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Keywords: Quality control
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Journal Articles
J Cell Sci (2020) 133 (21): jcs240366.
Published: 10 November 2020
... are located along the secretory pathway, which ensure the fidelity of such protein signals (quality control). Proteins that pass the checkpoints operated in the endoplasmic reticulum (ER) by the binding immunoglobulin protein (BiP; also known as HSPA5 and GRP78) and the calnexin–calreticulin systems, must...
Journal Articles
J Cell Sci (2018) 131 (20): jcs218024.
Published: 26 October 2018
... , localization of the enzyme PIG-B in the nuclear envelope (NE) is important for GPI anchor synthesis, and the NE and the perinuclear ER form a platform for the GPI modification. Glycosylphosphatidylinositol Nuclear envelope Endoplasmic reticulum PIG Quality control Functional organelle zones...
Includes: Supplementary data
Journal Articles
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Autophagy
J Cell Sci (2018) 131 (19): jcs214304.
Published: 04 October 2018
... receptor during selective autophagy and how its activity can be integrated with the UPS. We will discuss these recent insights in the context of protein quality control and the emerging concept of cellular organization mediated by phase transitions. However, with regard to p62 as a cargo receptor...
Journal Articles
J Cell Sci (2018) 131 (6): jcs210948.
Published: 20 March 2018
...Ganapathi Kandasamy; Claes Andréasson ABSTRACT During protein quality control, proteotoxic misfolded proteins are recognized by molecular chaperones, ubiquitylated by dedicated quality control ligases and delivered to the 26S proteasome for degradation. Proteins belonging to the Hsp70 chaperone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2663–2671.
Published: 15 August 2017
... tight quality control systems. The p53 protein family constitutes one of the most important quality surveillance systems in cells. Whereas p53 has become famous for its role as the guardian of the genome in its function as the most important somatic tumor suppressor, p63 has been nicknamed ‘guardian...
Journal Articles
J Cell Sci (2014) 127 (14): 3017–3023.
Published: 15 July 2014
... quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope.   Mol. Biol. Cell   22 , 4726 – 4739 . 10.1091/mbc.E11--05--0463 Giaever   G. , Chu   A. M. , Ni   L. , Connelly   C. , Riles   L. , Véronneau   S. , Dow   S. , Lucau-Danila   A. , Anderson   K...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1161–1168.
Published: 15 March 2014
... for the quality control of peroxisomes in leaves and for proper plant development under natural growth conditions. The ATG5 coding region (nucleotides 1–1014) was amplified by PCR from full-length cDNA using the primers 5′-TCCCCCGGGATGGCGAAGGAAGCGG-3′ and 5′-GCTCTAGATCACCTTTGAGGAGCTTTC-3′. The resulting PCR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3893–3903.
Published: 01 September 2013
... reticulum (SR) Ca 2+ transport ATPase (SERCA) 2b and that this interaction determines ER Ca 2+ content and the regulation of ER–mitochondria Ca 2+ crosstalk. In contrast, non-palmitoylated calnexin interacts with the oxidoreductase ERp57 and performs its well-known function in quality control. Interestingly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1429–1439.
Published: 15 March 2013
... – 364 . 10.1016/j.ceb.2006.06.008 Brodsky   J. L. , Skach   W. R. ( 2011 ). Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.   Curr. Opin. Cell Biol.   23 , 464 – 475 . 10.1016/j.ceb.2011.05.004 Brodsky   J...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4465–4472.
Published: 15 December 2009
... in the ER, suggesting that the quality control system of this compartment did not permit further traffic of folding-defective polypeptides through the secretory system ( Kaushal and Khorana, 1994 ; Sung et al., 1991 ). Rhodopsin is an archetypal seven-transmembrane G-protein-coupled receptor (GPCR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (18): 3322–3329.
Published: 15 September 2009
... with PtdIns(4,5) P 2 is lost upon unfolding of FGF2. Our combined findings suggest an intrinsic quality-control mechanism that ensures extracellular accumulation of FGF2 in a biologically active form. In the current study, we introduce a novel experimental system that monitors the folding state of the FGF2...
Journal Articles
J Cell Sci (2009) 122 (13): 2228–2239.
Published: 01 July 2009
...Basil Schaheen; Hope Dang; Hanna Fares Quality-control mechanisms of protein folding of transmembrane and secreted proteins is mediated by endoplasmic-reticulum-associated degradation (ERAD), which is used to detect and to degrade misfolded proteins in the ER. The ERAD machinery consists...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4373–4380.
Published: 01 November 2006
... chaperones has revealed important new information on the mechanisms regulating protein folding and quality control. Tight regulation of N -glycan modifications is crucial to maintain protein quality control, to ensure the synthesis of functional polypeptides and to avoid constipation of the ER with folding...
Journal Articles
J Cell Sci (2006) 119 (20): 4353–4363.
Published: 15 October 2006
...Katja Heusser; Hebao Yuan; Ioana Neagoe; Andrei I. Tarasov; Frances M. Ashcroft; Blanche Schwappach Arginine (Arg)-based endoplasmic reticulum (ER)-localization signals are involved in the quality control of different heteromultimeric membrane protein complexes. ATP-sensitive potassium (K ATP...
Journal Articles
J Cell Sci (2006) 119 (4): 615–623.
Published: 15 February 2006
...David B. Williams Calnexin and calreticulin are related proteins that comprise an ER chaperone system that ensures the proper folding and quality control of newly synthesized glycoproteins. The specificity for glycoproteins is conferred by a lectin site that recognizes an early oligosaccharide...
Journal Articles
J Cell Sci (2006) 119 (2): 360–369.
Published: 15 January 2006
... not cause DIG exclusion because a Pma1-Ub fusion protein is not significantly excluded from DIGs. We suggest that ubiquitylation of Pma1-10 represents a component of a quality control mechanism that targets the misfolded protein for removal from the plasma membrane. Rapid internalization of Pma1-10 caused...
Journal Articles
J Cell Sci (2004) 117 (14): 2937–2949.
Published: 15 June 2004
...Sherri Svedine; Tao Wang; Ruth Halaban; Daniel N. Hebert The endoplasmic reticulum (ER) quality-control machinery maintains the fidelity of the maturation process by sorting aberrant proteins for ER-associated protein degradation (ERAD), a process requiring retrotranslocation from the ER lumen...
Journal Articles
J Cell Sci (2002) 115 (24): 4947–4956.
Published: 15 December 2002
... and/or to target misfolded proteins for proteasomal degradation, like the membrane-bound chaperone protein calnexin. The role of Sec61β in the quality control of secretory proteins could thus consist of maintaining the chaperone calnexin in the vicinity of the translocation pore. Such a proximity allows calnexin...