...://www.biologists.com/user-licence-1-1/ Summary: TBC1D5 is identified in an siRNA screen as the GAP for Rab7b, and controls the distribution and membrane kinetics of this small GTPase, mediating endosome to trans-Golgi transport. Rab7b Rab proteins GAP GTPase TBC domains Endosomes Trans-Golgi...

... and being physically present on a proportion of the Golgi-to-ER tubular intermediates. Combinatorial depletions of Rab proteins also revealed previously undescribed functional co-operation and physical co-occurrence between several Rab proteins. Our approach therefore provides a novel and robust strategy...

...Marita Borg; Oddmund Bakke; Cinzia Progida ABSTRACT Rab proteins are small GTPases that regulate transport between the different compartments of the endomembrane system in eukaryotic cells. Here, we show that Rab7b, a Rab that controls the transport between late endosomes and the trans Golgi...

[email protected] ) 10 2 2010 © 2010. 2010 Rab proteins Rab7 Rab7b Endosomes Lysosomes Lysosomal enzymes Rab proteins are important regulators of all aspects of membrane trafficking ( Cai et al., 2007 ; Grosshans et al., 2006 ; Markgraf et al., 2007 ). Indeed, they are monomeric...

...-Rab3A and ECFP-Rab27A colocalised with one another. The extent of colocalisation between EGFP-Rab3A or EGFP-Rab27 and SGII increased after longer times post transfection suggesting that these Rab proteins are preferentially recruited to newly synthesised granules. Following the release of immature...

...) and GM130 (5-nm gold, arrowheads (left panel) in HEK293 cells. G, Golgi. Bars, 200 nm. We next asked whether mAtg9 colocalized with the small-GTPase proteins Rab4, Rab5, Rab6, Rab7, Rab9 and Rab11. GFP-fusions of the early endosomal Rab proteins, GFP-Rab4, GFP-Rab5 and GFP-Rab11 ( Sonnichsen et al...

...Jeremy C. Simpson; Gareth Griffiths; Marianne Wessling-Resnick; Jack A. M. Fransen; Holly Bennett; Arwyn T. Jones Rab proteins comprise a family of monomeric GTPases that control cellular membrane traffic. Rab21 is a poorly characterised member with no known function. Human Rab21 cDNA from K562...

... mechanisms responsible for targeting Rabs to specific intracellular compartments, however, remain poorly understood. The divergent C-terminal hypervariable region was postulated to contain Rab targeting information. We generated a series of hybrid Rab proteins by exchanging the hypervariable domains of Rab1a...

...Rosana Mesa; Cristina Salomón; Marcelo Roggero; Philip D. Stahl; Luis S. Mayorga Soon after endocytosis, internalized material is sorted along different pathways in a process that requires the coordinated activity of several Rab proteins. Although abundant information is available about...

... * Present address: National Public Health Institute, Department of Biochemistry, Mannerheimintie 166, SF-00300, Helsinki, Finland 05 07 1993 07 09 1993 © 1993 by Company of Biologists 1993 rab proteins rab12 rab22 rab24 small GTPases cDNA library screening RACE PCR c- myc...

.... * Author for correspondence 05 06 1993 22 07 1993 © 1993 by Company of Biologists 1993 rab proteins small G proteins rhodopsin membrane transport and sorting TGN In frog rod photoreceptors newly synthesized rhodopsin is sorted from the Golgi to the rod outer segment...

...Matthias Peter; Philippe Chavrier; Erich A. Nigg; Marino Zerial ABSTRACT rab proteins are low molecular weight GTP-binding proteins highly related to Yptlp and Sec4p, which are involved in the control of secretion in yeast Saccharo-myces cerevisiae . Morphological and biochemical studies have shown...