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Keywords: R-Ras
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Journal Articles
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (1): 51–61.
Published: 1 January 2010
... of Fam38A in epithelial cells inactivates endogenous β1 integrin, reducing cell adhesion. Fam38A mediates integrin activation by recruiting the small GTPase R-Ras to the ER, which activates the calcium-activated protease calpain by increasing Ca 2+ release from cytoplasmic stores. Fam38A-induced integrin...
Includes: Supplementary data
Journal Articles
Markku Lehto, Mikko I. Mäyränpää, Teijo Pellinen, Pekka Ihalmo, Sanna Lehtonen, Petri T. Kovanen, Per-Henrik Groop, Johanna Ivaska, Vesa M. Olkkonen
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (5): 695–705.
Published: 1 March 2008
... as in certain forms of cancer. We assessed the function of ORP3 in HEK293 cells and in human macrophages. We show that ORP3 interacts with R-Ras, a small GTPase regulating cell adhesion, spreading and migration. Gene silencing of ORP3 in HEK293 cells results in altered organization of the actin cytoskeleton...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (7): 1307–1319.
Published: 1 April 2006
...Aude S. Ada-Nguema; Harry Xenias; Michael P. Sheetz; Patricia J. Keely R-Ras, an atypical member of the Ras subfamily of small GTPases, enhances integrin-mediated adhesion and signaling through a poorly understood mechanism. Dynamic analysis of cell spreading by total internal reflection...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (18): 3729–3738.
Published: 15 September 2003
...Johanna Furuhjelm; Johan Peränen R-Ras promotes cell adhesion and activation of integrins through a process that is yet unknown. We show here that active R-Ras (38V) promotes the formation of focal adhesions and a spread cell shape. By contrast, the dominant-negative mutant of R-Ras (43N) reduces...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (7): 1357–1366.
Published: 1 April 2001
...Annette J. Self; Emmanuelle Caron; Hugh F. Paterson; Alan Hall ABSTRACT R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and M-Ras. Activated versions of Ras and TC21 are highly transforming in a variety of cell lines and mutated...