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Keywords: Reactive oxygen species
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Journal Articles
J Cell Sci (2021) 134 (6): jcs253203.
Published: 26 March 2021
...) phenotype, increased levels of reactive oxygen species (ROS), γ-H2AX and a senescence-associated gene expression signature, and has three stages of senescence –initiation, pseudo-senescence and permanent senescence. Ciprofloxacin withdrawal during initiation and pseudo-senescence reinitiated proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs239277.
Published: 09 April 2020
... that AKT-expressing cells dying in galactose also upregulated nonsense-mediated mRNA decay, a marker of sensitivity to oxidative stress. We therefore measured levels of reactive oxygen species (ROS) and discovered that galactose-induced ROS exclusively in cells expressing AKT. Furthermore, ROS were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs226258.
Published: 26 April 2019
...-derived reactive oxygen species and the attenuation of reversible cytosolic translation through the oxidation of ribosomal proteins at their cysteine residues. We also discuss emerging concepts of how cellular mechanisms to stress are adapted, including the existence of alternative ribosomes and stress...
Journal Articles
J Cell Sci (2017) 130 (15): 2631–2643.
Published: 01 August 2017
...Hiroyuki Sasakura; Hiroki Moribe; Masahiko Nakano; Kazuto Ikemoto; Kosei Takeuchi; Ikue Mori ABSTRACT Reactive oxygen species (ROS), originally characterized based on their harmful effects on cells or organisms, are now recognized as important signal molecules regulating various biological...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (15): 2620–2630.
Published: 01 August 2017
... of PHBs increases mitoflash frequency by up to 5.4-fold due to elevated basal reactive oxygen species (ROS) production in the mitochondria. Mechanistically, PHB deficiency impairs the formation of mitochondrial respiratory supercomplexes (RSCs) without altering the abundance of individual respiratory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1413–1420.
Published: 15 April 2017
... induced by DNA damage. Furthermore, ectopic expression of wild-type PRODH, but not enzymatically inactive forms, induced senescence associated with the increase in reactive oxygen species (ROS) and the accumulation of DNA damage. Treatment with N-acetyl-L-cysteine, a ROS scavenger, prevented senescence...
Journal Articles
J Cell Sci (2017) 130 (8): 1486–1493.
Published: 15 April 2017
... is unavailable. We now analyze CME in astrocytes that have been cultured from CerS2 null mice, and show that they contain elevated levels of reactive oxygen species (ROS), which trigger a reduction in the transcription of Hsc70 (also known as HSPA8) – a protein involved in uncoating clathrin vesicles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (7): 1285–1298.
Published: 01 April 2017
...Ilse Dingjan; Peter T. A. Linders; Luuk van den Bekerom; Maksim V. Baranov; Partho Halder; Martin ter Beest; Geert van den Bogaart ABSTRACT In dendritic cells, the NADPH oxidase 2 complex (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 975–988.
Published: 01 March 2017
.... ( 2010 ). Reactive oxygen species in cancer . Free Radic. Res.   44 , 479 - 496 . 10.3109/10715761003667554 Lisse , T. S. , King , B. L. and Rieger , S. ( 2016 ). Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 190–202.
Published: 01 January 2017
...Linzhang Li; Jie Chen; Gaofeng Xiong; Daret K. St Clair; Wei Xu; Ren Xu; Andrew Ewald ABSTRACT Loss of epithelial cell polarity promotes cell invasion and cancer dissemination. Therefore, identification of factors that disrupt polarized acinar formation is crucial. Reactive oxygen species (ROS...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2015) 128 (21): 3849–3860.
Published: 01 November 2015
...Marija Vlaski-Lafarge; Zoran Ivanovic ABSTRACT Many studies have provided evidence for the crucial role of the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the regulation of differentiation and/or self-renewal, and the balance between quiescence and proliferation...
Journal Articles
J Cell Sci (2015) 128 (2): 342–353.
Published: 15 January 2015
...Raji R. Nair; Meisam Bagheri; Deepak Kumar Saini ABSTRACT Cells exposed to genotoxic stress induce cellular senescence through a DNA damage response (DDR) pathway regulated by ATM kinase and reactive oxygen species (ROS). Here, we show that the regulatory roles for ATM kinase and ROS differ during...
Journal Articles
J Cell Sci (2014) 127 (19): 4234–4245.
Published: 01 October 2014
... caused by reactive oxygen species (ROS), and that this phosphorylated MRS shows increased affinity for non-cognate tRNAs with lower affinity for tRNA Met , leading to an increase in Met residues in cellular proteins. The expression of a mutant MRS containing the substitutions S209D and S825D, mimicking...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3649–3658.
Published: 01 September 2014
... of dedicated protein disulfide isomerases with ER stress sensors, protein S-nitrosylation and ER Ca 2+ efflux that is promoted by reactive oxygen species. Furthermore, we discuss how cellular oxidant and antioxidant capacities are extensively remodeled downstream of UPR signals. Aside from activation of NADPH...
Journal Articles
J Cell Sci (2014) 127 (8): 1621–1629.
Published: 15 April 2014
... of reactive oxygen species (ROS). There are two CALI approaches that use either transgenic tags with chemical photosensitizers, or genetically encoded fluorescent protein fusions. Using spatially restricted microscopy illumination, CALI can address questions regarding, for example, protein isoforms...
Journal Articles
J Cell Sci (2013) 126 (14): 2965–2978.
Published: 15 July 2013
... membranes MAM Ryanodine receptor Uniporter Ca 2+ signalling reactive oxygen species ROS Isolated mitochondria are competent to produce energy on their own and are not particularly responsive to changes in their environment that mimic intracellular signals. These observations supported...
Journal Articles
J Cell Sci (2012) 125 (4): 956–964.
Published: 15 February 2012
... that it promotes angiogenic responses in endothelial cells, although the underlying signalling mechanisms are unclear. Reactive oxygen species derived from NADPH oxidases are major signalling molecules in the vasculature. Because NOX2 is functional in endothelial cells, we investigated the role of the NOX2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (3): 614–624.
Published: 01 February 2012
... of their function, and information comes almost exclusively from neural cells. In this study we show that in non-neural cells human MICALs are required for normal actin organization, and all three MICALs regulate actin stress fibers. Moreover, we provide evidence that the generation of reactive oxygen species...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 1973–1983.
Published: 15 June 2011
...-stimulated production of reactive oxygen species (ROS) in neutrophils. Significantly we found that this role of PLD is isoform specific: the absence of PLD2 does not negatively affect these processes. Contrary to expectation, other functions required for an efficient immune response operate effectively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 847–855.
Published: 15 March 2011
... formation Glutathione Ero1 Reactive oxygen species Apoptosis Glutathione is an ubiquitous low molecular weight compound synthesized in the cytosol. It consists of the three amino acids glutamate, cysteine and glycine that are linearly linked by a γ-peptide and a conventional α-peptide bond...