... in G2 phase to prevent genomic instability. Senescence onset in G2 requires p53 (also known as TP53) and retinoblastoma protein (RB, also known as RB1) family tumour suppressors, but how they are regulated to convert a temporary cell cycle arrest into a permanent one remains unknown. Here, we show...

...Emmi Rotgers; Sheyla Cisneros-Montalvo; Mirja Nurmio; Jorma Toppari ABSTRACT Maintenance of the differentiated state and cell cycle exit in adult Sertoli cells depends on tumor suppressor retinoblastoma protein (RB, also known as RB1). We have previously shown that RB interacts with transcription...

...Gabriel M. Gordon; Tianyi Zhang; Jiong Zhao; Wei Du Summary Synthetic lethality is a potential strategy for cancer treatment by specifically promoting the death of cancer cells with particular defects such as the loss of the RB ( RB1 ) tumor suppressor. We previously showed that inactivation...

... of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK © 1995 by Company of Biologists 1995 DP/E2F Rb cell cycle transcription In mammalian cells the cellular transcription factor DRTF1/E2F plays a crucial role in co-ordinating early cell cycle progression...

...Tarek Mahdi; André Brizard; Christine Millet; Pierre Doré; Joseph Tanzer; Alain Kitzis ABSTRACT In this work we intended to determine whether p53 and/or retinoblastoma (Rb) tumor suppressor genes are involved at specific stages in the process of in vitro human peripheral stem cell hematopoiesis...