... membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classified as fast recycling from early endosomes (Rab4) and slow recycling from perinuclear recycling endosomes (Rab11), and both routes...

... on the mother centriole, which nucleates the primary cilium. However, the regulatory mechanisms underlying CV formation have not yet been fully elucidated. Here, we found that the atypical small GTPase RAB-like 3 (RABL3) is necessary to assemble primary cilia in human cells. RABL3 directly interacts with RAB11...

... in the expansion of tubular recycling compartments and stabilised Rab11 tubules, pointing to a function for LITAF and CDIP1 in membrane scission. Consistent with this, co-depletion of LITAF and CDIP1 impairs integrin recycling and cell migration. § These authors contributed equally to this work...

... in this process is poorly understood. Here, we identify Rab11a and Rab11b as regulators of Ca 2+ -induced lysosome exocytosis. Interestingly, Rab11-positive vesicles transiently interact with lysosomes at the cell periphery, indicating that this interaction is required for the last steps of lysosome exocytosis...

..., the Hherisomes, which contain the majority of intracellular Hh. Hherisomes are recycling tubular endosomes, and their formation is specifically boosted by overexpression of Hh. Expression of Rab11, a small GTPase involved in recycling endosomes, boosts the size of Hherisomes and their Hh concentration...

...Futaba Osaki; Takahide Matsui; Shu Hiragi; Yuta Homma; Mitsunori Fukuda ABSTRACT The small GTPase Rab11 (herein referring to the Rab11A and Rab11B isoforms) plays pivotal roles in diverse physiological phenomena, including the recycling of membrane proteins, cytokinesis, neurite outgrowth...

...Yuna Otsuka; Takunori Satoh; Nozomi Nakayama; Ryota Inaba; Hitomi Yamashita; Akiko K. Satoh ABSTRACT Rab11 is essential for polarized post-Golgi vesicle trafficking to photosensitive membrane rhabdomeres in Drosophila photoreceptors. Here, we found that Parcas (Pcs), recently shown to have guanine...

.../ Highlighted Article: We describe a comparative analysis of the functions of myosin motors at the Golgi complex in cells normalized by micropatterns and identify MYO1C as a novel player at the Golgi. Arp2/3 Golgi apparatus Myosin1 Pleckstrin holology domain Rab11 Rab6 MYO6 MYO18A MYH9 Myosin...

... assays, knockout of CAMSAP3, but not of CAMSAP2, caused microtubule re-organization into a more radial centrosomal array, redistribution of Rab11-positive (also known as Rab11A) endosomes from the apical cell surface to the pericentrosomal region and inhibition of actin brush border formation...

... that is dependent on the transport of components to assembly sites. Previously, it has been shown that vRNPs are carried by recycling endosome vesicles, resulting in a change of Rab11 distribution. Here, we describe that vRNP binding to recycling endosomes impairs recycling endosome function, by competing for Rab11...

... 2 2 2015 © 2015. Published by The Company of Biologists Ltd 2015 Rab11 Rab8 Enterocyte Intestinal polarity Microvilli Syntaxin 3 The maintenance of polarity in epithelial cells requires the establishment of specialized apical structures including apical microvilli...

... has been shown to undergo recycling after BDNF stimulation. We have previously reported that full-length TrkB (TrkB-FL) are recycled through a Rab11-dependent pathway upon BDNF stimuli, which is important for the translocation of TrkB-FL into dendritic spines and for the maintenance of prolonged BDNF...

... proteins. On the one hand, p0071 depletion induced a perinuclear accumulation of Rab11, suggesting a role of p0071 in the anterograde transport of Rab11 from the pericentrosomal region to the plasma membrane but not in retrograde transport. p0071 as well as Rab11 depletion increased transferrin receptor...

...Senye Takahashi; Keiji Kubo; Satoshi Waguri; Atsuko Yabashi; Hye-Won Shin; Yohei Katoh; Kazuhisa Nakayama Summary Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates...

[email protected] ) 28 12 2010 © 2011. 2011 Abscission Cytokinesis Membrane Trafficking Microtubules RAB11 RAB11-FIP3 Once mammalian cells have successfully replicated and segregated chromosomes into their respective destinations, they undergo a process of physical separation, called...

...Conor P. Horgan; Sara R. Hanscom; Rushee S. Jolly; Clare E. Futter; Mary W. McCaffrey Several protein families control intracellular transport processes in eukaryotic cells. Here, we show that the Rab11 GTPase effector protein Rab11-FIP3 (henceforth, FIP3) directly interacts with the dynein light...

... of Tb MBAP1-depleted cells with that of cells in which endocytosis or exocytosis has been specifically inhibited by RNAi against clathrin of RAB11, reveals that Tb MBAP1 is essential for both incoming and recycling membrane traffic. During differentiation of the organism from bloodstream to insect stage...

... to agonist. For the transferrin receptor, CXCR2, and the M 4 -muscarinic acetylcholine receptor, trafficking through the RE and receptor recycling is regulated by the small GTPase rab11. The precise role of the RE and rab11 in regulating the cellular trafficking of the β 2 AR is not understood. We therefore...

... the transferrin receptor (TfR) is found associated with the vesicles. Interestingly, this cell line has been shown to possess high amounts of Rab11 compared with other Rab proteins. To assess the regulation of transferrin receptor release via exosome secretion by Rab11 in this cell type, K562 cells were stably...

... of a previously undefined endosomal compartment in T. brucei based on identification of a new trypanosome gene ( TbRAB11 ) homologous to Rab11/Ypt31. Northern and western analyses indicated that TbRAB11 expression was significantly upregulated in the bloodstream stage of the parasite, the first trypanosome Rab...