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Keywords: Protein misfolding
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Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 04 June 2021
...: Identification of cellular systems that impinge on protein homeostasis during arsenite stress in yeast, showing that transcriptional and translational control is central for mitigating protein aggregation and toxicity. Arsenic Protein misfolding Protein aggregation Transcription Translation Protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (9): jcs231662.
Published: 07 May 2019
... the recognition of cellular location signals embedded into the P2 residues of most proteins. N-end rule pathway Ubr1 Ubiquitin-mediated degradation Proteolysis Protein quality control Protein misfolding CytoQC N-degron Protein quality control (PQC) is an essential protein quality surveillance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (23): 4366–4378.
Published: 01 December 2016
... nuclear transport impairment. BRCA1 Cellular localization Missense mutation Protein misfolding Yeast model Breast and ovarian cancers are a major health concern, with respectively 1.67 and 0.24 million new cases diagnosed worldwide in 2012 ( http://globocan.iarc.fr/ ). Around 10...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3678–3685.
Published: 15 August 2013
... as described above. * Author for correspondence ( chiara.zurzolo@pasteur.fr ) 28 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 Protein misfolding HTT Intercellular transfer Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3942–3953.
Published: 01 November 2009
...-Merzbacher disease Protein misfolding Unfolded protein response A number of clinically important human diseases are known to be caused by protein misfolding at the endoplasmic reticulum (ER). The ER is a major site for the synthesis of membrane and secretory proteins in eukaryotic cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3737–3746.
Published: 15 November 2008
... Dominant-negative mutation Cataract formation Protein misfolding Chaperones Proteasomes Transgenic mice Mouse model systems Vimentin is a type-III intermediate filament (IF) protein that has been highly conserved during vertebrate evolution. It displays a typical tripartite domain structure...
Includes: Supplementary data