... a number of receptor tyrosine kinases, including EGFR, and select signaling molecules (Kurrle et al., 2012 ; Meister and Tikkanen, 2014 ; Staubach and Hanisch, 2011). Initial EGFR signaling occurs upon ligand binding at the plasma membrane. The plasma membrane contains several distinct types...

...Majd M. Ariss; Alexander R. Terry; Abul B. M. M. K. Islam; Nissim Hay; Maxim V. Frolov ABSTRACT The receptor tyrosine kinase (RTK) pathway plays an essential role in development and disease by controlling cell proliferation and differentiation. Here, we profile the Drosophila larval brain by single...

... of parasitized DCs. We report that signaling through the receptor tyrosine kinase Met (also known as HGF receptor) contributes to T. gondii -induced DC hypermotility. Furthermore, voltage-gated Ca 2+ channel (VGCC, subtype Ca V 1.3) signaling impacted the migratory activation of DCs via calmodulin–calmodulin...

...Linyu Zhu; Xiahui Xiong; Yongsoon Kim; Naomi Okada; Fei Lu; Hui Zhang; Hong Sun ABSTRACT Receptor tyrosine kinases (RTKs) are embedded in the lipid bilayer of the plasma membrane, but the specific roles of various lipids in cell signaling remain largely uncharacterized. We have previously found...

...Julhash U. Kazi; Shruti Agarwal; Jianmin Sun; Enrico Bracco; Lars Rönnstrand ABSTRACT The Src-like-adaptor protein (SLAP) is an adaptor protein sharing considerable structural homology with Src. SLAP is expressed in a variety of cells and regulates receptor tyrosine kinase signaling by direct...

... point for the discovery of the immediate downstream signaling events. * Author for correspondence ([email protected]) 1 2 2011 © 2011. 2011 Receptor tyrosine kinase CSF-1R PI3K Macrophage motility Colony stimulating factor-1 (CSF-1) is the primary growth factor...

.... Citri, A., Alroy, I., Lavi, S., Rubin, C., Xu, W., Grammatikakis, N., Patterson, C., Neckers, L., Fry, D. W. and Yarden, Y. (2002). Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. EMBO J. 21 , 2407 -2417. Citri, A., Kochupurakkal...

...Kei-ichi Ozaki; Satsuki Miyazaki; Susumu Tanimura; Michiaki Kohno Strict regulation of the receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) pathway is essential for maintaining balanced growth in multi-cellular organisms. Several negative regulators of the pathway have...

...Christoph Biskup; Annette Böhmer; Rico Pusch; Laimonas Kelbauskas; Alexander Gorshokov; Irina Majoul; Jörg Lindenau; Klaus Benndorf; Frank-D. Böhmer Signaling of receptor tyrosine kinases (RTKs) is regulated by protein-tyrosine phosphatases (PTPs). We previously discovered the efficient...

... stimulation of fibroblast growth factor receptors (FGFRs). Current evidence indicates that Cbl is a key protein that interacts directly with Spry2 following activation of receptor tyrosine kinases (RTKs). It appears to be the ability of Cbl to interact as an E3 ubiquitin ligase on specific target proteins...

...Keith K. Murai; Elena B. Pasquale The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in a wide variety of cell types in developing and mature tissues. Their ligands are the ephrins, a family of membrane-bound proteins found in lipid rafts. In the past decade...

... differing effects on the activity of the receptor tyrosine kinase encoded by RET . The normal function of the RET receptor tyrosine kinase has yet to be determined. However, this has been investigated by the inactivation of the RET gene in transgenic mice. The devel-opmental abnormalities apparent...