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Keywords: RHOA
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Journal Articles
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Cell migration
J Cell Sci (2021) 134 (17): jcs258767.
Published: 2 September 2021
... as they move. These stresses are characteristically tensile in nature and have often been inferred to arise when moving cells pull upon the cell–cell adhesions that hold them together. We now report that epithelial tension at adherens junctions between migrating cells also increases due to an increase in RhoA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254409.
Published: 22 April 2021
... steps, which initiate in anaphase. The central dogma in cytokinesis is that the anaphase spindle provides cues to direct contractile ring assembly in the equatorial plane. Moving the spindle to a new location generates active RhoA and causes a new furrow to form in the location that bisects...
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Journal Articles
J Cell Sci (2020) 133 (5): jcs236166.
Published: 2 March 2020
... the RHOA–ROCK–myosin light chain (MLC) pathway. We confirmed activation of RHOA downstream of Dectin-1 using activity assays and stress fiber formation. Through phagocytosis assays, we found direct evidence for the importance of RHOA-ROCK-MLC signaling in the process of phagocytosis of C. albicans...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs223230.
Published: 18 February 2019
... program, whereas microenvironmental conditions such as reduced tissue oxygenation have an inhibitory effect. We investigated the effects of hypoxia on myofibroblastic properties and linked this to RhoA activity. Hypoxia reversed the myofibroblastic phenotype of primary fibroblasts. This was accompanied...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs204644.
Published: 1 February 2018
...Arzu Ulu; Wonkyung Oh; Yan Zuo; Jeffrey A. Frost ABSTRACT The neuroepithelial cell transforming gene 1A (Net1A, an isoform of Net1) is a RhoA subfamily guanine nucleotide exchange factor (GEF) that localizes to the nucleus in the absence of stimulation, preventing it from activating RhoA. Once...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
... other family members, ARHGAP42 acts preferentially as a GAP for RhoA. We show that Src principally phosphorylates ARHGAP42 on tyrosine 376 (Tyr-376) in the short linker between the BAR-PH and GAP domains. The expression of ARHGAP42 variants in mammalian cells was used to elucidate its regulation. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 892–902.
Published: 1 March 2017
... cytoskeleton. Finally, we provide evidence that the effects of vimentin on stress fibers are mediated by activation of RhoA through its guanine nucleotide exchange factor GEF-H1 (also known as ARHGEF2). Vimentin depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 420–428.
Published: 15 January 2017
... that actin-based pushing under the control of the formin protein Fmn1 drives apical emergence in nascent multiciliated epithelial cells (MCCs), but little else is known about this actin network or the control of Fmn1. Here, we explore the role of the small GTPase RhoA in MCC apical emergence. Disruption...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3018–3029.
Published: 15 August 2015
... on immobilized VCAM and display bleb-like protrusions on the endothelium. Our data further show that PrP regulates ligand-induced integrin activation. Finally, we found that PrP controls the activation of several proteins involved in cell adhesion and migration, including RhoA and its effector cofilin, as well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 992–1000.
Published: 1 March 2015
...Kun Gao; Wenwen Tang; Yuan Li; Pingzhao Zhang; Dejie Wang; Long Yu; Chenji Wang; Dianqing Wu ABSTRACT A hallmark of neutrophil polarization is the back localization of active RHOA and phosphorylated myosin light chain (pMLC, also known as MYL2). However, the mechanism for the polarization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 913–922.
Published: 1 March 2015
...Eun Hyeon Song; Wonkyung Oh; Arzu Ulu; Heather S. Carr; Yan Zuo; Jeffrey A. Frost ABSTRACT Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2014) 127 (5): 1117–1127.
Published: 1 March 2014
... whether Aβ regulation of microtubule dynamics can occur independently of its action on tau. RhoA has been implicated in neurotoxicity by Aβ but the mechanism by which this activation generates cytoskeletal changes is also unclear. We found that oligomeric Aβ 1-42 induced the formation of stable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (19): 4514–4526.
Published: 1 October 2013
...; however, the specific signaling pathways leading to migration remain poorly understood. Previously, we have shown that CXCL12 stimulation of migration depends on temporal regulation of RhoA. However, the specific RhoGEF that translates CXCR4 signaling into RhoA activity and cell motility is unknown. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3271–3277.
Published: 1 August 2013
... density and cultured for 5 days. Scale bars: 20 µm. ( C ) Vertical images ( z section) of B showing disrupted monolayer morphology in TEM4-depleted cells. ( D ) Immunoblot analysis of active RhoA and phosphorylated (pSer19) myosin light chain 2 (pMLC2) in MDCK cells expressing the indicated canine...
Includes: Supplementary data
Journal Articles