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Keywords: Rac1
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Journal Articles
In collection:
Cell migration
J Cell Sci (2023) 136 (6): jcs260373.
Published: 10 March 2023
...Zouzana Kounoupa; Simona Tivodar; Kostas Theodorakis; Dimitrios Kyriakis; Myrto Denaxa; Domna Karagogeos ABSTRACT Rho GTPases, among them Rac1 and Rac3, are major transducers of extracellular signals and are involved in multiple cellular processes. In cortical interneurons, the neurons that control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs253468.
Published: 17 September 2021
...) and to be involved in the positioning of the latter at the migrating edge. PLP2-mediated positioning of ZO-1 at the leading edge further alters actin cytoskeletal organization that involves Rac1 activation. Taken together, our findings demonstrate that PLP2, via its association with ZO-1, drives CCM in CRC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs248294.
Published: 17 February 2021
... alterations were accompanied by hyperactivation of RAC1; the dependency of transformation of p110β-binding to Rac1 revealed using a Rac1-binding mutant of p110β. Thus, PIK3CB amplification induces a transformed phenotype that is dependent upon a p110β-Rac1 signalling loop and is distinct from the transformed...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (2): jcs251140.
Published: 25 January 2021
... through its association with Rac1. Clustering of Daam2-mediated Wnt receptor complexes requires both Rac1 and PIP5K, and PIP5K promotes membrane localization of these complexes in a Rac1-dependent manner. Importantly, the localization of Daam2 complexes and Daam2-mediated canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238337.
Published: 13 March 2020
... interacts with the catalytic surface of Vav2 but not Vav1, and that Vav1 discriminates Cdc42 from Rac1 via F56 (W56 in Rac1). Finally, the Cdc42-specific inhibitor ZCL278 and the shRNA-mediated suppression of Cdc42 each prevent the inhibition of TCR-induced Ca 2+ entry by Vav2. These findings define stark...
Journal Articles
J Cell Sci (2018) 131 (15): jcs215251.
Published: 10 August 2018
...Yanyang Bai; Daji Guo; Xiaoyu Sun; Genyun Tang; Tailin Liao; Yinghui Peng; Junyu Xu; Lei Shi ABSTRACT Rac1, an important Rho GTPase that regulates the actin cytoskeleton, has long been suggested to participate in acetylcholine receptor (AChR) clustering at the postsynaptic neuromuscular junction...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2530–2540.
Published: 1 August 2017
...Yuka Ikeda; Katsuhisa Kawai; Akira Ikawa; Kyoko Kawamoto; Youhei Egami; Nobukazu Araki ABSTRACT Lamellipodia are sheet-like cell protrusions driven by actin polymerization mainly through Rac1, a GTPase molecular switch. In Fcγ receptor-mediated phagocytosis of IgG-opsonized erythrocytes (IgG-Es...
Includes: Supplementary data
Journal Articles
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Mechanobiology
J Cell Sci (2017) 130 (14): 2277–2291.
Published: 15 July 2017
... Rac1 activation associated with dramatic actin cytoskeleton rearrangements. Our study demonstrates that the mechanosensitive focal adhesion (FA) protein vinculin, and both focal adhesion kinase (FAK, also known as PTK2) and Rab5 (both the Rab5a and Rab5b isoforms) have key roles in regulating...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (6): 1064–1077.
Published: 15 March 2017
... in human breast cancer cells. Our results show that RhoG and Rac1 have independent and opposite roles in the regulation of invadopodia dynamics. We also show that SGEF (also known as ARHGEF26) is the exchange factor responsible for the activation of RhoG during invadopodia disassembly. When the expression...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (20): 3781–3795.
Published: 15 October 2015
... by the internalization of IL-4R subunits through a constitutive, Rac1-, Pak- and actin-mediated endocytosis route that causes IL-4R subunits to become enriched by about two orders of magnitude within a population of cortical endosomes. Consistently, ligand-induced receptor dimers are preferentially detected within...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2014) 127 (19): 4292–4307.
Published: 1 October 2014
... with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 from non-protrusive membrane to the leading edge. Here, we identify interactions between coronin-1C (Coro1C), RCC2 and Rac1 that focus...
Includes: Supplementary data
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Journal Articles
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Journal Articles
J Cell Sci (2013) 126 (18): 4121–4135.
Published: 15 September 2013
... ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganization events that are required for directional migration. Although the pathways that control integrin-mediated Rac1 activation are reasonably well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3295–3304.
Published: 1 August 2013
... unclear. AMF uptake to the smooth ER is inhibited by the dynamin inhibitor, dynasore, is reduced in Gp78 knockdown cells and induces the dynamin-dependent downregulation of its cell surface receptor. AMF uptake is Rac1-dependent and is inhibited by expression of dominant-negative Rac1 and the Rac1...
Includes: Supplementary data
Journal Articles