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Keywords: RNAi
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Journal Articles
J Cell Sci (2020) 133 (13): jcs244863.
Published: 07 July 2020
...Li Sun; Xiao-Min Liu; Wen-Zhu Li; Yuan-Yuan Yi; Xiangwei He; Yamei Wang; Quan-Wen Jin ABSTRACT In the fission yeast Schizosaccharomyces pombe , both RNAi machinery and RNAi-independent factors mediate transcriptional and posttranscriptional silencing and heterochromatin formation. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs209551.
Published: 06 July 2018
... regulating cytokine receptor levels, and their activity and dimerisation, we analysed the highly conserved JAK/STAT pathway in Drosophila , which acts via a single receptor, known as Domeless. We performed a genome-wide RNAi screen in Drosophila cells, identifying MASK as a positive regulator of Domeless...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 1046–1058.
Published: 01 March 2016
... are likely transcribed from the sequences destined for deletion; however, the dsRNAs in parental somatic nuclei are unexpected, and PCR analyses suggested that they were transcribed in this nucleus. Deficiency in the RNA interference (RNAi) pathway led to abnormal aggregations of dsRNA in both the parental...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (3): 649–661.
Published: 01 February 2012
... regulation and provide a set of new genes involved in regulation of integrin function. 29 9 2011 © 2012. 2012 Integrin activity RNAi Invasion Integrins are a family of cell surface adhesion receptors that regulate the ability of cells to interact with their surroundings ( Gahmberg...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (5): 812–819.
Published: 01 March 2011
... autophagy might be pathological. * Author for correspondence ( jeff.mackeigan@vai.org ) 9 11 2010 © 2011. 2011 FYVE PTPσ PtdIns3 P RNAi Autophagy Phosphatase In addition to the well-characterized role of phosphatidylinositol-3-phosphate (PtdIns3 P ) in endocytosis...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 690–698.
Published: 01 March 2010
... able to detect a significant number of these cells in DjRbAp48 RNAi animals. Parallel to the decrease in neoblasts, a reduction in the number of differentiated cells and the presence of apoptotic-like neoblasts were detectable in RNAi animals. These findings suggest that DjRbAp48 is not involved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3481–3491.
Published: 01 October 2009
...: Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA 2 7 2009 © The Company of Biologists Limited 2009 2009 p8 (Nupr1) G1 Myoblast MyoD Gene trap RNAi Satellite cell p300 p68 Ddx5 Yeast two-hybrid Myogenic differentiation...
Journal Articles
J Cell Sci (2008) 121 (20): 3393–3402.
Published: 15 October 2008
... associated with tumorigenesis and particularly breast cancer. By using RNA interference (RNAi) to downregulate the expression of Pea3 and/or Erm in a mammary cancer cell line, we present evidence for a role of these factors in proliferation, migration and invasion capacity of cancer cells. We have used...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (8): 1284–1292.
Published: 15 April 2008
... as by proteins that are capable of focusing kinetochore fibers (K fibers) even in the absence of a centrosome. Here, we have performed a small-scale RNA interference (RNAi) screen of known or suspected pole-related proteins in Drosophila S2 cells. An unexpected outcome of this screen was the finding that one...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (24): 4367–4376.
Published: 15 December 2007
...Viktor I. Korolchuk; Martin M. Schütz; Carolina Gómez-Llorente; João Rocha; Nico R. Lansu; Stephanie M. Collins; Yogesh P. Wairkar; Iain M. Robinson; Cahir J. O'Kane To identify novel proteins required for receptor-mediated endocytosis, we have developed an RNAi-based screening method...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (21): 3715–3722.
Published: 01 November 2007
... knowledge. * Author for correspondence (e-mail: rwollman@ucdavis.edu ) 17 9 2007 © The Company of Biologists Limited 2007 2007 High-throughput microscopy (HTM) Image analysis RNAi Genome-wide screen High-throughput microscopy (HTM) allows researchers to acquire images...
Journal Articles
J Cell Sci (2007) 120 (21): 3870–3882.
Published: 01 November 2007
... polymerization Adherens junctions RNAi RhoA Formins Myosin II It is well established that both the formation and maintenance of cell-cell junctions in epithelial cells depend on the actin cytoskeleton. Formation of cadherin-mediated cell-cell junctions (adherens junctions) is accompanied by profound...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2924–2934.
Published: 15 August 2007
... body, malpighian tubules and in the gonads of both sexes. Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility and severely reduced viability. In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. An RNAi construct...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 1978–1989.
Published: 15 June 2007
..., The Institute for Genomic Research, Rockville, MD 20850, USA 17 4 2007 © The Company of Biologists Limited 2007 2007 DNA rearrangement RNAi Ciliate Heterochromatin Chromodomain The separation of germ line and the soma allows for both extensive specialization within the current...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 648–657.
Published: 15 February 2007
... (e-mail: stephen.high@manchester.ac.uk ) 22 11 2006 © The Company of Biologists Limited 2007 2007 Endoplasmic reticulum Oligosaccharyltransferase RNAi STT3 N-glycosylation typically occurs co-translationally and is the most common form of protein modification in the ER...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4811–4818.
Published: 01 December 2006
... microscope as described previously ( Cram et al., 2003 ). RNAi for hlh-2 was performed as described above using ppn-1 ::GFP (BC15734) nematodes. After hatching, nematodes were grown on hlh-2 RNAi or control bacteria for 48 hours at 23°C. The distal ends of gonads from RNAi-treated nematodes were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (19): 4071–4078.
Published: 01 October 2006
... of Liverpool, Liverpool, L69 3BX, UK 21 7 2006 © The Company of Biologists Limited 2006 2006 Clathrin Mitosis Endocytosis RNAi Clathrin is a three-legged molecule, or triskelion, which consists of three ∼190 kDa (1,675 residue) heavy chains each with an associated ∼25 kDa light...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3399–3412.
Published: 15 August 2006
... and Arl1, the product of the Arf72A locus. Additionally, Cbs remains independent of the endoplasmic reticulum throughout cleavage. The use of RNAi, Arf72A mutant analysis and ectopic expression of the GRIP domain, shows that cycling of Cbs during mitosis is required for the centrosome cycle. The effects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (6): 1105–1117.
Published: 15 March 2006
... procyclic form. Triple RNAi analysis showed MCA2, MCA3 and MCA5 to be essential in the bloodstream form, with parasites accumulating pre-cytokinesis. Nevertheless, triple null mutants (Δ mca2/3Δmca5 ) could be isolated after sequential gene deletion. Thereafter, Δ mca2/3Δmca5 mutants were found to grow well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (13): 2813–2825.
Published: 01 July 2005
... (trichocysts). The functional significance of the V-ATPase in Paramecium was investigated by RNA interference (RNAi), using a recently developed feeding method. A novel strategy was used to block the expression of all six c- or both F-subunits simultaneously. The V-ATPase was found to be crucial...