... dephosphorylate Sty1 to reduce kinase activity. Therefore, tight control of MAPK phosphatases is central for stress adaptation and for cell division to resume. In contrast to Pyp1, the fission yeast Pyp2 MAPK phosphatase is under environmental control. Pyp2 has a unique sequence (the linker region) between...

... in nutrient supply experienced in vivo. We previously reported that inhibition of fission yeast Tor1 promotes mitotic onset by controlling the activity of the stress MAPK pathway through regulation of its phosphatase Pyp2 ( Petersen and Nurse, 2007 ). We have extended these observations of Tor1...