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Keywords: RILP
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Journal Articles
J Cell Sci (2024) 137 (9): jcs261765.
Published: 13 May 2024
... phenocopy the alterations in tubulation and CI-M6PR trafficking. Mechanistically, pH neutralization increases the assembly of the V 1 G 1 subunit (encoded by ATP6V1G1 ) of the V-ATPase on endosomal membranes, which stabilizes GTP-bound Rab7 via RILP, a known interactor of Rab7 and V 1 G 1 . We propose...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (9): jcs260691.
Published: 12 May 2023
... of the trafficking adaptor protein RILP, which, as previously shown, results from inflammasome-mediated caspase-1 activation. RILP cleavage can be blocked by overexpressing a dominant negative, non-cleavable form of RILP (ncRILP). EV preparations from ncRILP-expressing cells are, by themselves, sufficient...
Includes: Supplementary data
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Proteostasis
J Cell Sci (2014) 127 (12): 2697–2708.
Published: 15 June 2014
...Maria De Luca; Laura Cogli; Cinzia Progida; Veronica Nisi; Roberta Pascolutti; Sara Sigismund; Pier Paolo Di Fiore; Cecilia Bucci ABSTRACT Rab-interacting lysosomal protein (RILP) is a downstream effector of the Rab7 GTPase. GTP-bound Rab7 recruits RILP to endosomal membranes and, together...
Includes: Supplementary data
Journal Articles
Journal Articles
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Metabolism
J Cell Sci (2010) 123 (7): 1151–1159.
Published: 1 April 2010
... cells. Lysosomes were located more peripherally in Rab7-shRNA-expressing cells and these cells were more invasive than control cells. Overexpression of the Rab7 effector protein, RILP, resulted in a juxtanuclear location of lysosomes and reduced HGF-induced invasion. Together, these results suggest...
Includes: Supplementary data