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Keywords: Rafts
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Journal Articles
J Cell Sci (2017) 130 (18): 3050–3059.
Published: 15 September 2017
... concentrations, translocation of cytoplasmic phospholipase A 2 (cPLA 2 , also known as PLA2G4A) to lipid rafts, and activation of cPLA 2 . The formation of Aβ-PrP C complexes is controlled by the cholesterol ester cycle. In this study, Aβ activated cholesterol ester hydrolases, which released cholesterol from...
Journal Articles
J Cell Sci (2017) 130 (16): 2682–2695.
Published: 15 August 2017
...Ji Hyun Kim; Ashutosh Singh; Maurizio Del Poeta; Deborah A. Brown; Erwin London ABSTRACT Ordered lipid domains (rafts) in plasma membranes have been hypothesized to participate in endocytosis based on inhibition of endocytosis by removal or sequestration of cholesterol. To more carefully...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3409–3416.
Published: 01 August 2013
...Romain Galmes; Jean-Louis Delaunay; Michèle Maurice; Tounsia Aït-Slimane Summary Targeting of glycosyl-phosphatidylinositol (GPI)-anchored proteins (GPI-APs) in polarized epithelial cells depends on their association with detergent-resistant membrane microdomains called rafts. In MDCK cells, GPI...
Journal Articles
J Cell Sci (2012) 125 (4): 869–886.
Published: 15 February 2012
...) in the plasma membrane. Biochemical data suggest that ACs reside in membrane rafts and could compartmentalize intermediary scaffolding proteins and associated regulatory elements. However, little is known about the organization or regulation of the dynamic behaviour of ACs in a cellular context. The present...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4001–4007.
Published: 15 December 2008
... rafts or the association of the two different GPI-APs to different lipid rafts, which in turn influences the oligomerisation state of the protein and, therefore, its sorting behaviour. To test these hypotheses we decided to alter the amount of cholesterol in the MDCK cell membrane, because it appears...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 395–406.
Published: 01 February 2007
...Carolin Neumann-Giesen; Inga Fernow; Monia Amaddii; Ritva Tikkanen Cholesterol and sphingolipid-rich membrane microdomains or rafts have been shown to be involved in signaling through many growth factor receptors but the molecular details of these processes are not well understood. The reggie...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2688–2694.
Published: 01 July 2006
...Tatiana Rogasevskaia; Jens R. Coorssen Membrane microdomains or `rafts' are suggested to act as regulators of the exocytotic process and also appear to be the sites of Ca 2+ -triggered membrane fusion. Microdomains are postulated to maintain the localization of `efficiency' factors, including Ca 2...
Journal Articles
J Cell Sci (2004) 117 (25): 5955–5964.
Published: 01 December 2004
..., which have been used as a model system for studies of sorting mechanisms. The clustering of lipid rafts through the oligomerization of raft components could be utilized for segregating apical from basolateral cargo and for the generation of intracellular transport carriers. Besides functioning...
Journal Articles
J Cell Sci (2004) 117 (22): 5269–5282.
Published: 15 October 2004
... dynamics. Here, we have studied the relationships between tetraspanins, cytoskeleton and raft microdomains, and their relevance in T-cell signaling. Localization studies and density-gradient flotation experiments indicate that part of tetraspanins localizes in raft microdomains linked to the actin...
Journal Articles
J Cell Sci (2004) 117 (15): 3095–3105.
Published: 01 July 2004
... of tissues expressing caveolin, SR-BI is localized in caveolae. We show using detergent-free sucrose gradients that SR-BI is found in membrane rafts devoid of caveolin-1 in the human hepatoma HepG2 cell. Perturbation of the structure of HepG2 cell membrane rafts with cholesterol oxidase or sphingomyelinase...
Journal Articles
J Cell Sci (2002) 115 (15): 3119–3130.
Published: 01 August 2002
... of the recombinant construct to low-fluidity domains in a myristate-palmitate distance-dependent manner. * Author for correspondence (e-mail: nacho@bbm1.ucm.es ) 17 5 2002 © The Company of Biologists Limited 2002 2002 Myristoylation Caveolin Palmitoylation Rafts Subcellular targeting...
Journal Articles
J Cell Sci (2002) 115 (6): 1331–1340.
Published: 15 March 2002
... that the EGFR is randomly distributed at the plasma membrane and not enriched in caveolae. Binding of EGF at 4°C does not change the localization of EGFR,and by immunoelectron microscopy we find that only small amounts of bound EGF localize to caveolae. However, upon patching of lipid rafts, we find...
Journal Articles
J Cell Sci (2002) 115 (4): 713–724.
Published: 15 February 2002
... content nor cholesterol metabolism changed in Vim -/- cells. Our results are consistent with the view that re-expression of vimentin in epithelial cells could be instrumental to maintain the physical state of rafts and, thus, the function of DRM-associated proteins. * Author for correspondence (e...
Journal Articles
J Cell Sci (2002) 115 (4): 827–838.
Published: 15 February 2002
... nucleotide-gated ion channels( Brown et al., 1999 ; Morrissette et al., 1995 ). Together with plant PR-1 proteins, these proteins constitute a large PR-1 protein superfamily. Accepted 5 November Golgi Microdomains Rafts Plant pathogenesis-related protein PR-1 Myristoylation Caveolin...