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Keywords: Protein-protein interaction
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Journal Articles
J Cell Sci (2020) 133 (11): jcs240283.
Published: 11 June 2020
...: The Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site. Cell polarity Proteinprotein interaction SPLIFF Positive feedback Split-ubiquitin Yeast Cdc42...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs236505.
Published: 14 November 2019
... and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning. Mammalian target of rapamycin mTOR AKT PKB Dictyostelium Proteinprotein interaction Rictor Mammalian, or mechanistic, target of rapamycin (mTOR) is a serine...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (1): jcs210419.
Published: 8 January 2018
... of GTPase activation based on tripartite split-GFP that enables the evaluation of GEF activity and the effect of modulators of GTPase activation in a high-content analysis. GTPase activation Split-GFP Proteinprotein interaction GEF Guanine nucleotide exchange factor Cell-based assays High...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1027–1036.
Published: 15 March 2017
... ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation. Epithelial Na + channel Derlin-1 Ubiquitylation Proteinprotein interaction Ubiquitin-mediated proteasome degradation Hypertension...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 3983–3988.
Published: 1 November 2016
... luminal domain is the minimal requirement to form the sarcoplasmic reticulum Ca 2+ sensor, which governs cardiac Ca 2+ homeostasis and reliable heartbeat. Ca 2+ intracellular release Calsequestrin Excitation-contraction coupling Luminal Ca 2+ sensor Proteinprotein interaction Ryanodine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3621–3630.
Published: 1 October 2015
... downstream factors. FoxO1 inhibits basal transcription and gonadotropin-releasing hormone (GnRH)-mediated induction of the gene encoding luteinizing hormone β ( Lhb ) in pituitary gonadotrope cells. This response is likely to occur through proteinprotein interactions between the FoxO1 DNA-binding domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3210–3222.
Published: 1 September 2015
... proteome analysis to determine LPPR1-interacting proteins and identifies a functional cooperation between LPPR family members. Membrane protrusion Protein-protein interaction Filopodia Actin The lipid phosphate phosphatase-related proteins (LPPRs), also known as plasticity-related genes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2302–2313.
Published: 15 June 2015
... . 10.1074/mcp.M900430-MCP200 Lin , X. , Li , X. , Jiang , M. , Chen , L. , Xu , C. , Zhang , W. , Zhao , H. , Sun , B. , Xu , X. , Nan , F. , et al. ( 2012 ). An activity-based probe reveals dynamic proteinprotein interactions mediating IGF-1R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2351–2362.
Published: 15 June 2015
... and RFP fusion proteins for immunoprecipitation with anti-GFP nanobody, proteinprotein interactions could be reproducibly visualized by directly observing the immunoprecipitates under a microscope, and evaluated using a microplate reader, without requiring immunoblotting. Using this ‘visible...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3614–3624.
Published: 15 August 2014
... of the daughter cell at the end of cytokinesis ( Barr and Gruneberg, 2007 ; Onishi et al., 2013 ). Cytokinesis IQGAP F-BAR protein Proteinprotein interaction Iqg1p is synthesized late during the cell cycle when its interaction with Mlc1p targets the protein immediately to the bud neck ( Fig...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 35–46.
Published: 1 January 2011
... ( nils.johnsson@uni-ulm.de ) 9 9 2010 © 2011. 2011 Constraint interaction network Proteinprotein interaction Organelle inheritance Polarized growth Protein kinase Protein phosphatase Systems biology Inactivation of proteins that participate in more than one cellular process leads...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3121–3132.
Published: 1 October 2008
... for the development of effective therapeutic agents. * Author for correspondence (e-mail: sdedhar@interchange.ubc.ca ) 7 8 2008 © The Company of Biologists Limited 2008 2008 Cancer Development Extracellular matrix Integrin-linked kinase Protein-protein interaction Signal transduction...
Journal Articles
J Cell Sci (2007) 120 (20): 3678–3687.
Published: 15 October 2007
...-protein interaction Telomeres are the ends of linear eukaryotic chromosomes. Their main function is to maintain genome integrity by replicating chromosome ends and protecting them from exonucleolytic degradation and mutual fusions (reviewed in Blackburn, 2001 ). Telomeres also have a role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3337–3344.
Published: 1 October 2007
... and biochemical studies have revealed how β-catenin engages in critical protein-protein interactions by using its armadillo repeat region and its N- and C-terminal domains. The groove in the armadillo repeat region is a particularly interesting feature of β-catenin, since it serves as a common binding site...
Journal Articles
J Cell Sci (2007) 120 (13): 2171–2178.
Published: 1 July 2007
.... This effect is associated with specific intracellular protein-protein interaction and the formation of a sG i2 –D 2 -receptor complex. It has been suggested that the formation of this complex serves to prevent D 2 receptors from reaching the cell membrane. Treatment of D 2 -receptor-expressing cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (9): 1885–1897.
Published: 1 May 2005
... in protein-protein interaction (e.g. stabilizing the protein interaction). It is of note that overexpression of a deletion mutant of SCAMP1 lacking the N-terminal domain potently inhibited transferrin uptake by endocytosis ( Fernandez-Chacon et al., 2000 ). Longer isoforms and shorter isoforms of SCAMPs may...
Journal Articles
J Cell Sci (2002) 115 (7): 1411–1422.
Published: 1 April 2002
... the same modular organisation of mammalian Fe65s, including the WW, PTB1 and PTB2 domains, confirming that the three protein-protein interaction domains constitute the main functional regions of these molecular adaptors. The PTB2 domain of FEH-1 is also functionally related to the corresponding domains...