.... , Linster , E. , Boyer , J. B. , Weidenhausen , J. , Mueller , J. , Armbruster , L. , Lapouge , K. , De La Torre , C. , Bienvenut , W. , Sticht , C. et al. ( 2022 ). HYPK promotes the activity of the N(alpha)-acetyltransferase A complex to determine proteostasis...

... deletion mutants with either enhanced or reduced protein aggregation levels during arsenite exposure. We show that many of the identified factors are crucial to safeguard protein homeostasis (proteostasis) and to protect cells against arsenite toxicity. The hits were enriched for various functions...

...) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues ( ScFIT ), SCS3 and YFT2 , in the proteostasis and stress response pathways. While LD biogenesis and basal endoplasmic reticulum (ER) stress-induced unfolded protein response...

... but not critical for proteostasis ( Fig. 4 D,E). Fig. 4. Arabidopsis pbac5 mutants have reduced 26S proteasome activity and are hypersensitive to proteotoxic stress. (A) Diagrams of the Arabidopsis PBAC1 , PBAC2 and PBAC5 genes. The boxes represent coding regions (green) or UTRs (yellow), and lines...

.... ( 2013 ). Diversity in the origins of proteostasis networks—a driver for protein function in evolution . Nat. Rev. Mol. Cell Biol.   14 , 237 - 248 . 10.1038/nrm3542 Rappsilber , J. , Ishihama , Y. and Mann , M. ( 2003 ). Stop and go extraction tips for matrix-assisted laser...

... to recently identified substrates are reviewed. FAT10 Ubiquitin Ubiquitin-like modifier Proteasome VCP Autophagy Proteostasis Deutsche Forschungsgemeinschaft 10.13039/501100001659 CRC969/C01 CRC969/C09 GR1517/25-1 Velux Stiftung 10.13039/100007214 1029 Swiss...

... of these aspects. Furthermore, we discuss the evolution from thinking of satellites as mere facilitators of protein trafficking to the centrosome to thinking of them being key regulators of protein localization and cellular proteostasis for a diverse set of pathways, making them of broader interest to fields...

... by The Company of Biologists Ltd 2018 Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions. Quality control Proteostasis Selective autophagy Cargo receptor Degradation Lysosome...

... , A. , Zhang , Y. , Wen , Z. , Florens , L. and Li , R. ( 2017 ). Cytosolic proteostasis through importing of misfolded proteins into mitochondria . Nature   543 , 443 - 446 . 10.1038/nature21695 Schneider , C. A. , Rasband , W. S. and Eliceiri , K. W. ( 2012 ). NIH...

...Christina Klimek; Barbara Kathage; Judith Wördehoff; Jörg Höhfeld ABSTRACT Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis...

...Guilian Xu; Amrutha Pattamatta; Ryan Hildago; Michael C. Pace; Hilda Brown; David R. Borchelt ABSTRACT The capacity of the cell to produce, fold and degrade proteins relies on components of the proteostasis network. Multiple types of insults can impose a burden on this network, causing protein...

... evolved powerful and sophisticated mechanisms to maintain protein homeostasis (proteostasis) ( Balch et al., 2008 ). Protein quality control systems are normally very efficient at maintaining protein homeostasis over several decades of life. However, the fact that protein aggregates build up later in life...

... ( Fig. 4B ; Swift et al., 2013b ). Cell mechanics Mechanotransduction Extra-cellular matrix Nucleus Nucleoskeleton Proteostasis Evolution has likely driven our tissues and organs to fulfill their roles with optimal efficiency and, of course, viability. Mature tissues need...

... The authors declare no competing interests. © 2014. Published by The Company of Biologists Ltd 2014 Cancer progression Chromatin environment Heat shock factor Organismal stress response Proteostasis Transcription Heat shock factor 1 (HSF1) is a prime integrator of transcriptional...