... live tissues and complete animals hold particular promise, as only such complex systems display the full range of RNA processing. The data presented so far reveal extremely complex RNA dynamics, which are far from being isotropic. It can be expected that the techniques discussed here will soon...

... of mRNA to the cytoplasm. * Author for correspondence (e-mail: jeffrey.nickerson@umassmed.edu ) 11 2 2008 © The Company of Biologists Limited 2008 2008 RNA export RNA processing RNA helicase SRm160 Exon junction complex Fig. 9. UAP56 K95N has a dominant-negative...

... of Biologists Limited 2007 2007 Splicing RNA processing Nuclear organisation Alternative splicing affects up to 70% of human genes, and is thought to be a key factor enabling metazoan complexity ( Johnson et al., 2003 ). Patterns of RNA splicing are thought to be established by a cellular...

... bodies also contain other RNA-binding and RNA-processing proteins, such as the ATP-dependent DEAD-box RNA helicase MVH (mouse VASA homolog), and components of the RNA decay pathway and the miRNA pathway such as miRNAs, Dicer and Argonaute proteins Ago2 and Ago3 ( Kotaja et al., 2006 ). MIWI is proposed...

.... These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease. All results presented are representative of four repeated experiments and 150-200 transfected...

... ). RNA processing Nuclear bodies Phosphorylation SMN snRNA snoRNA © The Company of Biologists Limited 2003 2003 6 10 2002 * Author for correspondence (e-mail: gxm26@po.cwru.edu ) ...

... Protein kinase Ribonuclease RNA Processing Signal transduction Cells respond to the accumulation of malfolded proteins in the endoplasmic reticulum (ER) by activating signaling pathways that regulate the expression of genes whose products mitigate the effects of ER stress and attenuate protein...