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Keywords: Rab GTPase
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Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (15): jcs259037.
Published: 03 August 2021
...); after budding from the TGN, granules undergo modifications, including an increase in size. These changes occur during a poorly understood process called secretory granule maturation. Here, we leverage the Drosophila larval salivary glands as a model to characterize a novel role for Rab GTPases during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs241141.
Published: 27 May 2020
... Riedel , F. , Galindo , A. , Muschalik , N. and Munro , S. ( 2017 ). The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases . J. Cell Biol.   217 , 601 - 617 . 10.1083/jcb.201705068 Rivera-Molina , F. E. and Novick , P. J. ( 2009...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs235044.
Published: 10 February 2020
... and a unique leucine residue in its C-terminal tail as a way to regulate neuronal differentiation. Glycosylphosphatidylinositol GPI-anchored protein Glycerophosphodiester phosphodiesterase Rab GTPase Neurodegeneration Neuroblastoma Glycosylphosphatidylinositol (GPI)-anchored proteins...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2019) 132 (14): jcs226001.
Published: 17 July 2019
... by the coordinated action of various proteins. These include centrosome and midbody ring-associated proteins [e.g. MKLP-1 (also known as KIF23), centriolin, BRUCE and Cep55], kinases (e.g. Plk-1 and Aurora B) and regulators of intracellular traffic like Rab GTPases and their effectors, endosomal sorting complexes...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (24): jcs222034.
Published: 10 December 2018
... provide a ‘cradle’ for the longin SNARE VAMP7 mediating its incorporation into prebudding complex at the Golgi/TGN during sensory receptor ciliary trafficking. VAMP7 Cilium SNARE Rab GTPase Sensory receptor Rhodopsin Primary cilia are evolutionarily conserved near-ubiquitous plasma...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs215889.
Published: 05 October 2018
... and neurites). Here, we report that inhibiting membrane recycling reduces the number of TNT-connected cells and that overexpression of Rab11a and Rab8a increases the number of TNT-connected cells and the propagation of vesicles between cells in co-culture. We demonstrate that these two Rab GTPases act...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2007–2017.
Published: 15 June 2017
... VPS-34 inactivates RAB-5 via recruitment of the TBC-2 Rab GTPase-activating protein. We found that loss of VPS-34 caused a phenotype with large late endosomes, as with loss of TBC-2, and that Rab5 activity (mice have two Rab5 isoforms, Rab5a and Rab5b) is increased in Vps34-knockout mouse embryonic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1509–1517.
Published: 01 May 2017
... disassembled for successful abscission. However, the mechanism that actively removes actin during abscission is poorly understood. In this Commentary, we will focus on the latest findings regarding the emerging role of the MICAL family of oxidoreductases in F-actin disassembly and describe how Rab GTPases...
Journal Articles
J Cell Sci (2015) 128 (22): 4126–4137.
Published: 15 November 2015
...Simone Kälin; David T. Hirschmann; Dominik P. Buser; Martin Spiess ABSTRACT Rab GTPases control membrane identity, fusion and transport by interaction with effector proteins. Effectors that influence the activation–inactivation cycle of their own or other Rab proteins contribute to the timely...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 1043–1051.
Published: 01 March 2014
...Margarita Cabrera; Mirjana Nordmann; Angela Perz; David Schmedt; Andreas Gerondopoulos; Francis Barr; Jacob Piehler; Siegfried Engelbrecht-Vandré; Christian Ungermann ABSTRACT To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5897–5905.
Published: 01 December 2012
.... Published by The Company of Biologists Ltd 2012 Caenorhabditis elegans Cortical granule exocytosis Rab GTPase Separase After fertilization, oocytes undergo a series of dramatic changes collectively called oocyte-to-embryo transition, which are essential for the onset of embryogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5758–5769.
Published: 01 December 2012
.... * Author for correspondence ( m.katan@ucl.ac.uk ) 17 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Caenorhabditis elegans Rab GTPase Cortical granule exocytosis Separase Phosphoinositide signalling plays an important role in various aspects of cell motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (7): 1361–1370.
Published: 01 April 2006
... 2B215, Bethesda, MD 20892, USA 15 12 2005 © The Company of Biologists Limited 2006 2006 Epithelium Brush border Spectrin Rab GTPase Endosome Drosophila A brush border is characteristic of many mature transporting epithelia, and is conserved across vertebrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (26): 6377–6389.
Published: 15 December 2004
...Amanda M. Kotzer; Federica Brandizzi; Ulla Neumann; Nadine Paris; Ian Moore; Chris Hawes Rab GTPases are universal key regulators of intracellular secretory trafficking events. In particular, Rab 5 homologues have been implicated in endocytic events and in the vacuolar pathway. In this study, we...
Includes: Supplementary data