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Keywords: Rac
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (12): jcs257709.
Published: 21 June 2021
... upregulates lamellipodin expression. This is mediated by an integrin-dependent FAK–Cas–Rac signaling module and supports stiffness-mediated lamellipodin induction. Mechanistically, we find that lamellipodin overexpression increased, and lamellipodin knockdown reduced, stiffness-induced cell cyclin expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs248880.
Published: 04 September 2020
... neutrophil-like cells display disrupted mitochondria–ER interaction, heightened intracellular Ca 2+ levels and elevated Rac activation after chemokine stimulation. Restoring a mitochondria–ER tether rescues the abnormal Ca 2+ levels, Rac hyperactivation and chemotaxis defect resulting from MFN2 depletion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs231639.
Published: 16 August 2019
... , 69 - 106 . 10.1152/physrev.00002.2012 Bokoch , G. M. , Vlahos , C. J. , Wang , Y. , Knaus , U. G. and Traynor-Kaplan , A. E. ( 1996 ). Rac GTPase interacts specifically with phosphatidylinositol 3-kinase . Biochem. J.   315 , 775 - 779 . 10.1042/bj3150775...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 2971–2983.
Published: 15 September 2017
... to these processes are complex. Here, we modify the activity of the two Rho GTPase family members Rac and Cdc42 by optogenetically recruiting specific guanine nucleotide exchange factor (GEF) DH or PH domains to defined regions of the cell membrane. We find that the localized activation of both GTPases produces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1287–1292.
Published: 01 April 2016
... – matters that are current foci of ongoing research studies. GTPase Oncogene PI3K Rac Raf Ral Mutations in the RAS gene were first reported in cancer over 30 years ago, and numerous studies have since validated mutant RAS as a driver of tumor initiation and maintenance ( Cox and Der, 2010...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2047–2056.
Published: 01 June 2015
...Shinichiro Nakahara; Koji Tsutsumi; Takuya Zuinen; Yasutaka Ohta ABSTRACT Rho family small GTPases are essential for the formation of adherens junctions in epithelial cells. Here, we found that FilGAP (also known as ARHGAP24), a Rac-specific Rho GTPase-activating protein, promoted the formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2565–2576.
Published: 01 June 2014
... that Rac1 translocates to the membrane at domain boundaries, then diffuses into raft and non-raft domains, which controls interactions. These findings resolve discrepancies in our understanding of Rac biology and identify novel mechanisms by which lipid rafts modulate Rho GTPase signaling. We thank Amy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2285–2293.
Published: 15 May 2013
... that the spatially controlled activation of receptor tyrosine kinases (RTKs) by guidance cues limits Rac activity at the leading edge, which is crucial for establishing and maintaining polarized cell protrusions at the front. However, little is known about the mechanisms by which RTKs control the local activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3811–3821.
Published: 15 November 2011
...Monica Croke; F. Patrick Ross; Matti Korhonen; David A. Williams; Wei Zou; Steven L. Teitelbaum Cdc42 mediates bone resorption principally by stimulating osteoclastogenesis. Whether its sister GTPase, Rac, meaningfully impacts upon the osteoclast and, if so, by what means, is unclear. We find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3535–3546.
Published: 15 October 2010
... neurite retraction in both N1E-115 cells and cerebellar granule neurones. However, how PIP5Ks are regulated or how they induce neurite retraction is not well defined. Here, we show that neurite retraction induced by PIP5Kβ is dependent on its interaction with the low molecular weight G protein Rac. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4049–4061.
Published: 15 November 2009
... levels must be maintained within a defined range for embryogenesis to proceed normally. * Author for correspondence ( pdmccrea@mdanderson.org ) 2 9 2009 © The Company of Biologists Limited 2009 2009 Gastrulation Rho Rac To investigate mechanisms underlying δ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (17): 2805–2813.
Published: 01 September 2008
... and metastasis through its dual actin-bundling and active PKC-binding activities. Rac was implicated as a regulator of fascin-dependent colon carcinoma cell migration in vitro. Here, we tested the hypothesis that Rac regulates the interaction of fascin with active PKC. The major conventional PKC in colon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (3): 379–390.
Published: 01 February 2008
...Wassim Abou-Kheir; Beth Isaac; Hideki Yamaguchi; Dianne Cox Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous (WAVE) proteins play a major role in Rac-induced actin dynamics, but Rac does not bind directly to WAVE proteins. It has been proposed that either the insulin receptor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3700–3712.
Published: 15 October 2007
... the stroma can influence tumor behavior by regulating the tissue phenotype, we explored the role of extracellular matrix signaling and tissue organization in epithelial survival. We report that elevated (α6)β4 integrin-dependent Rac-Pak1 signaling supports resistance to apoptosis in mammary acini...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3138–3146.
Published: 01 September 2007
... phosphoinositide 3-kinases (PI 3-kinases). Both Rac and Ras have been shown to regulate actin polymerization and activate PI 3-kinase. However, the coordination of Rac, Ras and PI 3-kinase activation during epidermal growth factor (EGF)-stimulated protrusion has not been analyzed. We examined PI 3-kinase-dependent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (15): 2672–2682.
Published: 01 August 2007
... 24 5 2007 © The Company of Biologists Limited 2007 2007 β-catenin Shear stress Laminin α6β4 integrin Rac PI 3-kinase Cell cycle The effects of mechanical force induced by fluid shear stress on the activity of several signal transduction pathways in endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (13): 2143–2149.
Published: 01 July 2007
...., Madhani, H., Fink, G. R. and Ravichandran, K. S. ( 2002 ). Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol. 4 , 574 -582. Chung, S., Gumienny, T. L., Hengartner, M. O. and Driscoll, M. ( 2000 ). A common set of engulfment genes mediates removal...
Journal Articles
J Cell Sci (2007) 120 (8): 1480–1490.
Published: 15 April 2007
... sheath of hair follicles, we generated transgenic mice expressing a dominant inhibitory mutant of Rac, N17Rac1, under the control of the keratin 14 promoter. These mice do not exhibit an overt skin phenotype but show protracted skin wound re-epithelialization. Investigation into the underlying mechanisms...
Journal Articles
J Cell Sci (2007) 120 (1): 86–100.
Published: 01 January 2007
..., the precise molecular mechanisms that underlie cell-cell adhesion formation remain unclear. Here we show that Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE)-mediated reorganization of actin, downstream of Rac plays an important role in normal development of cadherin-dependent cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3316–3324.
Published: 15 August 2006
... formation and decreased Rac activation following PDGF treatment. In addition, we describe a novel interaction between palladin and Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos-1. Eps8 was identified...
Includes: Multimedia, Supplementary data