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Keywords: Raf
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Journal Articles
J Cell Sci (2016) 129 (7): 1287–1292.
Published: 1 April 2016
... HRAS-mediated RAF signaling ( Jura et al., 2006 ). NRAS was also shown to be similarly ubiquitylated, whereas KRAS has later shown to be mono/di- ubiquitylated ( Sasaki et al., 2011 ). Monoubiquitylation of KRAS4B at K147 increased effector binding, whereas ubiquitylation-deficient KRAS G12V showed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4553–4559.
Published: 15 October 2013
... the generation of a constitutively GTP-loaded, active form of K-Ras, phosphorylation at Ser181 within the C-terminal hypervariable region can modulate oncogenic K-Ras function without affecting the in vitro affinity for its effector Raf-1. In striking contrast, K-Ras phosphorylated at Ser181 shows increased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1812–1822.
Published: 1 June 2009
..., but not Fyn or Lyn, results in significant inhibition of EC lumen formation. Concurrent with Cdc42 activation, PKCϵ- and SFK-dependent signaling converge to activate p21-activated kinase (Pak)2 and Pak4 in steps that are also required for EC lumen formation. Pak2 and Pak4 further activate two Raf kinases, B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (6): 1061–1071.
Published: 15 March 2007
... to assemble the basal matrix. Hence, we propose that integrins control epithelial cell shape by mediating adherence of these cells to the ECM. Finally, we show that the ECM has an instructive rather than a structural role, because inhibition of Raf reverses the cell shape changes caused by perturbing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (14): 2879–2886.
Published: 15 June 2004
... Ras GTPase Raf Reporter Probe Biosensor Imaging Signalling Membrane Trafficking Plasma membrane Golgi Endoplasmic reticulum Endosomes Prenylation Palmitoylation Three human Ras proto-oncogenes encode small GTPases (HRas, N-Ras, K-Ras4A and K-Ras4B) that operate as binary...
Journal Articles
J Cell Sci (2002) 115 (8): 1575–1581.
Published: 15 April 2002
...Alison Hindley; Walter Kolch Raf comprises a family of three kinases, A-Raf, B-Raf and Raf-1, which are best known as key regulators of the MEK—MAPK/ERK cascade. This module is often perceived as a linear pathway in which ERK is the effector. However,recent advances have unveiled a role for Raf...