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Keywords: Rap1
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Journal Articles
J Cell Sci (2019) 132 (21): jcs235531.
Published: 01 November 2019
...Thomas Bromberger; Liang Zhu; Sarah Klapproth; Jun Qin; Markus Moser ABSTRACT Recruitment and tethering of talin to the plasma membrane initiate the process of integrin activation. Multiple factors including the Rap1 proteins, RIAM (also known as APBB1IP) and PIP 2 bind talin proteins and have been...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2018) 131 (24): jcs225144.
Published: 18 December 2018
... recruitment to, and maintenance at, sites of integrin-mediated adhesion requires a direct interaction between Talin and the GTPase Rap1. A mutation that blocks the direct binding of Talin to Rap1 abolished Talin recruitment to sites of adhesion and the resulting phenotype phenocopies that seen with null...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs207779.
Published: 26 March 2018
... to assemble into sheets. Here, we show that the small GTPase Rap1, its effector Canoe (Cno) and the Cdc42 effector kinase Mushroom bodies tiny (Mbt), converge in regulating epithelial morphogenesis by coupling stabilization of the adherens junction (AJ) protein E-Cadherin and Bazooka retention at the ZA...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (6): 1094–1109.
Published: 15 March 2017
... cell receptor (BCR), signal transduction and antigen internalization. Immune synapse formation involves polarization of the microtubule-organizing center (MTOC) towards the APC. We now show that BCR-induced MTOC polarization requires the Rap1 GTPase (which has two isoforms, Rap1a and Rap1b...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4341–4352.
Published: 01 December 2015
..., with a key component of inside-out signaling, namely the active form of the small GTPase Rap1 (which has two isoforms, Rap1A and Rap1B). This interaction has been further shown to facilitate the interdependent recruitment of Rap1 and SLAT to the T cell immunological synapse upon TCR engagement. Furthermore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2302–2313.
Published: 15 June 2015
... prolonged agonist treatment; however, the underlying mechanisms are unclear. Here, we identify the small GTPase Rap1 as a key regulator for promoting GABA B receptor surface expression. Agonist stimulation of GABA B receptor signals through Gαi/o to inhibit Rap1GAPII (also known as Rap1GAP1b, an isoform...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3095–3104.
Published: 15 July 2013
... mechanism during the G1 cell cycle phase, is downregulated during early meiotic prophase. At somatic mammalian telomeres, the NHEJ factor Ku70/80 inhibits HR, as does the Rap1 component of the shelterin complex. Here, we investigated the role of Ku70 and Rap1 in meiotic telomere redistribution and genome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2153–2164.
Published: 01 July 2011
..., leading edge attachment and persistent migration during chemotaxis. This pathway depends upon G i -protein-mediated activation and leading edge recruitment of Lyn, a non-receptor tyrosine kinase belonging to the Src kinase family. We identified the small GTPase Rap1 as a major downstream effector of Lyn...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1808–1818.
Published: 01 June 2011
...-signal transduction, we performed a small-scale siRNA screen in A549 lung epithelial cells. Of the Rap effectors tested, only Radil blocked Rap-induced spreading. Additionally, we identified a novel role for Ezrin downstream of Rap1. Ezrin was necessary for Rap-induced cell spreading, but not Rap-induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2996–3004.
Published: 15 August 2009
... spread again after cytokinesis. Because of the well-documented ability of the small GTPase Rap1 to stimulate integrin-dependent adhesion and spreading, we assessed its role during mitosis. We show that Rap1 activity is regulated during this process. Changes in Rap1 activity play an essential role...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 335–344.
Published: 01 February 2009
... that control these processes. One candidate is Rap1, as it has been implicated in the regulation of adhesion and motility in cell culture. To further study the role of Rap1 during multicellular development, we generated a mutant in a potential Rap1 GTPase activating protein (RapGAPB) in Dictyostelium . rapGAPB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (1): 17–22.
Published: 01 January 2007
...Matthijs R. H. Kooistra; Nadia Dubé; Johannes L. Bos Rap1 is a Ras-like small GTPase that is activated by many extracellular stimuli and strongly implicated in the control of integrin-mediated cell adhesion. Recent evidence indicates that Rap1 also plays a key role in formation of cadherin-based...
Journal Articles
J Cell Sci (2006) 119 (15): 3067–3077.
Published: 01 August 2006
... activation of the small G protein Rap1 and that expression of a dominant active Rap1 mutant restored neurite outgrowth in Dok-4-depleted cells. By contrast, expression of a dominant negative Rap1 mutant impaired GDNF-stimulated neurite outgrowth from TGW cells. Finally, we found that neurite formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (25): 6085–6094.
Published: 01 December 2004
... of the small G protein Rap1 by both cAMP and NGF. In these cells, Rap1 is required for cAMP/PKA signaling to ERKs and also for the sustained activation of ERKs by NGF. The activation of Rap1 by both cAMP and NGF was blocked by PP2, an inhibitor of Src family kinases, and by a Src mutant incapable of being...
Journal Articles
J Cell Sci (2003) 116 (3): 435–440.
Published: 01 February 2003
...Emmanuelle Caron Rap1 belongs to the Ras subgroup of small GTP-binding proteins. Whereas its early history has focused on its biochemical homology to Ras and the alleged functional antagonism between these two small GTPases, recent cellular evidence suggests that endogenous Rap1 plays a unique, Ras...
Journal Articles
J Cell Sci (2002) 115 (24): 4915–4924.
Published: 15 December 2002
.../HEF1 association domain also shows sequence similarity with guanine nucleotide exchange factors for Ras family small GTPases. In this study, we found significant activation of Rap1 in Chat-overexpressing cells. Myr-Chat, a membrane-targeted form of Chat,activated Rap1 more efficiently. Interestingly...