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1-20 of 53
Keywords: Protein kinase C
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Journal Articles
ORP3 phosphorylation regulates phosphatidylinositol 4-phosphate and Ca 2+ dynamics at plasma membrane–ER contact sites
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (6): jcs237388.
Published: 16 March 2020
... to transfer cholesterol and phosphatidylserine between the endoplasmic reticulum (ER) and other organelle membranes. Here, we show that plasma membrane (PM) association of ORP3 (also known as OSBPL3), a poorly characterized ORP family member, is triggered by protein kinase C (PKC) activation, especially when...
Includes: Supplementary data
Journal Articles
Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane
Available to PurchaseYosuke Senju, Eva Rosenbaum, Claudio Shah, Sayaka Hamada-Nakahara, Yuzuru Itoh, Kimiko Yamamoto, Kyoko Hanawa-Suetsugu, Oliver Daumke, Shiro Suetsugu
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (15): 2766–2780.
Published: 1 August 2015
...Yosuke Senju; Eva Rosenbaum; Claudio Shah; Sayaka Hamada-Nakahara; Yuzuru Itoh; Kimiko Yamamoto; Kyoko Hanawa-Suetsugu; Oliver Daumke; Shiro Suetsugu ABSTRACT PACSIN2, a membrane-sculpting BAR domain protein, localizes to caveolae. Here, we found that protein kinase C (PKC) phosphorylates PACSIN2...
Includes: Supplementary data
Journal Articles
Transient PKCα shuttling to the immunological synapse is governed by DGKζ and regulates L-selectin shedding
Available to PurchaseSeverine I. Gharbi, Antonia Avila-Flores, Denise Soutar, Ana Orive, Gary A. Koretzky, Juan Pablo Albar, Isabel Mérida
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (10): 2176–2186.
Published: 15 May 2013
... dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life 60 , 782 – 789 . 10.1002/iub.122 Gharbi S. I. , Rincón E. , Avila-Flores A. , Torres-Ayuso P. , Almena M. , Cobos M. A. , Albar J. P. , Mérida I. ( 2011 ). Diacylglycerol kinase ζ...
Includes: Supplementary data
Journal Articles
VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells
Available to PurchaseMohamed M. Bekhite, Andreas Finkensieper, Stephanie Binas, Jörg Müller, Reinhard Wetzker, Hans-Reiner Figulla, Heinrich Sauer, Maria Wartenberg
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (11): 1819–1830.
Published: 1 June 2011
...Mohamed M. Bekhite; Andreas Finkensieper; Stephanie Binas; Jörg Müller; Reinhard Wetzker; Hans-Reiner Figulla; Heinrich Sauer; Maria Wartenberg VEGF-, phosphoinositide 3-kinase (PI3K)- and protein kinase C (PKC)-regulated signaling in cardiac and vascular differentiation was investigated in mouse...
Includes: Supplementary data
Journal Articles
Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (9): 1542–1552.
Published: 1 May 2011
... near this polybasic region, potentially by protein kinase C, releases SH2B1β from the PM and enhances nuclear entry. Release of SH2B1β from the PM and/or nuclear entry appear to be required for SH2B1β enhancement of nerve growth factor (NGF)-induced expression of urokinase plasminogen activator...
Includes: Supplementary data
Journal Articles
Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (24): 4310–4320.
Published: 15 December 2010
... ERK regulation in single intact cells, we find that, when protein kinase C or epidermal growth factor receptors are activated, a substantial fraction of the ERK nuclear localization response is uncoupled from TEY phosphorylation. This phosphorylation-unattributable nuclear localization response occurs...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (24): 4452–4464.
Published: 15 December 2009
... element (ARE) and activates defensive gene expression, which protects cells. Controversies exist regarding the role of antioxidant-induced modification of INrf2 cysteine 151 or protein kinase C (PKC)-mediated phosphorylation of Nrf2 serine 40 in the release of Nrf2 from INrf2. In addition, the PKC isoform...
Includes: Supplementary data
Journal Articles
The PKCδ -Abl complex communicates ER stress to the mitochondria – an essential step in subsequent apoptosis
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (6): 804–813.
Published: 15 March 2008
... 2008 Protein kinase C Apoptosis Abl Endoplasmic reticulum Mitochondria Endoplasmic reticulum (ER) functions can be impaired by various intracellular and extracellular stimuli that lead to ER stress. Cells respond to ER stress by activating a signaling cascade termed the unfolded...
Includes: Supplementary data
Journal Articles
Protein-kinase-C-mediated β-catenin phosphorylation negatively regulates the Wnt/β-catenin pathway
Available to PurchaseJungsug Gwak, Munju Cho, Soo-Jung Gong, Jaejoon Won, Dong-Eun Kim, Eun-Young Kim, Sang Sup Lee, Mina Kim, Tae Kook Kim, Jae-Gook Shin, Sangtaek Oh
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (22): 4702–4709.
Published: 15 November 2006
... the development of cancer. The key mechanism in regulation of the Wnt/β-catenin pathway is the amino-terminal phosphorylation of β-catenin, marking it for proteasomal degradation. Here we present small-molecule-based identification of protein kinase C (PKC)-mediated β-catenin phosphorylation as a novel mechanism...
Includes: Supplementary data
Journal Articles
Host cell Ca 2+ and protein kinase C regulate innate recognition of Toxoplasma gondii
Available to PurchaseKatherine S. Masek, Jim Fiore, Michael Leitges, Shi-Fang Yan, Bruce D. Freedman, Christopher A. Hunter
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (21): 4565–4573.
Published: 1 November 2006
... The Company of Biologists Limited 2006 2006 Toxoplasma gondii Interleukin 12 Mitogen-activated protein kinase Ca 2+ Macrophage/monocyte Protein kinase C Toxoplasma gondii is a protozoan pathogen that chronically infects a significant percentage of the world's population. In healthy...
Journal Articles
Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (24): 5743–5754.
Published: 15 December 2005
... is accompanied by relocalisation of protein kinase C α to desmosomal plaques suggesting that an `inside-out' transmembrane signal is responsible for changing desmosomal adhesiveness. We model hyper-adhesive desmosomes using the crystal packing observed for the ectodomain of C-cadherin and show how the regularity...
Journal Articles
Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (17): 3849–3859.
Published: 1 September 2005
.../cyclosome. The signal transduction pathway is not fully resolved but both protein kinase C (PKC) and calmodulin-dependent protein kinase II (CamKII) activities increase at fertilization and previous pharmacological studies have implicated both in cell-cycle resumption. We have used a combination...
Journal Articles
Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (8): 1641–1649.
Published: 15 April 2005
... , 1649 -1658. Becker, K. P. and Hannun, Y. A. ( 2003 ). cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J. Biol. Chem. 278 , 52747 -52754. Becker, K. P. and Hannun, Y. A. ( 2004 ). Isoenzyme-specific translocation of protein kinase C (PKC...
Journal Articles
Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes
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Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (10): 1971–1978.
Published: 15 April 2004
...Xupei Huang; Jeffery W. Walker Regulatory proteins on muscle filaments are substrates for protein kinase C (PKC) but mechanisms underlying activation and translocation of PKC to this non-membrane compartment are poorly understood. Here we demonstrate that the epsilon isoform of PKC (ϵ-PKC...
Journal Articles
Targeting of PKCα and ϵ in the pituitary: a highly regulated mechanism involving a GD(E)E motif of the V3 region
Available to PurchaseCorinne Quittau-Prévostel, Nathalie Delaunay, Alejandra Collazos, Alice Vallentin, Dominique Joubert
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (1): 63–72.
Published: 1 January 2004
...Corinne Quittau-Prévostel; Nathalie Delaunay; Alejandra Collazos; Alice Vallentin; Dominique Joubert Protein kinase C (PKC) has been implicated in the control of intercellular adhesion. Our previous observation demonstrating that activated PKC alpha (PKCα is selectively targeted to cell-cell...
Journal Articles
Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells
Available to PurchaseElke Vermassen, Kristel Van Acker, Wim G. Annaert, Bernard Himpens, Geert Callewaert, Ludwig Missiaen, Humbert De Smedt, Jan B. Parys
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (7): 1269–1277.
Published: 1 April 2003
... could be blocked by the simultaneous addition of nocodazole or taxol and depended on Ca 2+ release from intracellular stores since Ca 2+ -mobilizing agents such as thapsigargin and cyclopiazonic acid could induce the redistribution. Furthermore, various protein kinase C inhibitors could inhibit...
Journal Articles
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (24): 4777–4786.
Published: 15 December 2002
... of protein kinase C, but not that of actin polymerization, inhibited the PINCH-ILK-CH-ILKBP complex formation, suggesting that the PINCH-ILK-CH-ILKBP complex likely serves as a downstream effector of protein kinase C in the cellular control of focal adhesion assembly. Finally,we provide evidence...
Journal Articles
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters
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Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (23): 4399–4411.
Published: 1 December 2002
...Nils Brose; Christian Rosenmund Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family. However,at least five alternative types...
Journal Articles
Suppression of Synaptotagmin II restrains phorbolester-induced downregulation of protein kinase Cα by diverting the kinase from a degradative pathway to the recycling endocytic compartment
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (15): 3083–3092.
Published: 1 August 2002
... 2002 Protein kinase C Synaptotagmin TPA Mast cells Endosome Protein kinase C (PKC) is a family of Ser/Thr kinases that plays a pivotal role in mediating cellular response cascades, including ones for growth and differentiation ( Mellor and Parker,1998 ). PKC isoforms include the Ca 2...
Journal Articles
Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells
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Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (13): 2713–2724.
Published: 1 July 2002
... and microvilli of A431 cells after treatment with EGF. However, A431 cells expressing dominant-negative c-Jun (TAM67), and which as a consequence fail to invade in response to EGF, also fail to correctly localise CD44 and ezrin. CD44 and ezrin are both substrates for Protein Kinase C, and we show that their EGF...
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