..., composition, dynamics, function and involvement in disease of SGs and PBs. * Authors for correspondence ( [email protected] ; [email protected] ) © 2020. Published by The Company of Biologists Ltd 2020 Cell stress Stress Granules P bodies Protein synthesis RNA metabolism...

... membrane. We generated three mutant knockout cell lines for the CL biosynthesis gene Crls1 to investigate the effects of CL loss on mitochondrial protein synthesis. Reduced CL levels caused altered mitochondrial morphology and transcriptome-wide changes that were accompanied by uncoordinated mitochondrial...

.... Puromycin Translation elongation factor B cell T cell Fetal liver Protein synthesis L'Association de la Recherche contre le Cancer 10.13039/501100004097 ARC PJA 20131200330 ARC PJA 20161204696 Fondation pour la Recherche Medicale 10.13039/501100002915 DEQ20140329536...

... protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although the first evidence for protein synthesis in axons dates back to 1960s, improved methodologies, including the ability to isolate axons to purity, highly sensitive RNA detection methods and imaging...

... and the signaling cascades required for local BDNF translation in dendrites in response to excitatory inputs. Neurotrophins Hippocampus Protein synthesis Pilocarpine Ministero dell'Istruzione, dell'Università e della Ricerca 10.13039/501100003407 PRIN2010-11 2010N8PBAA Fra-UniTs-2013...

...Jirapas Jongjitwimol; Robert A. Baldock; Simon J. Morley; Felicity Z. Watts ABSTRACT Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many...

... C. elegans Translation state array analysis TSAA Protein synthesis Meiotic maturation Cell fate, proliferation and differentiation are dependent on gene expression, often at the level of protein synthesis ( Kimble and Crittenden, 200 7). Dysregulation of these processes is associated...

... between autophagy and cell growth will also be discussed. [email protected] © 2012. 2012 Autophagy Cell growth Mammalian target of rapamycin (mTOR) Protein synthesis Lysosome Cell cycle Cells have an intrinsic drive to increase their mass, which is illustrated by the ravenous...

... used to produce KCP2-specific antibodies. The products of translational initiation at Met26 or Met27 are indistinguishable by SDS-PAGE, and therefore the precise AUG codon at which protein synthesis is normally initiated could not be determined by immunoblotting of the products. Examination...

... The Company of Biologists Limited 2009 2009 Cell growth IQGAP1 Protein synthesis Cell proliferation, which is generally controlled by the rate of protein synthesis, requires tight coordination of cell growth and division and a diverse number of proteins have been shown to affect both cell...

... and differentiation. Qualitative and quantitative changes in protein synthesis occur by translational control of mRNAs, mediated in part by eIF4E, which binds the mRNAs 5′ cap. IFE-1 is one of five eIF4E isoforms identified in C. elegans . IFE-1 is expressed primarily in the germ line and associates with P granules...

... spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms. J. Biol. Chem. 277 , 12559 -12571. Brandhorst, B. P. ( 1976 ). Two-dimensional gel patterns of protein synthesis before and after fertilization of sea urchin eggs. Dev. Biol. 52 , 310 -317...

...Sang Won Lee; Byeong Hoon Cho; Sang Gyu Park; Sunghoon Kim Although aminoacyl-tRNA synthetases (ARSs) are housekeeping enzymes essential for protein synthesis, they can play non-catalytic roles in diverse biological processes. Some ARSs are capable of forming complexes with each other...

...Sun-Kyung Lee; Peter J. Hollenbeck Many axons carry out the synthesis of macromolecules independent of their cell bodies but the nature, organization and magnitude of axonal protein synthesis remain unclear. We have examined these features in axons of chick sympathetic neurons in cell culture...

... Ubiquitin Protein synthesis The world teems with viruses awaiting the opportunity to tap the inviting resources of unsuspecting host organisms ( Flint et al., 2000 ). So much so, that in every host strategies for minimizing the effects of viruses on its reproductive potential have evolved...

... 13 08 1996 © 1996 by Company of Biologists 1996 EGF Protein synthesis Cytoskeleton Chemotaxis Cell motility Fig. 1. (A) Immunodetection of EF1α in (a,b) a total homogenate from rat tumors derived from injected MTLn3 cells; and in (c,d) a total homogenate from normal rat...

....medfac.leidenuniv.nl) 03 01 1995 14 02 1996 © 1996 by Company of Biologists 1996 Localization Protein synthesis EF-1 Antibody The main role of elongation factor-1 (EF-1) in the process of protein biosynthesis lies in the binding and transportation of aminoacyltRNAs to the ribosome...

... phosphoglycerate kinase protein synthesis Circadian rhythms have been demonstrated in a wide range of behavioral, physiological and biochemical parameters in different organisms from single cells to man ( Aschoff, 1989 ; Bünning, 1973 ; Edmunds, 1988 ; Lorenzen et al., 1985 ; Schweiger et al., 1964...

...-A membrane turnover regeneration protein synthesis protein transport sea urchin embryo Ciliogenesis in the sea urchin blastula takes place prior to hatching by the coordinated, de novo synthesis of a number of 9+2 structural proteins. The resynthesis of most of these same proteins recurs after...

... circahoralian oscillations of the ATP level and similar oscillations of the leucine tRNA aminoacylation rate in a hepatocyte monolayer. The addition of 1 mM ADP to the culture resulted in a considerable increase in the ATP level in the cells, but the rhythm of protein synthesis was retained under...