... mitosis, is also required for exit from quiescence. mis4-450 mutants fail to maintain viability at quiescence (G0) and exhibit a dikaryon-like phenotype when resuming mitosis after passage of G0. Mis4 NIPBL Fission yeast Quiescence Cohesin Dikaryon Japan Society for the Promotion...

... 2024 19 2 2025 © 2025. Published by The Company of Biologists 2025 http://www.biologists.com/user-licence-1-1/ Nucleus Chromatin Transcription Quiescence Yeast Cryo-ET Ministry of Education - Singapore http://dx.doi.org/10.13039/501100001459 R-154-000-B42-114...

...Margaret Hung; Hsiao-Fan Lo; Grace E. L. Jones; Robert S. Krauss ABSTRACT Skeletal muscle stem cells (MuSCs, also called satellite cells) are the source of the robust regenerative capability of this tissue. The hallmark property of MuSCs at homeostasis is quiescence, a reversible state of cell...

...Rebeka Tomasin; Ana Maria Rodrigues; Antonio Carlos Manucci; Alexandre Bruni-Cardoso ABSTRACT Cell context is key for cell state. Using physiologically relevant models of laminin-rich extracellular matrix (lrECM) induction of mammary epithelial cell quiescence and differentiation, we provide...

...Yipeng Du; Parul Gupta; Shenlu Qin; Matthew Sieber ABSTRACT Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in physiology and metabolism. Quiescence plays essential roles in a wide variety of biological processes, ranging from microbial sporulation...

... actively contributes to the stationary phase establishment. Quiescence Fission yeast Stationary phase Cyclin-dependent kinase Glucose Nucleus Quiescence is the non-dividing but proliferation-competent state observed in all living organisms ( Broach, 2012 ; De Virgilio, 2012 ; Gray et...

... – the primary cilium – as a sensory antenna, have since been extensively studied, but the role of the cilium–centrosome axis in cell fate is still emerging. In this Opinion piece, we view cellular quiescence and tissue homeostasis from the vantage point of the cilium–centrosome axis. We focus on a less explored...

...Hardik P. Gala; Debarya Saha; Nisha Venugopal; Ajoy Aloysius; Gunjan Purohit; Jyotsna Dhawan ABSTRACT Adult stem cells persist in mammalian tissues by entering a state of reversible quiescence, referred to as G 0 , which is associated with low levels of transcription. Using cultured myoblasts...

... commitment. Our results indicate that TLE4 represses Pax7-mediated Myf5 transcriptional activation by occupying the −111 kb Myf5 enhancer to maintain quiescence. Loss of TLE4 function causes Myf5 upregulation, an increase in satellite cell numbers and altered differentiation dynamics during regeneration...

... as TJP2) in the polarized epithelium. The distribution of Cx43 is altered by pro-inflammatory breast cancer risk factors such as leptin and high-fat diet, as shown in cell culture and on tissue biopsy sections. The control of polarity-mediated quiescence and MSO may contribute to the tumor-suppressive...

...Isabelle Sagot; Damien Laporte ABSTRACT Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a temporary non-proliferating state. Although central for a variety of essential processes including tissue homeostasis, development and aging, quiescence is poorly...

... use transformed cells, but the majority of cells in an adult organism have exited the cell cycle. Here, we review endocytosis in dividing, quiescent and terminally differentiated cells. Endocytosis Clathrin-mediated endocytosis Clathrin-independent endocytosis Cell cycle Mitosis Quiescence...

... such example, the quiescent adult mammalian stem cell, and examines concepts underlying our understanding of quiescence that can be attributed to studies in yeast. We discuss the metabolic, signaling and gene regulatory events that control entry and exit into quiescence in yeast. These processes and events...

...-mail: [email protected] ) 25 6 2007 © The Company of Biologists Limited 2007 2007 mDia1 MyoD SRF RhoA Adhesion-dependent signaling Quiescence Synchronized myoblasts β-catenin TCF APC Skeletal muscle formation occurs through a series of regulated events involving...

... phase in proliferating cells and upon cell cycle exit in quiescence, senescence and differentiation. Upon cell cycle exit LINT-25 accumulated in heterochromatin foci, and LAP2α protein levels were downregulated by proteasomal degradation. Although LAP2α was not required for the upregulation...

... ) 6 1 2005 © The Company of Biologists Limited 2005 2005 Nuclear structure Three-dimensional culture Breast Morphogenesis Quiescence Heterochromatin protein 1 Changes in higher-order nuclear organization may be a key event in the control of cellular phenotypes...

... that calmodulin may be associated with the mechanism underlying flagellar quiescence induced by 10 −4 M Ca 2+ . In the middle region ( Fig. 2B ), the sliding velocity decreased as the vibration frequency decreased below the natural beat frequency, but plateaued as the vibration frequency was increased over...

... abruptly with the onset of quiescence, but instead declines gradually. The decline in replication capacity, which affects both the number of nuclei induced to replicate and their subsequent rate of DNA synthesis, is accompanied by a fall in the level of chromatin-bound MCM2. When quiescent nuclei...

...) appears to be a good candidate for controlling this quiescence. Indeed, various mutations in the TGF-β signalling pathway are responsible for neoplasic proliferation of primitive stem/progenitor cells in human tissues of various origins. In hemopoietic single cell culture assays, blocking autocrine...

... for A-type lamins. Using the mouse Swiss 3T3 cell line as a model, the change in two A-type lamins, lamins A and C, during cellular quiescence has been investigated. This well established model system mimics the first stages of differentiation when cells exit the cell cycle. In fact, quiescence in Swiss 3T3...