1-20 of 30
Keywords: Rab5
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... homolog, Bph1. We show that Bph1 is an endosomal protein and an effector of the minor Rab5 isoform Ypt52. Strikingly, bph1 Δ mutant cells have lipidated Atg8 on their endosomes, which is sorted via late endosomes into the vacuole lumen under non-autophagy-inducing conditions. In agreement...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2021) 134 (21): jcs259192.
Published: 4 November 2021
... the multivesicular body (MVB). Completion of MVB sorting is accompanied by maturation of the endosome into a late endosome, an event that requires inactivation of the early endosomal GTPase Rab5 (herein referring to generically to all isoforms). Here, we show that HD-PTP links ESCRT function with endosomal...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2021) 134 (8): jcs254185.
Published: 27 April 2021
...Frode Miltzow Skjeldal; Linda Hofstad Haugen; Duarte Mateus; Dominik M. Frei; Anna Vik Rødseth; Xian Hu; Oddmund Bakke ABSTRACT Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4087–4096.
Published: 15 December 2017
... of the epidermal growth factor and insulin receptors . Biochim. Biophys. Acta   916 , 220 - 226 . 10.1016/0167-4838(87)90112-9 Balaji , K. , Mooser , C. , Janson , C. M. , Bliss , J. M. , Hojjat , H. and Colicelli , J. ( 2012 ). RIN1 orchestrates the activation of RAB5 GTPases...
Journal Articles
J Cell Sci (2015) 128 (13): 2373–2387.
Published: 1 July 2015
.... Published by The Company of Biologists Ltd 2015 Summary: Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin, revealing new facets of the endosomal escape process with relevance to antigen cross-presentation. Shiga toxin Rab6 Rab5 Rab7 Sec22B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2849–2861.
Published: 1 July 2014
... purification and mass spectrometry, we identify a complex containing RasGAP together with Sprint, which is a Ras effector and putative activator of the endocytic GTPase Rab5. Formation of the RasGAP–Sprint complex requires the SH2 domains of RasGAP and tyrosine phosphorylation of Sprint. RasGAP and Sprint...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (17): 3835–3847.
Published: 1 September 2013
..., the small GTPase Rab5, a crucial regulator of early endosome dynamics, promotes cell migration in vitro and in vivo . Precisely how Rab5 participates in these events remains to be determined. Considering that focal adhesions represent structures crucial to cell migration, we specifically asked whether Rab5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1307–1316.
Published: 15 March 2013
... protein receptors (SNAREs) and can tether membranes. Owing to the presence of specific subunits, CORVET is a Rab5 effector complex, whereas HOPS can bind efficiently to late endosomes and lysosomes through Rab7. Based on the recently described overall structure of the HOPS complex and a number of in vivo...
Journal Articles
J Cell Sci (2012) 125 (23): 5887–5896.
Published: 1 December 2012
... is determined in part by the RAS effector RIN1, a guanine nucleotide exchange factor (GEF) for RAB5 GTPases. EGFR degradation was slowed by RIN1 silencing, enhanced by RIN1 overexpression and accelerated by RIN1 localization to the plasma membrane. RIN1 also directly activates ABL tyrosine kinases, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (9): 1564–1570.
Published: 1 May 2011
...- and Rab5-dependent endocytosis leads to a phenotype that is undistinguishable from that of the ninaE -null mutant. Importantly, the corresponding endocytic activity is essential to prevent early onset of rhabdomere degeneration. In conclusion, we propose that Rh1 function in promoting RTW morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (6): 939–946.
Published: 15 March 2010
... and larvae. We found that the IAC undergoes turnover in MTJs and that this process is mediated by clathrin-dependent endocytosis. Moreover, the small GTPase Rab5 can regulate the proportion of IAC components that undergo turnover. Also, altering Rab5 activity weakened MTJs, resulting in muscle defects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 360–368.
Published: 1 February 2010
... LRP6 from the lipid raft. Dkk1 internalized LRP6 in a Rab5-dependent mechanism to prevent phosphorylation mediated by CK1γ. The internalized LRP6 was recycled back in a Rab11-dependent mechanism to the cell-surface membrane, and the recycled LRP6 again responded to Wnt3a and Dkk1. Internalized Dkk1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (1): 25–35.
Published: 1 January 2009
...Julien Compagnon; Louis Gervais; Mabel San Roman; Sophy Chamot-Bœuf; Antoine Guichet Phosphoinositides have emerged as key regulators of membrane traffic through their control of the localization and activity of several effector proteins. Both Rab5 and phosphatidylinositol (4,5)-bisphosphate...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (6): 1053–1062.
Published: 15 March 2006
...Xinjun Zhang; Xi He; Xin-Yuan Fu; Zhijie Chang The small GTPases Rab5 and Rab21 are closely related, and play essential roles in endocytic trafficking. Rab5 is regulated by VPS9-domain-containing guanine nucleotide exchange factors. Here, we describe a new VPS9-domain protein with ankyrin repeats...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (17): 3583–3590.
Published: 1 September 2003
...Hideyuki Shimizu; Satoru Kawamura; Koichi Ozaki Rab5 small GTPase is a famous regulator of endocytic vesicular transport from plasma membrane to early endosomes. In neurons, Rab5 is found not only on endocytic vesicles in cell bodies but also on synaptic vesicles in nerve terminals. However...
Journal Articles
Journal Articles
J Cell Sci (2002) 115 (24): 4755–4763.
Published: 15 December 2002
...Yang Hu; Jen-Zen Chuang; Kai Xu; Timothy G. McGraw; Ching-Hwa Sung Rab5, a member of the small GTPase family of proteins, is primarily localized on early endosomes and has been proposed to participate in the regulation of early endosome trafficking. It has been reported that phosphatidylinositol 3...