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Keywords: Protein-protein interaction
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Metabolism
J Cell Sci (2022) 135 (23): jcs260313.
Published: 5 December 2022
... roles are poorly characterized. Here, we identify a surprising new mechanism for its role in electrolyte homeostasis. mTOR mTORC2 Rictor SGK1 WNK1 WNK kinase ENaC Electrolytes Ion transport K + homeostasis Kidney epithelial cells Proteinprotein interaction National Institutes...
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Proteostasis
J Cell Sci (2020) 133 (11): jcs240283.
Published: 11 June 2020
...: The Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site. Cell polarity Proteinprotein interaction SPLIFF Positive feedback Split-ubiquitin Yeast Cdc42...
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Imaging
J Cell Sci (2018) 131 (1): jcs210419.
Published: 8 January 2018
... in a high-content analysis. GTPase activation Split-GFP Proteinprotein interaction GEF Guanine nucleotide exchange factor Cell-based assays High-content analysis La Ligue Régionale contre le Cancer Institut National de la Santé et de la Recherche Médicale Small...
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Proteostasis
J Cell Sci (2017) 130 (6): 1027–1036.
Published: 15 March 2017
... ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation. Epithelial Na + channel Derlin-1 Ubiquitylation Proteinprotein interaction Ubiquitin-mediated proteasome degradation National...
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Journal Articles
J Cell Sci (2016) 129 (21): 3983–3988.
Published: 1 November 2016
... luminal domain is the minimal requirement to form the sarcoplasmic reticulum Ca 2+ sensor, which governs cardiac Ca 2+ homeostasis and reliable heartbeat. Ca 2+ intracellular release Calsequestrin Excitation-contraction coupling Luminal Ca 2+ sensor Proteinprotein interaction Ryanodine...
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Journal Articles
J Cell Sci (2015) 128 (19): 3621–3630.
Published: 1 October 2015
..., and FoxO1 phosphorylation promotes ENaC membrane trafficking by binding to 14-3-3ε in epithelium. Epithelial Na + channel FoxO1 14-3-3ε Proteinprotein interaction Protein phosphorylation The epithelial Na + channel (ENaC) localizes to the apical membranes of principal cells...
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Journal Articles
J Cell Sci (2015) 128 (17): 3210–3222.
Published: 1 September 2015
...–LPPR1ΔC43 or EGFP. GFP–Trap beads were added to co-immunoprecipitate EGFP-tagged proteins and their binding partners. Because proteinprotein interactions can be either weak or strong, considering both the coverage of binding protein identification and the binding specificity, we performed two independent...
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Journal Articles
J Cell Sci (2015) 128 (12): 2302–2313.
Published: 15 June 2015
... induces Rap1 activation to promote its own surface expression by stimulating receptor recycling, thereby providing a potential explanation for the long-lasting action of GABA. GABA B receptor Rap1 Proteinprotein interaction Internalization Recycling For many GPCRs, signal transduction...
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Journal Articles
J Cell Sci (2015) 128 (12): 2351–2362.
Published: 15 June 2015
... and RFP fusion proteins for immunoprecipitation with anti-GFP nanobody, proteinprotein interactions could be reproducibly visualized by directly observing the immunoprecipitates under a microscope, and evaluated using a microplate reader, without requiring immunoblotting. Using this ‘visible...
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Journal Articles
J Cell Sci (2014) 127 (16): 3614–3624.
Published: 15 August 2014
... ( [email protected] ) Competing interests The authors declare no competing interests. 17 03 2014 8 05 2014 © 2014. Published by The Company of Biologists Ltd 2014 Cytokinesis IQGAP F-BAR protein Proteinprotein interaction In the budding yeast Saccharomyces...
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Journal Articles
J Cell Sci (2008) 121 (19): 3121–3132.
Published: 1 October 2008
... for the development of effective therapeutic agents. * Author for correspondence (e-mail: [email protected] ) 7 8 2008 © The Company of Biologists Limited 2008 2008 Cancer Development Extracellular matrix Integrin-linked kinase Protein-protein interaction Signal transduction...
Journal Articles
J Cell Sci (2007) 120 (20): 3678–3687.
Published: 15 October 2007
...-protein interaction Telomeres are the ends of linear eukaryotic chromosomes. Their main function is to maintain genome integrity by replicating chromosome ends and protecting them from exonucleolytic degradation and mutual fusions (reviewed in Blackburn, 2001 ). Telomeres also have a role...
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J Cell Sci (2007) 120 (19): 3337–3344.
Published: 1 October 2007
... and biochemical studies have revealed how β-catenin engages in critical protein-protein interactions by using its armadillo repeat region and its N- and C-terminal domains. The groove in the armadillo repeat region is a particularly interesting feature of β-catenin, since it serves as a common binding site...
Journal Articles
J Cell Sci (2007) 120 (13): 2171–2178.
Published: 1 July 2007
.... This effect is associated with specific intracellular protein-protein interaction and the formation of a sG i2 –D 2 -receptor complex. It has been suggested that the formation of this complex serves to prevent D 2 receptors from reaching the cell membrane. Treatment of D 2 -receptor-expressing cells...
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Journal Articles
J Cell Sci (2001) 114 (7): 1253–1263.
Published: 1 April 2001
...-protein interaction Modular binding domains Signal transduction The idea that specific protein-protein interactions govern many biological processes is by now so deeply ingrained that it is easy to forget that it has only been a decade or so since this was widely appreciated. In that time...
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