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Keywords: Protein trafficking
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Journal Articles
J Cell Sci (2022) 135 (13): jcs259806.
Published: 8 July 2022
... for the development of innovative therapeutic approaches. Plasma membrane protein Plasma membrane quality control Plasma membrane repair Protein trafficking Therapy European Regional Development Fund http://dx.doi.org/10.13039/501100008530 CENTRO-01-0145-FEDER-000012-N2323 UIDP/04539/2020...
Journal Articles
J Cell Sci (2021) 134 (18): jcs255927.
Published: 17 September 2021
... to the apical surface results in the formation of ectopic lumens in MDCK cysts in 3D cultures. 3D Matrigel culture Epidermal growth factor receptor EGFR Epiregulin EREG Epithelial polarity Epithelial transformation Protein trafficking National Institutes of Health http://dx.doi.org...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (20): jcs232058.
Published: 23 October 2019
... for defective NIS protein trafficking and localization in breast cancer cell. Sodium iodide symporter NIS SLC5A5 Protein trafficking Glycosylation Mannosidase Breast cancer In humans, sodium iodide symporter (NIS, officially known as SLC5A5) is the sole iodine pump protein present in certain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226134.
Published: 3 April 2019
... localization signal and a terminal transmembrane domain are sufficient to allow trafficking of proteins to the inner nuclear envelope in plants. Protein trafficking Tail-anchored protein Nuclear localization signal Plant Inner nuclear membrane National Science Foundation 10.13039/100000001...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs209346.
Published: 7 June 2018
... protein Membrane nanotube Plasmodesmata Protein trafficking Cell–cell channels Cell-to-cell movement Cytoplasmic bridges Callose Summary: This Cell Science at a Glance article summarizes how plasmodesmata are dynamic and multifaceted nanochannels that bridge neighboring plant cells. ©...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs202838.
Published: 29 January 2018
..., the underlying mechanism(s) for SNARE targeting in plants remains obscure. Here, we investigate the targeting mechanism of the Arabidopsis thaliana Qc-SNARE BET12, which is involved in protein trafficking in the early secretory pathway. Two distinct signal motifs that are required for efficient BET12 ER export...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2599–2612.
Published: 1 July 2016
... to stabilization of CFTR at the plasma membrane, through a mechanism that involves the PDZ adaptor NHERF1, and could be used to increase the rescue of mutant CFTR. CFTR cAMP EPAC1 Membrane stability Protein trafficking Fundação para a Ciência e a Tecnologia 10.13039/501100001871 UID/MULTI...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 843–853.
Published: 15 February 2016
... out of water by a reverse overshot water-wheel. Glyceraldehyde-3-phosphate dehydrogenase GAPDH Apotransferrin Moonlighting protein Iron Retroendocytosis Microscopy Protein trafficking A fundamental requirement for all life processes from the cellular to societal level...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4039–4045.
Published: 15 November 2015
... are continuously renewed, with aged membrane removed at the distal end by phagocytosis and new membrane added at the proximal end through OS disk morphogenesis linked to protein trafficking. The molecular basis for disk morphogenesis remains to be defined in detail although several models have been proposed...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
J Cell Sci (2015) 128 (22): 4220–4234.
Published: 15 November 2015
...-arrestins bind the Rho1 GTPase and regulate internalization of selective cargo through the clathrin-independent endocytic pathway. Plasma membrane Internalization Protein trafficking Ubiquitin ligase Yeast Organelle identity, membrane composition and cellular signaling rely on accurate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1934–1945.
Published: 15 May 2015
...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Cilia Protein Trafficking SUMO Cilia are evolutionarily conserved organelles projecting from the surface of cells and are important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4904–4917.
Published: 15 November 2014
...Zhe Wang; Chao Zhang; Robert Z. Qi ABSTRACT The Golgi of mammalian cells is known to be a major microtubule-organizing site that requires microtubules for its organization and protein trafficking. However, the mechanisms underlying the microtubule organization of the Golgi remain obscure. We used...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3675–3686.
Published: 1 September 2014
... mature peroxisomes to determine whether other PMPs also target to peroxisomes via the group I pathway. The ER trafficking pathway should be significantly slower than the direct import pathway owing to the inherent complexity of protein trafficking between two organelles ( Lodish, 1988 ; Zaal et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5412–5421.
Published: 1 December 2013
... Hippocampal culture Protein trafficking Frontotemporal dementia Progranulin (PGRN) is a multi-functional, secreted growth factor expressed in a variety of tissues throughout the body ( Bateman and Bennett, 2009 ). In the adult brain, PGRN is expressed in microglia, in pyramidal neurons of the cortex...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (21): 4985–4990.
Published: 1 November 2012
.... * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) 19 7 2012 © 2012. Published by The Company of Biologists Ltd 2012 Acrosome reaction Membrane fusion Protein trafficking Live-cell imaging IZUMO1 Sperm–egg fusion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2012) 125 (3): 763–776.
Published: 1 February 2012
... that assured expression of the constructs at the level of endogenous lgd . This was necessary because we found that the process of protein trafficking is very sensitive to overexpression of Lgd. Thus, data obtained by overexpression of Lgd proteins (e.g. in cell culture) must be interpreted with great caution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3381–3392.
Published: 15 October 2011
... context for their function. In this Commentary, we give a brief overview of the different mechanisms that are involved in protein trafficking and describe how aberrant localization of proteins contributes to the pathogenesis of many human diseases, such as metabolic, cardiovascular and neurodegenerative...