... of tail-anchored proteins pathway re-localize to dynamic cytosolic foci enriched in metabolic enzymes and chaperones, which are resolved by NADH. Chaperone Protein targeting Get3 ATPase Membraneless organelle Glucose metabolism Cellular stress Deutsche Forschungsgemeinschaft http...

... of Mitochondrial Proteins . Trends Biochem. Sci. 45 , 650 - 667 . 10.1016/j.tibs.2020.04.001 Casson , J. , McKenna , M. and High , S. ( 2016 ). On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control . Biochem. Soc. Trans. 44...

... into the ER is co-translational, mediated by the ER membrane protein complex and may involve topology reorientation. Co-translational Endoplasmic reticulum Lipid droplets Membrane proteins Protein targeting Wellcome Trust http://dx.doi.org/10.13039/100010269 204957/Z/16/Z...

... to monitor the relocalization of lipid droplet proteins. LD proteins of the two mating partners quickly re-equilibrate their localization resulting in a uniform LD population. Lipid droplets Endoplasmic reticulum Saccharomyces cerevisiae Protein targeting Mating Membrane fusion Seipin...

... with Mdh3 and a Pex5-dependent piggybacking mechanism. Peroxisomes Protein targeting Malate dehydrogenase Glyoxylate cycle Piggybacking Pex5 European Research Council 10.13039/100010663 64660 Deutsche Forschungsgemeinschaft 10.13039/501100001659 FOR1905 H2020...

... . 10.1016/j.celrep.2014.08.056 Bersuker , K. and Olzmann , J. A. ( 2017 ). Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation . Biochim. Biophys. Acta Mol. Cell Biol. Lipids   1862 , 1166 - 1177 . 10.1016/j.bbalip.2017.06.006...

... protein targeting to lipid droplets . Dev. Cell.   44 , 73 - 86 e74 . 10.1016/j.devcel.2017.12.011 Pu , J. , Ha , C. W. , Zhang , S. , Jung , J. P. , Huh , W.-K. and Liu , P. ( 2011 ). Interactomic study on interaction between lipid droplets and mitochondria...

... an overview of our current understanding of the multifaceted and regulated processes of protein targeting and translocation to the ER. * Present address: Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA. ¶ Author for correspondence ( [email protected] ) ©...

... grown in oleate and highlighted a new condition-specific peroxisomal protein, Pex9, which targets a subset of proteins to peroxisomes. Peroxisome Protein targeting Glucose Oleate Saccharomyces cerevisiae High-content screen European Research Council 10.13039/501100000781 64660...

..., however, plastids were acquired by secondarily engulfing green or red algae, which were retained within the endomembrane system. Protein targeting to these secondary plastids is more complex, and because they do not reside directly in the cytoplasm, dual targeting cannot function as it does in plant cells...

... microsystems, Bensheim, Germany). * Author for correspondence (e-mail: [email protected] ) 16 2 2006 © The Company of Biologists Limited 2006 2006 Adaptin Clathrin-mediated endocytosis Protein targeting For most mammalian cells, glucose is the primary source...

... hepatic cells. Apart from these relatively well-recognized sorting mechanisms, the role played by protein glycosylation, especially N-glycans, in regulating protein targeting remain somewhat controversial. In addition to the generally accepted role of protein glycosylation in modulating protein...

... during degradation. (e-mail: [email protected] ) © The Company of Biologists Limited 2005 2005 Lysosome Pexophagy Protein targeting Vacuole Yeast Autophagy is a ubiquitous process, occurring in all eukaryotic cells ( Klionsky, 2004 ; Reggiori and Klionsky, 2002...

...-mail: [email protected] ) 1 12 2003 © The Company of Biologists Limited 2004 2004 Unconventional protein secretion Nonclassical export Fibroblast growth factor FGF-2 Membrane translocation Protein targeting Many examples of protein translocation across membranes...

... of eNOS by Akt also increases activity. (e-mail: [email protected] ) © The Company of Biologists Limited 2003 2003 Nitric oxide Heart Protein targeting PDZ domain The free radical gas nitric oxide (NO) is now recognized as a major messenger molecule that has diverse functions...

... ) 27 9 2002 © The Company of Biologists Limited 2002 2002 Casein kinase 1 GFP fusion proteins Protein targeting AKR1 Casein kinase I (CK1) protein kinases comprise a large subfamily of acidic serine/threonine-specific protein kinases that is strongly conserved from yeast...

... and outer membrane. ‡ Author for correspondence (e-mail: [email protected] ) 24 1 2002 © The Company of Biologists Limited 2002 2002 Transmembrane protein Protein targeting GTPase Mitochondria Membrane fusion Mitochondria represent a tubular and branched...

... Limited 2002 2002 PP1 Protein targeting Insulin action Smooth muscle contraction Pre-mRNA splicing AKAP Neurabin 53BP2 The human genome encodes ∼500 protein kinases, approximately two thirds of which are serine/threonine kinases. The four distinct families of protein phosphatases...

...-lmb.cam.ac.uk ) 24 10 2001 © The Company of Biologists Limited 2002 2002 Emerin Lamin A/C Cell cycle Protein targeting Emery-Dreifuss muscular dystrophy Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) arise from genetic defects in the cytoplasmic/plasma...

...-mail: [email protected] ) 2 3 2001 © The Company of Biologists Limited 2001 2001 Membrane biogenesis Protein targeting Vesicular transport Peroxisome biogenesis Coatomer Eukaryotic cells contain numerous subcellular organelles whose specialized functions require distinct protein...