Articles
J Cell Sci (2009) 122 (22): 4013–4025.
Published: 15 November 2009
... Shelterin ALT Aging Recombination Genome stability Telomeres consist of a repetitive non-coding sequence that terminates in a single-stranded overhang at the end of linear chromosomes in eukaryotes and some prokaryotes. Both the overhang and the upstream double-stranded region serve as binding...
Journal Articles
J Cell Sci (2008) 121 (13): 2148–2158.
Published: 1 July 2008
...Kazufumi Mochizuki; Maria Novatchkova; Josef Loidl During meiosis, the micronuclei of the ciliated protist Tetrahymena thermophila elongate dramatically. Within these elongated nuclei, chromosomes are arranged in a bouquet-like fashion and homologous pairing and recombination takes place. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3123–3137.
Published: 1 September 2007
...Radhika S. Khetani; Sharon E. Bickel During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila , null mutations in the ord gene abolish meiotic...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (13): 2957–2963.
Published: 1 July 2005
...Adela Calvente; Alberto Viera; Jesús Page; M. Teresa Parra; Rocío Gómez; José A. Suja; Julio S. Rufas; Juan L. Santos The relationship between meiotic recombination events and different patterns of pairing and synapsis has been analysed in prophase I spermatocytes of the grasshopper Stethophyma...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (12): 2755–2762.
Published: 15 June 2005
... and CESC1 in synaptonemal-complex assembly, and perhaps also stability and recombination. ‡ Author for correspondence (e-mail: howard.cooke@hgu.mrc.ac.uk ) * Present address: Neural Plasticity Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK 23 3 2005 ©...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (24): 5791–5801.
Published: 15 November 2004
...Josef Loidl; Harry Scherthan During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect...
Journal Articles
J Cell Sci (2004) 117 (15): 3343–3351.
Published: 1 July 2004
... presenting homologous DNA regions for homology recognition and recombination and/or the prevention of recombination between sisters. For this purpose, they need not be organized into canonical tripartite SCs or extend all along the chromosomes. If LEs have this function then one would expect them...