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Keywords: Proteolysis
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Journal Articles
J Cell Sci (2024) 137 (2): jcs261898.
Published: 18 January 2024
... of their activity, and their trafficking pathways and target proteins, as well as their impact on health and disease. Cell invasion Intracellular trafficking Invadosomes Matrix metalloproteinases Motor proteins Proteolysis Rab GTPases Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (16): jcs257790.
Published: 18 August 2021
... proteins, providing insight into the link between WNT signalling and the ubiquitin–proteasome system. ERAD Proteolysis Ubiquitylation EVI/WLS Wnt signalling Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 259332240/RTG 2099 SFB1324 Cell–cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs253088.
Published: 26 July 2021
.../βTrCP-binding (SB) motif is critical for ZYG-1 degradation, substantiating a conserved mechanism by which ZYG-1/Plk4 stability is regulated by the SKP1–CUL1–F-box (Slimb/βTrCP)-protein complex (SCF Slimb/βTrCP )-dependent proteolysis via the conserved SB motif in C. elegans . Furthermore, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (9): jcs231662.
Published: 7 May 2019
... the recognition of cellular location signals embedded into the P2 residues of most proteins. N-end rule pathway Ubr1 Ubiquitin-mediated degradation Proteolysis Protein quality control Protein misfolding CytoQC N-degron National University of Singapore 10.13039/501100001352...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (7): 1126–1135.
Published: 1 April 2011
... ) 23 11 2010 © 2011. 2011 Fusion Dynamin-related proteins Mitochondria Proteolysis Ubiquitylation A proper control of membrane dynamics and content mixing between organelles is essential for cellular communication ( Martens and McMahon, 2008 ). Endocytosis and mitochondrial...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2009) 122 (22): 4208–4217.
Published: 15 November 2009
...) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. EMBO J. 19 , 3945 -3955. Brandeis, M. and Hunt, T. ( 1996 ). The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J. 15 , 5280 -5289...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 601–608.
Published: 1 March 2008
... to inhibit Spg1p signalling. * Author for correspondence (e-mail: [email protected] ) 19 11 2007 © The Company of Biologists Limited 2008 2008 Cytokinesis S. pombe GTPase activating protein (GAP) Proteolysis Coordination of mitosis and cytokinesis is important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (10): 1977–1984.
Published: 15 May 2006
... function and, when deregulated, leads to the development of diseases such as polyQ disorders and other neurodegenerative conditions. e-mail: [email protected] 4 4 2006 © The Company of Biologists Limited 2006 2006 Cell nucleus Proteasome Protein aggregation Proteolysis...
Journal Articles
J Cell Sci (2005) 118 (22): 5231–5242.
Published: 15 November 2005
... nuclear proteolysis. Here, fluorogenic precursor substrates enabled detection of proteasomal activity in nucleoplasmic cell fractions (turnover 0.0541 μM/minute) and nuclei of living cells (turnover 0.0472 μM/minute). By contrast, cell fractions of nucleoli or nuclear envelopes did not contain proteasomal...
Journal Articles
J Cell Sci (2005) 118 (17): 3829–3838.
Published: 1 September 2005
... of calpain activity. Knockout and knockdown approaches have also contributed significantly to our knowledge of calpain biology, particularly with respect to the specific functions of different calpain isoforms. The mechanisms by which calpain-mediated proteolysis of individual substrates contributes to cell...
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J Cell Sci (2002) 115 (14): 3007–3014.
Published: 15 July 2002
... turnover is reduced, we concluded that the half-life of GFP u was not affected by Ubc6p overexpression. In parallel experiments, an increased GFP u level was observed upon overexpression of ubiquitin K48R, a dominant inhibitor of ubiquitin-dependent proteolysis (data not shown). Thus, similar...
Journal Articles
J Cell Sci (2001) 114 (13): 2491–2499.
Published: 1 July 2001
... Proteolysis Chaperone Translocation Transport Many intracellular proteins must be translocated across a membrane before they reach their proper intracellular location. Mechanisms of protein secretion across the plasma membrane of bacteria ( Nishiyama et al., 1999 ; Bernstein, 2000 ) as well...
Journal Articles
J Cell Sci (2001) 114 (11): 2135–2143.
Published: 1 June 2001
... to the formation of spores. An mfr1 null mutant completes meiosis II but remains with high levels of cdc13 and cdc2 kinase activity and has considerably delayed spore formation. By analogy with the mitotic cell cycle, where proteolysis and inactivation of cdc2 kinase are necessary to trigger mitotic exit...
Journal Articles
J Cell Sci (2001) 114 (1): 111–118.
Published: 1 January 2001
... Pintelaan 185, B-9000 Ghent, Belgium ‡ Author for correspondence ( e-mail: [email protected] ) © 2001 by Company of Biologists 2001 E-cadherin/catenin complex Ectodomain shedding Matrix metalloproteinase Proteolysis Invasion E-cadherin is a calcium-dependent cell-cell...