1-13 of 13
Keywords: Rad51
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2020) 133 (3): jcs233437.
Published: 12 February 2020
... reporter, irradiation-induced focus formation and colony formation assays, we show that USP9X is required for efficient HR. Mechanistically, we show USP9X is important to sustain the expression levels of key HR factors, namely BRCA1 and RAD51 through a non-canonical regulation of their mRNA abundance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (24): jcs226480.
Published: 17 December 2018
... and are known multicopy suppressors of swi6 Δ phenotypes, partially reverse swi6 Δ genome instability when overexpressed. Another gene on chromosome V, RAD51 , also supports swi6 Δ survival, but at a high cost; Rad51–dependent illegitimate recombination in swi6 Δ cells appears to connect DSBs, leading to genome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1097–1107.
Published: 15 March 2015
... variant H2Av ( Drosophila ) or H2AX (humans), but impairs the recruitment of the homologous recombination factor RAD51 to the damaged sites, without affecting RAD51 levels. The recruitment of RAD51 to DSBs in S2 cells is also inhibited by overexpression of RRP6-Y361A–V5, a catalytically inactive RRP6...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 317–330.
Published: 15 January 2015
... and enhances DSB repair. Using DR-GFP and EJ5-GFP reporter systems, we demonstrate that BRG1 facilitates homologous recombination repair rather than nonhomologous end-joining (NHEJ) repair. Moreover, the BRG1–RAD52 complex mediates the replacement of RPA with RAD51 on single-stranded DNA (ssDNA) to initiate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (22): 5284–5292.
Published: 15 November 2013
... and exogenous sources of DNA damage. DNA double-strand breaks (DSBs) are extremely dangerous DNA lesions. RAD51 plays a central role in homologous DSB repair, by facilitating the recombination of damaged DNA with intact DNA in eukaryotes. RAD51 accumulates at sites containing DNA damage to form nuclear foci...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (17): 3093–3103.
Published: 01 September 2009
...-recombinogenic function either by dissolution of double Holliday junctions or by disruption of RAD51 nucleofilaments. We have now found that BLM can interact with the pro-recombinogenic protein RAD54 through an internal ten-residue polypeptide stretch in the N-terminal region of the helicase. The N-terminal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (23): 4209–4220.
Published: 01 December 2007
... focus formation without affecting DSB processing, arguing for a direct involvement of RPA in Mec1-Ddc2 recruitment. Conversely, loss of Rad51 enhanced Mec1 focus formation independently of ssDNA formation, suggesting that Rad51 might compete for the interaction of RPA with Mec1-Ddc2. In all cases, Mec1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (24): 5137–5146.
Published: 15 December 2006
... protein RAD52. In this study, we use fluorescence resonance energy transfer (FRET) and immune-precipitation experiments to demonstrate that WRN participates in a multiprotein complex including RAD51, RAD54, RAD54B and ATR in cells where replication has been arrested by ICL. We verify the WRN-RAD51 and WRN...
Journal Articles
J Cell Sci (2006) 119 (16): 3306–3315.
Published: 15 August 2006
... for either proper RAD51 distribution or homologous pairing. It provides the basis for a model in which AFD1/REC8 controls homologous pairing through its role in axial element elongation and the subsequent distribution of the recombination machinery independent of bouquet formation. § Author...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (18): 4261–4269.
Published: 15 September 2005
... that RECQL4 foci coincide with foci formed by human Rad51 and regions of single-stranded DNA after induction of DNA double-strand breaks. In agreement with this, we also show that RECQL4 and Rad51 form a complex in human cells. Our findings suggest a role for RECQL4 in the repair of DNA double-strand breaks...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (13): 2957–2963.
Published: 01 July 2005
...); and the recombinase RAD51. We observed a marked nuclear polarization of both the maturation of SMC3 cohesin axis and the ulterior appearance of γ-H2AX and RAD51 foci, these being exclusively restricted to those chromosomal regions that first form cohesin axis stretches. This polarised distribution of recombination...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5791–5801.
Published: 15 November 2004
... to the elongation process have been subjects of ongoing debate. Here, we addressed these issues by means of fluorescence in situ hybridization, labeling of individual chromosomes by BrdU (BrdU-painting) and by immunostaining of the recombination protein, Rad51. BrdU-painting indicated that chromosomes are arranged...
Journal Articles
J Cell Sci (2002) 115 (1): 153–164.
Published: 01 January 2002
...Elke Raderschall; Alex Bazarov; Jiangping Cao; Rudi Lurz; Avril Smith; Wolfgang Mann; Hans-Hilger Ropers; John M. Sedivy; Efim I. Golub; Eberhard Fritz; Thomas Haaf After exposure of mammalian cells to DNA damage, the endogenous Rad51 recombination protein is concentrated in multiple discrete foci...