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Keywords: Proteostasis
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Journal Articles
J Cell Sci (2023) 136 (14): jcs260766.
Published: 18 July 2023
.... , Linster , E. , Boyer , J. B. , Weidenhausen , J. , Mueller , J. , Armbruster , L. , Lapouge , K. , De La Torre , C. , Bienvenut , W. , Sticht , C. et al. ( 2022 ). HYPK promotes the activity of the N(alpha)-acetyltransferase A complex to determine proteostasis...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (21): jcs248526.
Published: 5 November 2020
...) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues ( ScFIT ), SCS3 and YFT2 , in the proteostasis and stress response pathways. While LD biogenesis and basal endoplasmic reticulum (ER) stress-induced unfolded protein response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs248526.
Published: 5 November 2020
...) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues ( ScFIT ), SCS3 and YFT2 , in the proteostasis and stress response pathways. While LD biogenesis and basal endoplasmic reticulum (ER) stress-induced unfolded protein response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... seedlings, indicating that this chaperone is important but not critical for proteostasis ( Fig. 4 D,E). To confirm that this proteotoxic-stress phenotype was linked to the absence of PBAC5, we tested the sensitivity of homozygous pbac5-3 seedlings complemented with a transgene expressing either WT HA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (14): jcs246041.
Published: 21 July 2020
... by their very different function in that FAT10 does serve as a proteasomal degradation signal whereas ISG15 does not. FAT10 Ubiquitin Ubiquitin-like modifier Proteasome VCP Autophagy Proteostasis Summary: The determination of the structure of FAT10 has advanced our understanding...
Journal Articles
J Cell Sci (2020) 133 (14): jcs246041.
Published: 21 July 2020
...-like modifier. Here, the latest insights about the function of non-covalent binding and conjugation to recently identified substrates are reviewed. FAT10 Ubiquitin Ubiquitin-like modifier Proteasome VCP Autophagy Proteostasis Deutsche Forschungsgemeinschaft 10.13039/501100001659...
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2020) 133 (1): jcs239566.
Published: 2 January 2020
... of these aspects. Furthermore, we discuss the evolution from thinking of satellites as mere facilitators of protein trafficking to the centrosome to thinking of them being key regulators of protein localization and cellular proteostasis for a diverse set of pathways, making them of broader interest to fields...
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2020) 133 (1): jcs239566.
Published: 2 January 2020
... of these aspects. Furthermore, we discuss the evolution from thinking of satellites as mere facilitators of protein trafficking to the centrosome to thinking of them being key regulators of protein localization and cellular proteostasis for a diverse set of pathways, making them of broader interest to fields...
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (19): jcs214304.
Published: 4 October 2018
.... , Von Kriegsheim , A. , Behrends , C. and Wilkinson , S. ( 2018 ). CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis . Dev. Cell   44 , 217 - 232 e11 . 10.1016/j.devcel.2017.11.024 Streich , F. C. , Jr. and Lima , C. D...
Journal Articles
J Cell Sci (2018) 131 (11): jcs209122.
Published: 12 June 2018
... Supersaturation Proteostasis Neurodegeneration Ubiquitomics Degron Proteasome Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is a progressive neurodegenerative disease leading to paralysis of voluntary muscles due to the death of motor neurons in the brain and spinal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs209122.
Published: 12 June 2018
...://www.biologists.com/user-licence-1-1/ Summary: Misfolded SOD1 contributes to ubiquitin proteasome system dysfunction in a cell model of ALS. Hence, ubiquitin homeostasis is an important marker of changes in ALS pathology. Protein aggregation Ubiquitin SOD1 ALS Supersaturation Proteostasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2781–2788.
Published: 1 September 2017
...Christina Klimek; Barbara Kathage; Judith Wördehoff; Jörg Höhfeld ABSTRACT Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2781–2788.
Published: 1 September 2017
...Christina Klimek; Barbara Kathage; Judith Wördehoff; Jörg Höhfeld ABSTRACT Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1892–1901.
Published: 1 May 2016
...Guilian Xu; Amrutha Pattamatta; Ryan Hildago; Michael C. Pace; Hilda Brown; David R. Borchelt ABSTRACT The capacity of the cell to produce, fold and degrade proteins relies on components of the proteostasis network. Multiple types of insults can impose a burden on this network, causing protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3861–3869.
Published: 1 November 2015
.... Protein quality control Proteostasis Stress responses Cells are well equipped to survey and maintain the health of their proteomes; they employ chaperones that bind to non-native polypeptides to prevent aggregation and to facilitate the folding of proteins, as well as degradation systems...
Journal Articles
J Cell Sci (2015) 128 (21): 3861–3869.
Published: 1 November 2015
.... Protein quality control Proteostasis Stress responses Cells are well equipped to survey and maintain the health of their proteomes; they employ chaperones that bind to non-native polypeptides to prevent aggregation and to facilitate the folding of proteins, as well as degradation systems...