... of ATPsynβ (a Complex V subunit), which produces higher levels of reactive oxygen species (ROS) than pdsw knockdown, instead synergizes with Hipk to potentiate JNK activation and the downstream induction of matrix metalloproteinases. Accordingly, ATPsynβ knockdown suppresses Hipk-induced tumor-like growth...

... 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Here, we explore how the deformability of macrophages impact their phagocytic ability and report a ROS-dependent cytoplasmic stiffening that reduces their phagocytic...

... and for the role of ATM in oxidative stress, atrophy and aging. Atm Skeletal muscle ROS Atrophy Slow myosin Myopathy Ataxia telangiectasia (A-T) is a rare genetic disorder caused by mutations in ATM gene that cause ATM kinase instability and loss of function ( Uziel et al., 1996 ). In humans...

... of the daughter cell mass within the mother cell wall at cytokinesis. Differential desiccation tolerance across the five species, assessed from photosynthetic efficiency during desiccation/rehydration cycles, was accompanied by differential accumulation of intracellular reactive oxygen species (ROS) detected...

... exposed to high glucose, which overexpressed and secreted active TGF-β1, Arg protein and activity was downregulated. A further TGF-β1 increase was induced by Arg silencing with siRNA, as with the Arg tyrosine kinase inhibitor Imatinib. In the cells exposed to high glucose, reactive oxygen species (ROS...

... attributed. Summary: NAF-1 is a major player in the metabolic regulation of breast cancer cells through its effects on cellular Fe ion distribution, mitochondrial metabolism and the induction of apoptosis. NEET proteins NAF-1 Mitochondria ROS Apoptosis Cancer Iron (Fe) ions (which...

...Carlos Wilson; M. Tulio Núñez; Christian González-Billault ABSTRACT Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS...

... interests. 28 05 2014 19 09 2014 © 2014. Published by The Company of Biologists Ltd 2014 Mitochondrial fusion Metabolic stress HDAC6 MFN1 ROS Acetylation The ability to use a diverse set of fuel sources in response to changing nutrient environments is crucial...

... laboratory fish species Japanese medaka. Here, pigment cells are transformed by an oncogenic receptor tyrosine kinase in fish expressing GFP throughout their vasculature. We show that angiogenesis occurs in a reactive oxygen species (ROS)- and NF-κB-dependent, but hypoxia-independent manner. Intriguingly, we...

... (MOMP) leading to caspase-3 activation. Additionally, previous studies have implicated lysosomal membrane permeability (LMP) and formation of reactive oxygen species (ROS) as early steps of TNFα-induced apoptosis. However, how these two events connect to MOMP and caspase-3 activation has been largely...

... membranes MAM Ryanodine receptor Uniporter Ca 2+ signalling reactive oxygen species ROS Isolated mitochondria are competent to produce energy on their own and are not particularly responsive to changes in their environment that mimic intracellular signals. These observations supported...

.... * These authors contributed equally to this work ‡ Authors for correspondence ( [email protected] ; [email protected] ) © 2012. 2012 ROS Apoptosis Autophagy Nitric oxide Living organisms derive energy from the breakdown of the molecular bonds of nutrients, and then convert...

... ) 3 1 2012 © 2012. 2012 ROS Actin Cofilin Mitochondria Multi-drug resistance Yeast The actin cytoskeleton is a major cellular component that facilitates a plethora of essential functions. These include the generation and maintenance of cell morphology and polarity...

... of Myc by a mechanism not previously reported in normal lung fibroblasts. We also show that reactive oxygen species (ROS) derived from steady-state Romo1 expression are necessary for cell cycle entry of quiescent cells. From this study, we suggest that the generation of ROS mediated by pre-existing Romo1...

... growth-factor deprivation. Serum starvation stimulates the catalytic activity and Y311 phosphorylation of PKCδ through reactive oxygen species (ROS) and the Src family kinases. Mutation of PKCδ at Y311 and Y322, both of which are phosphorylation sites for Src, impairs its activation and ability...

... by downregulation of the expression of Fis1 and Drp1, two proteins regulating mitochondrial fission. Targeted photodamage of mitochondria induced the formation of reactive oxygen species (ROS), which triggered mitochondrial fragmentation and loss of membrane potential in young cells, whereas senescent cells proved...

...Simone Lipinski; Andreas Till; Christian Sina; Alexander Arlt; Helmut Grasberger; Stefan Schreiber; Philip Rosenstiel Generation of microbicidal reactive oxygen species (ROS) is a pivotal protective component of the innate immune system in many eukaryotes. NOD (nucleotide oligomerisation domain...

.... * Author for correspondence (e-mail: [email protected] ) 13 12 2008 © The Company of Biologists Limited 2009 2009 NADPH oxidase Duox ROS Lung epithelial cells Migration Regulated generation of reactive oxygen species (ROS) has been the hallmark of phagocytes...

...Catherine F. Cowell; Heike Döppler; Irene K. Yan; Angelika Hausser; Yoshio Umezawa; Peter Storz Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor...

... plays a physiological role in the differentiation of yeast colonies by facilitating elaboration of distinct zones of cell death. * Author for correspondence (e-mail: [email protected] ) 3 11 2008 © The Company of Biologists Limited 2009 2009 PKA ROS Ras Actin...