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Keywords: Receptor
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Journal Articles
J Cell Sci (2020) 133 (5): jcs236802.
Published: 05 December 2019
... in the communication between immune cells. It delivers its signal through different modes involving three receptor chains: IL-15Rα, IL-2Rβ and IL-2Rγc. The combination of the different chains result in the formation of IL-15Rα/IL-2Rβ/γc trimeric or IL-2Rβ/γc dimeric receptors. In this study, we have investigated...
Journal Articles
J Cell Sci (2015) 128 (13): 2213–2219.
Published: 01 July 2015
... complexes that crosslink glycosylated ligands to form a dynamic lattice. The galectin lattice regulates the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. The galectin lattice also regulates the selection, activation and arrest of T cells, receptor kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4279–4291.
Published: 01 October 2014
... into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages unique functions associated with specialized macromolecules for its cellular import (transferrin receptors) or export (ferroportin, also known as SLC40A1). Previous studies have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3109–3119.
Published: 01 October 2008
... transcription. These advances set the stage for future mechanistic studies investigating ligand-dependent activation of Notch receptors, and serve as a foundation for the development of mechanism-based inhibitors of signaling in the treatment of cancer and other diseases. Table 1. Structures of Notch...
Journal Articles
J Cell Sci (2007) 120 (17): 3053–3063.
Published: 01 September 2007
... cells require αvβ5 integrin receptors for particle binding that triggers engulfment. Here, we show that tetraspanins CD81 and CD9 reside in a complex specifically with αvβ5 integrin but not the engulfment receptors Mer tyrosine kinase and CD36 at the apical, phagocytic surface of RPE cells. Function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (6): 1309–1320.
Published: 15 March 2005
...Dennis Van Hoof; Kees W. Rodenburg; Dick J. Van der Horst The insect low-density lipoprotein (LDL) receptor (LDLR) homologue LpR mediates endocytosis of an insect lipoprotein (lipophorin) that is structurally related to LDL. Despite these similarities, lipophorin and LDL follow distinct...
Journal Articles
J Cell Sci (2003) 116 (18): 3803–3810.
Published: 15 September 2003
... mutant angiomotin failed to migrate and form tubes in an in vitro tube formation assay. To study the effect of angiomotin on embryonic angiogenesis, we generated transgenic mice expressing wild-type angiomotin and the C-terminal deletion mutant driven by the endothelial cell-specific receptor tyrosine...
Journal Articles
J Cell Sci (2003) 116 (16): 3269–3276.
Published: 15 August 2003
... matrix assembly is a cell-mediated process in which soluble dimeric FN is converted into a fibrillar network. Binding of cell surface integrin receptors to FN converts it to an active form, which promotes fibril formation through interactions with other cell-associated FN dimers. As FN fibrils form...
Journal Articles
J Cell Sci (2003) 116 (15): 3213–3219.
Published: 01 August 2003
... proteins can be recruited to clusters, we appended the PSD-95 binding consensus (-SDV) from the C-terminus of NMDA receptor 2B (NR2B) to the short cytoplasmic tail of the interleukin-2 receptor α-subunit (IL-2 or Tac), a well-characterized plasma membrane protein. When expressed with PSD-95 in COS7 cells...
Journal Articles
J Cell Sci (2002) 115 (6): 1107–1112.
Published: 15 March 2002
...Junhyong Kim; John R. Carlson A new algorithm that examines DNA databases for proteins that have a particular structure, as opposed to a particular sequence, represents a novel`e-genetics' approach to gene discovery. The algorithm has successfully identified new G-protein-coupled receptors, which...
Journal Articles
J Cell Sci (2002) 115 (1): 165–173.
Published: 01 January 2002
...Stéphane Martin; Jean-Pierre Vincent; Jean Mazella Receptor recycling plays a key role in the modulation of cellular responses to extracellular signals. The purpose of this work was to identify residues in G-protein coupled neurotensin receptors that are directly involved in recycling. Both...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_11): 179–186.
Published: 01 January 1989
.... The loss is also inhibited by pretreating the membranes with apyrase at 37 °C, which suggests that nucleotide triphosphates are required. Introduction The low density lipoprotein (LDL) receptor is one of many receptors that utilize clathrin-coated pits to carry their ligand into the cell (Goldstein et al...