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Keywords: Rac1
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Journal Articles
J Cell Sci (2021) 134 (18): jcs253468.
Published: 17 September 2021
...) and to be involved in the positioning of the latter at the migrating edge. PLP2-mediated positioning of ZO-1 at the leading edge further alters actin cytoskeletal organization that involves Rac1 activation. Taken together, our findings demonstrate that PLP2, via its association with ZO-1, drives CCM in CRC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs248294.
Published: 17 February 2021
... alterations were accompanied by hyperactivation of RAC1; the dependency of transformation of p110β-binding to Rac1 revealed using a Rac1-binding mutant of p110β. Thus, PIK3CB amplification induces a transformed phenotype that is dependent upon a p110β-Rac1 signalling loop and is distinct from the transformed...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (2): jcs251140.
Published: 25 January 2021
... through its association with Rac1. Clustering of Daam2-mediated Wnt receptor complexes requires both Rac1 and PIP5K, and PIP5K promotes membrane localization of these complexes in a Rac1-dependent manner. Importantly, the localization of Daam2 complexes and Daam2-mediated canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238337.
Published: 13 March 2020
... interacts with the catalytic surface of Vav2 but not Vav1, and that Vav1 discriminates Cdc42 from Rac1 via F56 (W56 in Rac1). Finally, the Cdc42-specific inhibitor ZCL278 and the shRNA-mediated suppression of Cdc42 each prevent the inhibition of TCR-induced Ca 2+ entry by Vav2. These findings define stark...
Journal Articles
J Cell Sci (2018) 131 (15): jcs215251.
Published: 10 August 2018
...Yanyang Bai; Daji Guo; Xiaoyu Sun; Genyun Tang; Tailin Liao; Yinghui Peng; Junyu Xu; Lei Shi ABSTRACT Rac1, an important Rho GTPase that regulates the actin cytoskeleton, has long been suggested to participate in acetylcholine receptor (AChR) clustering at the postsynaptic neuromuscular junction...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2530–2540.
Published: 01 August 2017
...Yuka Ikeda; Katsuhisa Kawai; Akira Ikawa; Kyoko Kawamoto; Youhei Egami; Nobukazu Araki ABSTRACT Lamellipodia are sheet-like cell protrusions driven by actin polymerization mainly through Rac1, a GTPase molecular switch. In Fcγ receptor-mediated phagocytosis of IgG-opsonized erythrocytes (IgG-Es...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (14): 2277–2291.
Published: 15 July 2017
... Rac1 activation associated with dramatic actin cytoskeleton rearrangements. Our study demonstrates that the mechanosensitive focal adhesion (FA) protein vinculin, and both focal adhesion kinase (FAK, also known as PTK2) and Rab5 (both the Rab5a and Rab5b isoforms) have key roles in regulating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1064–1077.
Published: 15 March 2017
... in human breast cancer cells. Our results show that RhoG and Rac1 have independent and opposite roles in the regulation of invadopodia dynamics. We also show that SGEF (also known as ARHGEF26) is the exchange factor responsible for the activation of RhoG during invadopodia disassembly. When the expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3933–3946.
Published: 01 November 2015
...Cara Jamieson; Christina Lui; Mariana G. Brocardo; Estefania Martino-Echarri; Beric R. Henderson ABSTRACT β-Catenin transduces the Wnt signaling pathway and its nuclear accumulation leads to gene transactivation and cancer. Rac1 GTPase is known to stimulate β-catenin-dependent transcription of Wnt...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3781–3795.
Published: 15 October 2015
... by the internalization of IL-4R subunits through a constitutive, Rac1-, Pak- and actin-mediated endocytosis route that causes IL-4R subunits to become enriched by about two orders of magnitude within a population of cortical endosomes. Consistently, ligand-induced receptor dimers are preferentially detected within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3041–3054.
Published: 15 August 2015
... interacts with VE-cadherin and locally activates Rac1 at adherens junctions during the formation of nascent contacts, as assessed using a novel FRET-based Rac1 biosensor and biochemical assays. The Rac-GEF domain of Trio is responsible for the remodeling of junctional actin from radial into cortical actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 447–459.
Published: 01 February 2015
.... To address this, we have established a novel bioassay to characterize signaling cascades activated by p75NTR. We show that in COS7 cells, p75NTR expression causes a large increase in cell surface area that relies on the activation of Rac1, and we demonstrate that the p75NTR-dependent COS7 phenotype...
Journal Articles
J Cell Sci (2014) 127 (19): 4292–4307.
Published: 01 October 2014
... with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 from non-protrusive membrane to the leading edge. Here, we identify interactions between coronin-1C (Coro1C), RCC2 and Rac1 that focus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2401–2406.
Published: 01 June 2014
...Jorge Díaz; Pablo Mendoza; Rina Ortiz; Natalia Díaz; Lisette Leyton; Dwayne Stupack; Andrew F. G. Quest; Vicente A. Torres ABSTRACT Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1...
Journal Articles
J Cell Sci (2014) 127 (8): 1805–1815.
Published: 15 April 2014
... of intracellular signaling molecules. Using cells that stably express Förster resonance energy transfer (FRET) biosensors, we show here a correlation between a temporal fluctuation in the activity of Rac1 and the invasive properties of C6 glioma cells. By using long-term time-lapse imaging, we found that Rac1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4572–4588.
Published: 15 October 2013
... GTPases of the Rac subfamily, but also by RhoG or Cdc42. Here we describe viable fibroblast cell lines genetically deficient for Rac1 that lack detectable levels of Rac2 and Rac3. Rac-deficient cells were devoid of apparent lamellipodia, but these structures were restored by expression of either Rac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4121–4135.
Published: 15 September 2013
... ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganization events that are required for directional migration. Although the pathways that control integrin-mediated Rac1 activation are reasonably well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3295–3304.
Published: 01 August 2013
... unclear. AMF uptake to the smooth ER is inhibited by the dynamin inhibitor, dynasore, is reduced in Gp78 knockdown cells and induces the dynamin-dependent downregulation of its cell surface receptor. AMF uptake is Rac1-dependent and is inhibited by expression of dominant-negative Rac1 and the Rac1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1099–1108.
Published: 01 March 2013
... (Rac1) and its targets, the p21-activated kinases (Pak), are specific regulators of this pathway, acting on cortactin and actin polymerization. The present study reveals a dual and specific role of phosphatidylinositol 3-kinase (PI3K) in IL-2R endocytosis. Inhibition of the catalytic activity of PI3K...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5288–5301.
Published: 15 November 2012
...Gabriela Valls; Montserrat Codina; Rachel K. Miller; Beatriz Del Valle-Pérez; Meritxell Vinyoles; Carme Caelles; Pierre D. McCrea; Antonio García de Herreros; Mireia Duñach Summary A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β...
Includes: Supplementary data