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Keywords: Protein synthesis
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Journal Articles
J Cell Sci (2020) 133 (16): jcs242487.
Published: 01 September 2020
..., composition, dynamics, function and involvement in disease of SGs and PBs. * Authors for correspondence ( pivanov@rics.bwh.harvard.edu ; panderson@bwh.harvard.edu ) © 2020. Published by The Company of Biologists Ltd 2020 Cell stress Stress Granules P bodies Protein synthesis RNA metabolism...
Includes: Supplementary data
Journal Articles
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Mitochondria
J Cell Sci (2020) 133 (14): jcs240374.
Published: 24 July 2020
... membrane. We generated three mutant knockout cell lines for the CL biosynthesis gene Crls1 to investigate the effects of CL loss on mitochondrial protein synthesis. Reduced CL levels caused altered mitochondrial morphology and transcriptome-wide changes that were accompanied by uncoordinated mitochondrial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs214346.
Published: 31 May 2018
.... Puromycin Translation elongation factor B cell T cell Fetal liver Protein synthesis Protein synthesis is a central metabolic process that is regulated at different biochemical levels. Polypeptide elongation by ribosomes proceeds discontinuously, with pauses regulating the speed of protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs196808.
Published: 13 April 2018
... protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although the first evidence for protein synthesis in axons dates back to 1960s, improved methodologies, including the ability to isolate axons to purity, highly sensitive RNA detection methods and imaging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (14): 2852–2864.
Published: 15 July 2016
... and the signaling cascades required for local BDNF translation in dendrites in response to excitatory inputs. Neurotrophins Hippocampus Protein synthesis Pilocarpine Translation of a subset of dendritically localized mRNAs in close proximity to activated synapses is a fundamental mechanism...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2407–2415.
Published: 15 June 2016
...Jirapas Jongjitwimol; Robert A. Baldock; Simon J. Morley; Felicity Z. Watts ABSTRACT Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4487–4498.
Published: 15 December 2015
... C. elegans Translation state array analysis TSAA Protein synthesis Meiotic maturation Cell fate, proliferation and differentiation are dependent on gene expression, often at the level of protein synthesis ( Kimble and Crittenden, 200 7). Dysregulation of these processes is associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2359–2368.
Published: 15 May 2012
... between autophagy and cell growth will also be discussed. neufeld@med.umn.edu © 2012. 2012 Autophagy Cell growth Mammalian target of rapamycin (mTOR) Protein synthesis Lysosome Cell cycle Cells have an intrinsic drive to increase their mass, which is illustrated by the ravenous...
Journal Articles
J Cell Sci (2012) 125 (1): 220–232.
Published: 01 January 2012
... Endoplasmic reticulum KKxx motif N-glycosylation Protein synthesis Transmembrane topology We have characterised KCP2 with respect to its membrane topology, subcellular localisation and physical associations. We identified native human KCP2 to be the product of alternative translation initiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2024–2033.
Published: 15 June 2009
... that IQGAP1 binds the exocyst-septin complex and the ER-translocon subunit Sec61β through its N-terminus and promotes protein synthesis and secretion. CDC42, which binds the C-terminal region of IQGAP1, disrupts this interaction and inhibits IQGAP1-mediated secretion ( Rittmeyer et al., 2008 ). However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1529–1539.
Published: 15 May 2009
... and differentiation. Qualitative and quantitative changes in protein synthesis occur by translational control of mRNAs, mediated in part by eIF4E, which binds the mRNAs 5′ cap. IFE-1 is one of five eIF4E isoforms identified in C. elegans . IFE-1 is expressed primarily in the germ line and associates with P granules...
Journal Articles
J Cell Sci (2007) 120 (3): 425–434.
Published: 01 February 2007
... ‡ Present address: UMR6061, CNRS, Campus Villejean, avenue du professeur Léon Bernard, 35043 Rennes CEDEX, France 14 11 2006 © The Company of Biologists Limited 2007 2007 Sea urchin fertilization eIF4E eIF4G 4E-BP Protein synthesis Cell cycle Embryonic early development...
Journal Articles
J Cell Sci (2004) 117 (17): 3725–3734.
Published: 01 August 2004
...Sang Won Lee; Byeong Hoon Cho; Sang Gyu Park; Sunghoon Kim Although aminoacyl-tRNA synthetases (ARSs) are housekeeping enzymes essential for protein synthesis, they can play non-catalytic roles in diverse biological processes. Some ARSs are capable of forming complexes with each other...
Journal Articles
J Cell Sci (2003) 116 (21): 4467–4478.
Published: 01 November 2003
...Sun-Kyung Lee; Peter J. Hollenbeck Many axons carry out the synthesis of macromolecules independent of their cell bodies but the nature, organization and magnitude of axonal protein synthesis remain unclear. We have examined these features in axons of chick sympathetic neurons in cell culture...
Journal Articles
J Cell Sci (1989) 94 (2): 259–265.
Published: 01 October 1989
...D.E. LA TORRE; A. GONZALEZ-FERNADEZ; G. GIMENEZ-MARTIN Different responses were detected when inhibiting protein synthesis (by 1μgml −1 anisomycin) for similar times (3 h) in each of the four regions of the plant cell cycle where synthesis of specific proteins seems to control further cycle...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 77–97.
Published: 01 February 1989
...). Cell division has been studied from a wide range of different perspectives, depending on the particular interests of the investigators and what techniques were available to them. Our own entry into this field arose naturally but by chance from studies of protein synthesis in the oocytes and eggs...
Journal Articles
J Cell Sci (1988) 91 (4): 531–539.
Published: 01 December 1988
... to, but with a constant delay behind, the corresponding RNA steps. When protein synthesis is suppressed (e.g. by maintaining the cells in the dark) after an RNA synthesis step has already occurred the cells double their DNA content, but no corresponding nuclear division occurs and uninuclear daughter cells with double...